STRINGSTRING
GDF2 GDF2 MSX1 MSX1 PELO PELO ENSUAMP00000003258 ENSUAMP00000003258 ENSUAMP00000004456 ENSUAMP00000004456 TWSG1 TWSG1 CDH5 CDH5 HES1 HES1 GDF5 GDF5 FBXL15 FBXL15 KIAA1324L KIAA1324L ACVRL1 ACVRL1 SCUBE3 SCUBE3 SMAD4 SMAD4 GPC3 GPC3 RNF165 RNF165 CRB2 CRB2 CCN1 CCN1 KDR KDR TBX20 TBX20 NEO1 NEO1 KCP KCP SULF1 SULF1 BMP4 BMP4 UBE2O UBE2O ENG ENG ZNF423 ZNF423 ILK ILK NOTCH2 NOTCH2 NOTCH1 NOTCH1 ENSUAMP00000036061 ENSUAMP00000036061 ENSUAMP00000036078 ENSUAMP00000036078 BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GDF2Growth differentiation factor 2. (429 aa)
MSX1Msh homeobox 1. (303 aa)
PELOProtein pelota homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (385 aa)
ENSUAMP00000003258Uncharacterized protein. (246 aa)
ENSUAMP00000004456Ig-like domain-containing protein. (155 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (202 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
GDF5Growth differentiation factor 5. (499 aa)
FBXL15F-box and leucine rich repeat protein 15. (300 aa)
KIAA1324LKIAA1324 like. (1015 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
SCUBE3Signal peptide, CUB domain and EGF like domain containing 3. (977 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
RNF165Ring finger protein 165. (347 aa)
CRB2Crumbs cell polarity complex component 2. (1280 aa)
CCN1Cellular communication network factor 1. (382 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
TBX20T-box transcription factor 20. (448 aa)
NEO1Neogenin 1. (1000 aa)
KCPKielin cysteine rich BMP regulator. (1568 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (940 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
UBE2OUbiquitin conjugating enzyme E2 O. (1285 aa)
ENGEndoglin. (650 aa)
ZNF423Zinc finger protein 423. (1350 aa)
ILKIntegrin linked kinase. (503 aa)
NOTCH2Notch receptor 2. (2374 aa)
NOTCH1Notch receptor 1. (2547 aa)
ENSUAMP00000036061Uncharacterized protein. (1711 aa)
ENSUAMP00000036078Uncharacterized protein. (258 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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