35 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	AR	Androgen receptor. (905 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1044 aa)
	PHB2	Prohibitin. (297 aa)
	DAXX	Death domain associated protein. (756 aa)
	GPER1	G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	ARID1A	AT-rich interaction domain 1A. (1930 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	ENSUAMP00000032289	SAP domain-containing protein. (117 aa)
	ENSUAMP00000032266	RRM domain-containing protein. (778 aa)
	PHB	Prohibitin. (272 aa)
	PADI2	Peptidyl arginine deiminase 2. (673 aa)
	CST11	Cystatin 11. (137 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	SRC	Tyrosine-protein kinase. (557 aa)
	TRIP4	Thyroid hormone receptor interactor 4. (348 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (781 aa)
	POU4F2	POU domain protein. (408 aa)
	ENSUAMP00000025477	Uncharacterized protein. (185 aa)
	KDM3A	Lysine demethylase 3A. (1323 aa)
	YWHAH	Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
	TMF1	TATA element modulatory factor 1. (1089 aa)
	ENSUAMP00000023035	Uncharacterized protein. (527 aa)
	ENSUAMP00000020805	UBR-type domain-containing protein. (2331 aa)
	ENSUAMP00000016402	Uncharacterized protein. (427 aa)
	RBFOX2	RNA binding protein fox-1 homolog 2; RNA-binding protein that regulates alternative splicing events. (384 aa)
	ENSUAMP00000012231	Uncharacterized protein. (632 aa)
	CALCOCO1	Calcium binding and coiled-coil domain 1. (691 aa)
	ENSUAMP00000009766	Uncharacterized protein. (462 aa)
	ENSUAMP00000009436	HECT domain-containing protein. (51 aa)
	DDX17	DEAD-box helicase 17; Belongs to the DEAD box helicase family. (715 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	ENSUAMP00000004918	Homeobox domain-containing protein. (230 aa)
	ENSUAMP00000002304	Uncharacterized protein. (93 aa)
	PGR	Progesterone receptor. (634 aa)
	ENSUAMP00000000385	Uncharacterized protein. (81 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AR	ARID1A	ENSUAMP00000013075	ENSUAMP00000034428	Androgen receptor.	AT-rich interaction domain 1A.	0.420
AR	DAXX	ENSUAMP00000013075	ENSUAMP00000035494	Androgen receptor.	Death domain associated protein.	0.436
AR	DDX5	ENSUAMP00000013075	ENSUAMP00000030459	Androgen receptor.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.521
AR	ENSUAMP00000004918	ENSUAMP00000013075	ENSUAMP00000004918	Androgen receptor.	Homeobox domain-containing protein.	0.575
AR	ENSUAMP00000012231	ENSUAMP00000013075	ENSUAMP00000012231	Androgen receptor.	Uncharacterized protein.	0.586
AR	ENSUAMP00000016402	ENSUAMP00000013075	ENSUAMP00000016402	Androgen receptor.	Uncharacterized protein.	0.544
AR	ESR1	ENSUAMP00000013075	ENSUAMP00000006270	Androgen receptor.	Estrogen receptor 1.	0.587
AR	MED1	ENSUAMP00000013075	ENSUAMP00000034047	Androgen receptor.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.613
AR	NR3C1	ENSUAMP00000013075	ENSUAMP00000029768	Androgen receptor.	Nuclear receptor subfamily 3 group C member 1.	0.582
AR	PGR	ENSUAMP00000013075	ENSUAMP00000000820	Androgen receptor.	Progesterone receptor.	0.618
AR	SRC	ENSUAMP00000013075	ENSUAMP00000030149	Androgen receptor.	Tyrosine-protein kinase.	0.603
ARID1A	AR	ENSUAMP00000034428	ENSUAMP00000013075	AT-rich interaction domain 1A.	Androgen receptor.	0.420
ARID1A	KDM3A	ENSUAMP00000034428	ENSUAMP00000024861	AT-rich interaction domain 1A.	Lysine demethylase 3A.	0.915
DAXX	AR	ENSUAMP00000035494	ENSUAMP00000013075	Death domain associated protein.	Androgen receptor.	0.436
DAXX	NR3C1	ENSUAMP00000035494	ENSUAMP00000029768	Death domain associated protein.	Nuclear receptor subfamily 3 group C member 1.	0.497
DDX17	DDX5	ENSUAMP00000008715	ENSUAMP00000030459	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	0.883
DDX17	ESR1	ENSUAMP00000008715	ENSUAMP00000006270	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	Estrogen receptor 1.	0.783
DDX5	AR	ENSUAMP00000030459	ENSUAMP00000013075	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Androgen receptor.	0.521
DDX5	DDX17	ENSUAMP00000030459	ENSUAMP00000008715	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	DEAD-box helicase 17; Belongs to the DEAD box helicase family.	0.883
DDX5	ESR1	ENSUAMP00000030459	ENSUAMP00000006270	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Estrogen receptor 1.	0.828