(108 nodes) Adult behavior network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GLRB	Glycine receptor beta; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (306 aa)
	ENSUAMP00000000624	NGF domain-containing protein; Belongs to the NGF-beta family. (211 aa)
	ENSUAMP00000001033	Uncharacterized protein. (106 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1200 aa)
	ENSUAMP00000001869	Uncharacterized protein. (78 aa)
	BTBD9	BTB domain containing 9. (391 aa)
	ENSUAMP00000002126	zf-RING_14 domain-containing protein. (110 aa)
	ENSUAMP00000002297	Eph LBD domain-containing protein. (286 aa)
	ENSUAMP00000003762	COesterase domain-containing protein. (115 aa)
	DMBX1	Diencephalon/mesencephalon homeobox 1. (375 aa)
	OPRM1	Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (450 aa)
	ENSUAMP00000004823	SH3 domain-containing protein. (506 aa)
	LGI4	Leucine rich repeat LGI family member 4. (615 aa)
	DRD3	Dopamine receptor D3; Belongs to the G-protein coupled receptor 1 family. (439 aa)
	CARTPT	CART prepropeptide. (128 aa)
	CNTN2	Contactin 2. (1045 aa)
	EFNB3	Ephrin B3. (180 aa)
	TMOD1	Tropomodulin 1. (359 aa)
	KCNMA1	Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
	ENSUAMP00000006851	RBR-type E3 ubiquitin transferase. (137 aa)
	ENSUAMP00000006884	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
	APP	Amyloid beta precursor protein. (735 aa)
	KLHL5	Kelch like family member 5. (707 aa)
	ZFHX2	Zinc finger homeobox 2. (2566 aa)
	TPGS1	Tubulin polyglutamylase complex subunit 1. (291 aa)
	ARCN1	Coatomer subunit delta; The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin- coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (511 aa)
	GLRA1	Glycine receptor alpha 1; Belongs to the ligand-gated ion channel (TC 1.A.9) family. (472 aa)
	NPY	Neuropeptide Y. (90 aa)
	KLHL4	Kelch like family member 4. (569 aa)
	PPP1R1B	Protein phosphatase 1 regulatory inhibitor subunit 1B. (169 aa)
	PREX2	Phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2. (1261 aa)
	ENSUAMP00000011906	Uncharacterized protein. (528 aa)
	OPRD1	Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
	ENSUAMP00000012241	zf-RING_14 domain-containing protein. (109 aa)
	HOMER2	Homer scaffold protein 2. (341 aa)
	ENSUAMP00000013955	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. (378 aa)
	SLITRK1	SLIT and NTRK like family member 1. (696 aa)
	KCNJ10	Potassium voltage-gated channel subfamily J member 10. (379 aa)
	NR4A2	Nuclear receptor subfamily 4 group A member 2. (598 aa)
	NCSTN	Nicastrin. (709 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	NTSR1	Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
	PAFAH1B1	Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
	ENSUAMP00000016331	Ubiquitin-like domain-containing protein. (153 aa)
	CLCN3	Chloride channel protein. (866 aa)
	DMRT3	Doublesex and mab-3 related transcription factor 3. (476 aa)
	PCDH17	Protocadherin 17. (1162 aa)
	CTNS	Cystinosin, lysosomal cystine transporter. (388 aa)
	UNC79	Unc-79 homolog, NALCN channel complex subunit. (2455 aa)
	SPTBN2	Spectrin beta chain; Belongs to the spectrin family. (2171 aa)
	CHRNB2	Cholinergic receptor nicotinic beta 2 subunit. (463 aa)
	NLGN3	Neuroligin 3. (789 aa)
	CHRNB1	Cholinergic receptor nicotinic beta 1 subunit. (576 aa)
	ENSUAMP00000018782	BBS1 domain-containing protein. (623 aa)
	ALK	Tyrosine-protein kinase receptor. (1234 aa)
	SEZ6	Seizure related 6 homolog. (969 aa)
	ENSUAMP00000019968	Uncharacterized protein. (223 aa)
	AGRP	Agouti related neuropeptide. (131 aa)
	ENSUAMP00000020340	WH1 domain-containing protein. (244 aa)
	ENSUAMP00000021280	Uncharacterized protein. (128 aa)
	ENSUAMP00000021522	Uncharacterized protein. (246 aa)
	ENSUAMP00000021529	Uncharacterized protein. (906 aa)
	MAFG	MAF bZIP transcription factor G. (162 aa)
	BBS2	Bardet-Biedl syndrome 2 protein homolog. (721 aa)
	LEP	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (157 aa)
	CHRNA3	Cholinergic receptor nicotinic alpha 3 subunit. (500 aa)
	CHRNA5	Cholinergic receptor nicotinic alpha 5 subunit. (453 aa)
	ENSUAMP00000022968	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (422 aa)
	PUM1	PUM-HD domain-containing protein. (1082 aa)
	ENSUAMP00000023294	Uncharacterized protein. (67 aa)
	ENSUAMP00000023330	Bravo_FIGEY domain-containing protein. (175 aa)
	GHSR	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
	RNF180	Ring finger protein 180. (544 aa)
	ATP6V1B1	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family. (528 aa)
	SLC7A11	Solute carrier family 7 member 11. (466 aa)
	CHL1	Cell adhesion molecule L1 like. (975 aa)
	SHANK2	SH3 and multiple ankyrin repeat domains 2. (1832 aa)
	OXR1	Oxidation resistance 1. (873 aa)
	ABAT	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (522 aa)
	MECP2	Methyl-CpG binding protein 2. (440 aa)
	SLC1A2	Amino acid transporter. (565 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	HOXB8	Homeobox B8. (243 aa)
	CEND1	Cell cycle exit and neuronal differentiation 1. (149 aa)
	DRD4	Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (364 aa)
	ENSUAMP00000029334	Uncharacterized protein. (124 aa)
	CDK5	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
	TSHR	Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (764 aa)
	ENSUAMP00000030105	Uncharacterized protein. (165 aa)
	GIP	Gastric inhibitory polypeptide. (176 aa)
	ENSUAMP00000031281	Uncharacterized protein. (466 aa)
	SEZ6L2	Seizure related 6 homolog like 2. (923 aa)
	EHMT2	Euchromatic histone lysine methyltransferase 2. (1294 aa)
	CNP	2',3'-cyclic nucleotide 3' phosphodiesterase. (420 aa)
	HOMER1	Homer scaffold protein 1. (191 aa)
	CHRNA4	Cholinergic receptor nicotinic alpha 4 subunit. (624 aa)
	INPP5F	Inositol polyphosphate-5-phosphatase F. (817 aa)
	ENSUAMP00000032923	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
	BBS4	Uncharacterized protein. (384 aa)
	HOXD10	Homeobox D10. (410 aa)
	HOXD9	Homeobox D9. (341 aa)
	ENSUAMP00000033771	Beta-hexosaminidase. (529 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2987 aa)
	ENSUAMP00000034037	SH3 domain-containing protein. (437 aa)
	CRHBP	Corticotropin releasing hormone binding protein. (315 aa)
	SLITRK5	SLIT and NTRK like family member 5. (958 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
	ENSUAMP00000036326	Uncharacterized protein. (630 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABAT	ENSUAMP00000013955	ENSUAMP00000026174	ENSUAMP00000013955	4-aminobutyrate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.	Septin-type G domain-containing protein; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.	0.533
AGRP	CARTPT	ENSUAMP00000020167	ENSUAMP00000005831	Agouti related neuropeptide.	CART prepropeptide.	0.634
AGRP	GHSR	ENSUAMP00000020167	ENSUAMP00000023689	Agouti related neuropeptide.	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	0.529
AGRP	LEP	ENSUAMP00000020167	ENSUAMP00000022211	Agouti related neuropeptide.	Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...]	0.956
AGRP	NPY	ENSUAMP00000020167	ENSUAMP00000010400	Agouti related neuropeptide.	Neuropeptide Y.	0.968
ALK	ENSUAMP00000032923	ENSUAMP00000019646	ENSUAMP00000032923	Tyrosine-protein kinase receptor.	Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family.	0.558
APP	CDK5	ENSUAMP00000006953	ENSUAMP00000029542	Amyloid beta precursor protein.	Cyclin dependent kinase 5; Belongs to the protein kinase superfamily.	0.531
APP	CNTN2	ENSUAMP00000006953	ENSUAMP00000006039	Amyloid beta precursor protein.	Contactin 2.	0.704
APP	GHSR	ENSUAMP00000006953	ENSUAMP00000023689	Amyloid beta precursor protein.	Growth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family.	0.554
APP	NCSTN	ENSUAMP00000006953	ENSUAMP00000015494	Amyloid beta precursor protein.	Nicastrin.	0.965
APP	PARK7	ENSUAMP00000006953	ENSUAMP00000015926	Amyloid beta precursor protein.	Parkinsonism associated deglycase.	0.520
ATP6V1B1	OXR1	ENSUAMP00000024174	ENSUAMP00000025085	Vacuolar proton pump subunit B; Non-catalytic subunit of the peripheral V1 complex of vacuolar ATPase; Belongs to the ATPase alpha/beta chains family.	Oxidation resistance 1.	0.558
BBS2	BBS4	ENSUAMP00000021587	ENSUAMP00000033668	Bardet-Biedl syndrome 2 protein homolog.	Uncharacterized protein.	0.999
BBS2	ENSUAMP00000018782	ENSUAMP00000021587	ENSUAMP00000018782	Bardet-Biedl syndrome 2 protein homolog.	BBS1 domain-containing protein.	0.999
BBS2	ENSUAMP00000030105	ENSUAMP00000021587	ENSUAMP00000030105	Bardet-Biedl syndrome 2 protein homolog.	Uncharacterized protein.	0.940
BBS4	BBS2	ENSUAMP00000033668	ENSUAMP00000021587	Uncharacterized protein.	Bardet-Biedl syndrome 2 protein homolog.	0.999
BBS4	ENSUAMP00000004823	ENSUAMP00000033668	ENSUAMP00000004823	Uncharacterized protein.	SH3 domain-containing protein.	0.403
BBS4	ENSUAMP00000018782	ENSUAMP00000033668	ENSUAMP00000018782	Uncharacterized protein.	BBS1 domain-containing protein.	0.999
BBS4	ENSUAMP00000019968	ENSUAMP00000033668	ENSUAMP00000019968	Uncharacterized protein.	Uncharacterized protein.	0.474
BBS4	ENSUAMP00000030105	ENSUAMP00000033668	ENSUAMP00000030105	Uncharacterized protein.	Uncharacterized protein.	0.942