STRINGSTRING
FOXN1 FOXN1 LHX1 LHX1 ENSUAMP00000036078 ENSUAMP00000036078 ENSUAMP00000036061 ENSUAMP00000036061 WNT10B WNT10B VDR VDR KDF1 KDF1 SFN SFN NOTCH1 NOTCH1 MED1 MED1 AHI1 AHI1 TMEM100 TMEM100 ENSUAMP00000030353 ENSUAMP00000030353 ENSUAMP00000029322 ENSUAMP00000029322 BMP4 BMP4 ENSUAMP00000026773 ENSUAMP00000026773 ENSUAMP00000026772 ENSUAMP00000026772 SOX9 SOX9 PAX8 PAX8 ATOH7 ATOH7 NCOA3 NCOA3 ETV4 ETV4 PROM1 PROM1 PTCH2 PTCH2 GDNF GDNF ZBED2 ZBED2 BMP2 BMP2 BAD BAD ATOH1 ATOH1 ENSUAMP00000017792 ENSUAMP00000017792 ACVRL1 ACVRL1 MACROH2A1 MACROH2A1 CYP27B1 CYP27B1 PAX4 PAX4 ATOH8 ATOH8 TP73 TP73 BTG1 BTG1 CYP27C1 CYP27C1 SFRP4 SFRP4 ENSUAMP00000008298 ENSUAMP00000008298 LIF LIF PTCH1 PTCH1 ALOX15B ALOX15B MACROH2A2 MACROH2A2 FOXJ1 FOXJ1 ENSUAMP00000000397 ENSUAMP00000000397 ENSUAMP00000000316 ENSUAMP00000000316 GDF2 GDF2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXN1Forkhead box N1. (634 aa)
LHX1LIM homeobox 1. (406 aa)
ENSUAMP00000036078Uncharacterized protein. (258 aa)
ENSUAMP00000036061Uncharacterized protein. (1711 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
VDRVitamin D receptor. (427 aa)
KDF1Keratinocyte differentiation factor 1. (397 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
NOTCH1Notch receptor 1. (2547 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
AHI1Abelson helper integration site 1. (1054 aa)
TMEM100Transmembrane protein 100. (134 aa)
ENSUAMP00000030353C2 domain-containing protein. (165 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ENSUAMP00000026773Uncharacterized protein. (179 aa)
ENSUAMP00000026772ETS domain-containing protein. (163 aa)
SOX9SRY-box transcription factor 9. (484 aa)
PAX8Paired box 8. (458 aa)
ATOH7Atonal bHLH transcription factor 7. (149 aa)
NCOA3Nuclear receptor coactivator. (1431 aa)
ETV4ETS variant 4. (462 aa)
PROM1Prominin 1. (812 aa)
PTCH2Patched 2. (1207 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
ZBED2Zinc finger BED-type containing 2. (217 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
BADBCL2 associated agonist of cell death. (168 aa)
ATOH1Atonal bHLH transcription factor 1. (356 aa)
ENSUAMP00000017792Uncharacterized protein. (558 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
MACROH2A1Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
CYP27B1Cytochrome P450 family 27 subfamily B member 1; Belongs to the cytochrome P450 family. (508 aa)
PAX4Paired box 4. (357 aa)
ATOH8Atonal bHLH transcription factor 8. (322 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
BTG1BTG anti-proliferation factor 1. (155 aa)
CYP27C1Cytochrome P450 family 27 subfamily C member 1; Belongs to the cytochrome P450 family. (372 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
ENSUAMP00000008298AGC-kinase C-terminal domain-containing protein. (89 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
PTCH1Patched 1. (1453 aa)
ALOX15BArachidonate 15-lipoxygenase type B. (687 aa)
MACROH2A2H2A histone family member Y2; Belongs to the histone H2A family. (392 aa)
FOXJ1Forkhead box J1. (421 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
GDF2Growth differentiation factor 2. (429 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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