STRINGSTRING
BMPR1B BMPR1B PDCD4 PDCD4 SMAD9 SMAD9 TMEM100 TMEM100 MAPK3 MAPK3 DDX5 DDX5 FST FST DLX5 DLX5 USP9X USP9X BMP4 BMP4 ZNF831 ZNF831 HJV HJV RGMA RGMA CCDC142 CCDC142 TGFBR3L TGFBR3L SMAD7 SMAD7 ENSUAMP00000026773 ENSUAMP00000026773 ENSUAMP00000026772 ENSUAMP00000026772 SMAD2 SMAD2 SMAD6 SMAD6 SMAD3 SMAD3 ZNF8 ZNF8 TMPRSS6 TMPRSS6 ENSUAMP00000024123 ENSUAMP00000024123 SOST SOST TGFBR3 TGFBR3 ENSUAMP00000010701 ENSUAMP00000010701 ENSUAMP00000012044 ENSUAMP00000012044 ENSUAMP00000012266 ENSUAMP00000012266 EXT1 EXT1 MEGF8 MEGF8 ENSUAMP00000014216 ENSUAMP00000014216 CHRDL1 CHRDL1 GDF3 GDF3 FAM83G FAM83G ACVR2A ACVR2A BMP10 BMP10 USP15 USP15 TGFB3 TGFB3 ENSUAMP00000016813 ENSUAMP00000016813 SOSTDC1 SOSTDC1 ACVRL1 ACVRL1 ENSUAMP00000017561 ENSUAMP00000017561 DLX3 DLX3 SMAD4 SMAD4 SLC33A1 SLC33A1 SMPD3 SMPD3 HFE HFE BMP2 BMP2 SMAD5 SMAD5 ENSUAMP00000023083 ENSUAMP00000023083 HES1 HES1 ENSUAMP00000008401 ENSUAMP00000008401 ACVR2B ACVR2B TWSG1 TWSG1 CHRD CHRD SFRP1 SFRP1 ENSUAMP00000004097 ENSUAMP00000004097 ACVR1 ACVR1 ENSUAMP00000003640 ENSUAMP00000003640 ENSUAMP00000003258 ENSUAMP00000003258 DSG4 DSG4 SPART SPART NOG NOG ENSUAMP00000000756 ENSUAMP00000000756 MSX1 MSX1 EGR1 EGR1 GDF6 GDF6 GDF2 GDF2 ATF2 ATF2 NODAL NODAL ABL1 ABL1 GDF5 GDF5 ENSUAMP00000037566 ENSUAMP00000037566 BMPR2 BMPR2 COMP COMP BMPR1A BMPR1A SLC39A5 SLC39A5 RGMB RGMB ENSUAMP00000035777 ENSUAMP00000035777 ENSUAMP00000034195 ENSUAMP00000034195 ENSUAMP00000033951 ENSUAMP00000033951 NOTCH2 NOTCH2 ENSUAMP00000033758 ENSUAMP00000033758
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
PDCD4Programmed cell death 4. (474 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
TMEM100Transmembrane protein 100. (134 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
FSTFollistatin. (344 aa)
DLX5Distal-less homeobox 5. (289 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2153 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ZNF831Zinc finger protein 831. (1654 aa)
HJVHemojuvelin BMP co-receptor. (317 aa)
RGMARepulsive guidance molecule BMP co-receptor a. (439 aa)
CCDC142Coiled-coil domain containing 142. (747 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (290 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ENSUAMP00000026773Uncharacterized protein. (179 aa)
ENSUAMP00000026772ETS domain-containing protein. (163 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
SMAD6Mothers against decapentaplegic homolog. (484 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
ZNF8Zinc finger protein 8. (566 aa)
TMPRSS6Transmembrane serine protease 6; Belongs to the peptidase S1 family. (800 aa)
ENSUAMP00000024123Uncharacterized protein. (522 aa)
SOSTSclerostin. (213 aa)
TGFBR3Transforming growth factor beta receptor 3. (808 aa)
ENSUAMP00000010701Uncharacterized protein. (51 aa)
ENSUAMP00000012044TGF_BETA_2 domain-containing protein. (154 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
MEGF8Multiple EGF like domains 8. (2820 aa)
ENSUAMP00000014216Homeobox domain-containing protein. (315 aa)
CHRDL1Chordin like 1. (414 aa)
GDF3Growth differentiation factor 3. (365 aa)
FAM83GFamily with sequence similarity 83 member G. (822 aa)
ACVR2ASerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (510 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
USP15Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (968 aa)
TGFB3Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
ENSUAMP00000016813Uncharacterized protein. (404 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
ENSUAMP00000017561Uncharacterized protein. (285 aa)
DLX3Distal-less homeobox 3. (287 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SLC33A1Solute carrier family 33 member 1. (550 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (355 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ENSUAMP00000023083Uncharacterized protein. (485 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
ENSUAMP00000008401TGF_BETA_2 domain-containing protein. (367 aa)
ACVR2BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (527 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
CHRDChordin; Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes. (949 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
ENSUAMP00000004097Uncharacterized protein. (245 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ENSUAMP00000003640Uncharacterized protein. (101 aa)
ENSUAMP00000003258Uncharacterized protein. (246 aa)
DSG4Desmoglein 4; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. (1039 aa)
SPARTSpartin. (672 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
MSX1Msh homeobox 1. (303 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
GDF6Growth differentiation factor 6. (289 aa)
GDF2Growth differentiation factor 2. (429 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
NODALNodal growth differentiation factor. (348 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
GDF5Growth differentiation factor 5. (499 aa)
ENSUAMP00000037566TGF_BETA_2 domain-containing protein. (293 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SLC39A5Solute carrier family 39 member 5. (472 aa)
RGMBRepulsive guidance molecule BMP co-receptor b. (441 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
ENSUAMP00000034195Uncharacterized protein. (1577 aa)
ENSUAMP00000033951Uncharacterized protein. (383 aa)
NOTCH2Notch receptor 2. (2374 aa)
ENSUAMP00000033758Uncharacterized protein. (409 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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