STRINGSTRING
ENSUAMP00000037248 ENSUAMP00000037248 LSM6 LSM6 ENSUAMP00000019788 ENSUAMP00000019788 SNRNP70 SNRNP70 SNRPN SNRPN ENSUAMP00000020708 ENSUAMP00000020708 ENSUAMP00000020803 ENSUAMP00000020803 ENSUAMP00000021056 ENSUAMP00000021056 LSM3 LSM3 ENSUAMP00000021996 ENSUAMP00000021996 ENSUAMP00000021998 ENSUAMP00000021998 SNRNP40 SNRNP40 SNRPB2 SNRPB2 PRPF4 PRPF4 SF3B1 SF3B1 DDX39A DDX39A FMC1-LUC7L2 FMC1-LUC7L2 LSM10 LSM10 ENSUAMP00000026187 ENSUAMP00000026187 TXNL4B TXNL4B RBM42 RBM42 SF3B2 SF3B2 SART1 SART1 ENSUAMP00000026961 ENSUAMP00000026961 ARFGEF1 ARFGEF1 ENSUAMP00000028028 ENSUAMP00000028028 ENSUAMP00000028083 ENSUAMP00000028083 SNRPD2-2 SNRPD2-2 PHF5A PHF5A SNRPD2-3 SNRPD2-3 SART3 SART3 HEXIM1 HEXIM1 SNRPC SNRPC SNRPD1 SNRPD1 LSM11 LSM11 ENSUAMP00000016259 ENSUAMP00000016259 HTATSF1 HTATSF1 ENSUAMP00000014318 ENSUAMP00000014318 SNRPD3 SNRPD3 SNRPE SNRPE LSM5 LSM5 SNRPA1 SNRPA1 ENSUAMP00000011638 ENSUAMP00000011638 LUC7L3 LUC7L3 PRPF3 PRPF3 ENSUAMP00000011444 ENSUAMP00000011444 ENSUAMP00000010169 ENSUAMP00000010169 ENSUAMP00000010166 ENSUAMP00000010166 ENSUAMP00000010072 ENSUAMP00000010072 SNRPD2 SNRPD2 SNRPF SNRPF LSM8-2 LSM8-2 LSM8 LSM8 SF3B3 SF3B3 SF3A1 SF3A1 SF3A3 SF3A3 ENSUAMP00000006861 ENSUAMP00000006861 ENSUAMP00000005947 ENSUAMP00000005947 PRPF31 PRPF31 ZMAT2 ZMAT2 TXNL4A TXNL4A SNU13 SNU13 ENSUAMP00000003688 ENSUAMP00000003688 ENSUAMP00000003643 ENSUAMP00000003643 ENSUAMP00000003273 ENSUAMP00000003273 C19orf54 C19orf54 ENSUAMP00000003208 ENSUAMP00000003208 PRPF6 PRPF6 LUC7L LUC7L ENSUAMP00000001968 ENSUAMP00000001968 LARP7 LARP7 ENSUAMP00000001138 ENSUAMP00000001138 ENSUAMP00000000999 ENSUAMP00000000999 ENSUAMP00000001028 ENSUAMP00000001028 SNRNP27 SNRNP27 ENSUAMP00000000623 ENSUAMP00000000623 EFTUD2 EFTUD2 LSM4 LSM4 LSM7 LSM7 RBMX2 RBMX2 ENSUAMP00000033230 ENSUAMP00000033230 PRPF39 PRPF39 ENSUAMP00000033911 ENSUAMP00000033911 MEPCE MEPCE DDX23 DDX23 SF3B5 SF3B5 DDX39B DDX39B CD2BP2 CD2BP2 USP39 USP39
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000037248MPN domain-containing protein. (979 aa)
LSM6LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated. (122 aa)
ENSUAMP00000019788Uncharacterized protein. (1338 aa)
SNRNP70Small nuclear ribonucleoprotein U1 subunit 70. (438 aa)
SNRPNSmall nuclear ribonucleoprotein polypeptide N. (287 aa)
ENSUAMP00000020708Sm domain-containing protein. (74 aa)
ENSUAMP00000020803Uncharacterized protein. (278 aa)
ENSUAMP00000021056Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (153 aa)
LSM3U6 snRNA-associated Sm-like protein LSm3; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (114 aa)
ENSUAMP00000021996Uncharacterized protein. (126 aa)
ENSUAMP00000021998Uncharacterized protein. (380 aa)
SNRNP40Small nuclear ribonucleoprotein U5 subunit 40. (358 aa)
SNRPB2Small nuclear ribonucleoprotein polypeptide B2. (224 aa)
PRPF4Pre-mRNA processing factor 4. (369 aa)
SF3B1Splicing factor 3b subunit 1. (1122 aa)
DDX39ADExD-box helicase 39A. (427 aa)
FMC1-LUC7L2FMC1-LUC7L2 readthrough. (392 aa)
LSM10LSM10, U7 small nuclear RNA associated. (123 aa)
ENSUAMP00000026187Sm domain-containing protein. (72 aa)
TXNL4BThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (149 aa)
RBM42RNA binding motif protein 42. (477 aa)
SF3B2Splicing factor 3b subunit 2. (910 aa)
SART1Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (765 aa)
ENSUAMP00000026961Uncharacterized protein. (113 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1596 aa)
ENSUAMP00000028028Sm domain-containing protein. (48 aa)
ENSUAMP00000028083Uncharacterized protein. (88 aa)
SNRPD2-2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (123 aa)
PHF5APHD finger protein 5A. (85 aa)
SNRPD2-3Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (118 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (964 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (247 aa)
SNRPCU1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. Belongs to the U1 [...] (148 aa)
SNRPD1Small nuclear ribonucleoprotein Sm D1; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA. (117 aa)
LSM11LSM11, U7 small nuclear RNA associated. (335 aa)
ENSUAMP00000016259Uncharacterized protein. (194 aa)
HTATSF1HIV-1 Tat specific factor 1. (750 aa)
ENSUAMP00000014318RRM domain-containing protein. (88 aa)
SNRPD3Small nuclear ribonucleoprotein Sm D3; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing. (126 aa)
SNRPESmall nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (88 aa)
LSM5LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated. (77 aa)
SNRPA1Small nuclear ribonucleoprotein polypeptide A. (257 aa)
ENSUAMP00000011638Uncharacterized protein. (80 aa)
LUC7L3LUC7 like 3 pre-mRNA splicing factor. (413 aa)
PRPF3Pre-mRNA processing factor 3. (548 aa)
ENSUAMP00000011444PWI domain-containing protein. (112 aa)
ENSUAMP00000010169Uncharacterized protein. (1045 aa)
ENSUAMP00000010166SEC63 domain-containing protein. (329 aa)
ENSUAMP00000010072Sm domain-containing protein. (105 aa)
SNRPD2Small nuclear ribonucleoprotein Sm D2; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. (53 aa)
SNRPFSm domain-containing protein. (86 aa)
LSM8-2U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (96 aa)
LSM8U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. (92 aa)
SF3B3Splicing factor 3b subunit 3. (1217 aa)
SF3A1Splicing factor 3a subunit 1. (795 aa)
SF3A3Splicing factor 3a subunit 3. (501 aa)
ENSUAMP00000006861Sm domain-containing protein. (52 aa)
ENSUAMP00000005947annotation not available (78 aa)
PRPF31Pre-mRNA processing factor 31. (499 aa)
ZMAT2Zinc finger matrin-type 2. (192 aa)
TXNL4AThioredoxin-like protein; Plays role in pre-mRNA splicing. Belongs to the DIM1 family. (188 aa)
SNU13Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (128 aa)
ENSUAMP00000003688Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (78 aa)
ENSUAMP00000003643Small nuclear ribonucleoprotein E; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development. (72 aa)
ENSUAMP00000003273RRM domain-containing protein. (92 aa)
C19orf54Chromosome 19 open reading frame 54. (346 aa)
ENSUAMP00000003208Uncharacterized protein. (57 aa)
PRPF6Pre-mRNA processing factor 6. (758 aa)
LUC7LLUC7 like. (364 aa)
ENSUAMP00000001968SFM domain-containing protein. (335 aa)
LARP7La ribonucleoprotein domain family member 7. (581 aa)
ENSUAMP00000001138Sm domain-containing protein. (85 aa)
ENSUAMP00000000999RRM domain-containing protein. (126 aa)
ENSUAMP00000001028SF3A2 domain-containing protein. (192 aa)
SNRNP27Small nuclear ribonucleoprotein U4/U6.U5 subunit 27. (155 aa)
ENSUAMP00000000623Uncharacterized protein. (86 aa)
EFTUD2Elongation factor Tu GTP binding domain containing 2. (970 aa)
LSM4U6 snRNA-associated Sm-like protein LSm4; Binds specifically to the 3'-terminal U-tract of U6 snRNA. (139 aa)
LSM7LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated. (120 aa)
RBMX2RNA binding motif protein X-linked 2. (311 aa)
ENSUAMP00000033230RRM domain-containing protein. (125 aa)
PRPF39Pre-mRNA processing factor 39. (667 aa)
ENSUAMP00000033911Small nuclear ribonucleoprotein G; Plays role in pre-mRNA splicing as core component of the SMN- Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing. (76 aa)
MEPCEMethylphosphate capping enzyme. (653 aa)
DDX23DEAD-box helicase 23. (820 aa)
SF3B5Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
DDX39BDExD-box helicase 39B. (412 aa)
CD2BP2CD2 cytoplasmic tail binding protein 2. (363 aa)
USP39Ubiquitin specific peptidase 39. (562 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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