16 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GREB1L	GREB1 like retinoic acid receptor coactivator. (1923 aa)
	HOXD13	Homeobox D13. (333 aa)
	WNT9B	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
	DHCR24	24-dehydrocholesterol reductase. (516 aa)
	ASB1	Ankyrin repeat and SOCS box containing 1. (328 aa)
	GREB1	Uncharacterized protein. (1953 aa)
	ENSUAMP00000008515	Uncharacterized protein. (148 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	SRD5A2	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (254 aa)
	LGR4	Leucine rich repeat containing G protein-coupled receptor 4. (971 aa)
	SYCP2	Synaptonemal complex protein 2. (1469 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	ENSUAMP00000027938	Uncharacterized protein. (110 aa)
	KLHL10	Kelch like family member 10. (608 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DHCR24	ENSUAMP00000008515	ENSUAMP00000013694	ENSUAMP00000008515	24-dehydrocholesterol reductase.	Uncharacterized protein.	0.414
DHCR24	ENSUAMP00000027938	ENSUAMP00000013694	ENSUAMP00000027938	24-dehydrocholesterol reductase.	Uncharacterized protein.	0.414
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000008515	DHCR24	ENSUAMP00000008515	ENSUAMP00000013694	Uncharacterized protein.	24-dehydrocholesterol reductase.	0.414
ENSUAMP00000008515	ENSUAMP00000027938	ENSUAMP00000008515	ENSUAMP00000027938	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSUAMP00000008515	SRD5A2	ENSUAMP00000008515	ENSUAMP00000014418	Uncharacterized protein.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.936
ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000027938	DHCR24	ENSUAMP00000027938	ENSUAMP00000013694	Uncharacterized protein.	24-dehydrocholesterol reductase.	0.414
ENSUAMP00000027938	ENSUAMP00000008515	ENSUAMP00000027938	ENSUAMP00000008515	Uncharacterized protein.	Uncharacterized protein.	0.899
ENSUAMP00000027938	SRD5A2	ENSUAMP00000027938	ENSUAMP00000014418	Uncharacterized protein.	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	0.936
FGF10	PDGFRA	ENSUAMP00000008288	ENSUAMP00000018884	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.956
PDGFRA	FGF10	ENSUAMP00000018884	ENSUAMP00000008288	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.956
SRD5A2	ENSUAMP00000008515	ENSUAMP00000014418	ENSUAMP00000008515	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Uncharacterized protein.	0.936
SRD5A2	ENSUAMP00000027938	ENSUAMP00000014418	ENSUAMP00000027938	3-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology.	Uncharacterized protein.	0.936