82 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	MSX1	Msh homeobox 1. (303 aa)
	ENSUAMP00000001020	Uncharacterized protein. (147 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	PRL	Prolactin. (245 aa)
	ENSUAMP00000003081	Uncharacterized protein. (413 aa)
	LRRC1	Leucine rich repeat containing 1. (435 aa)
	ATP2C2	Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (931 aa)
	ESR1	Estrogen receptor 1. (490 aa)
	LATS1	Uncharacterized protein. (1012 aa)
	TNFSF11	TNF superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
	ORAI1	ORAI calcium release-activated calcium modulator 1. (305 aa)
	PTCH1	Patched 1. (1453 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	CAV1	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
	WNT2	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
	GPAT4	Glycerol-3-phosphate acyltransferase 4. (456 aa)
	GHRHR	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (422 aa)
	ENSUAMP00000012266	CTNNB1_binding domain-containing protein. (162 aa)
	WNT3A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
	MAPK1	Mitogen-activated protein kinase. (364 aa)
	ENSUAMP00000013585	Uncharacterized protein. (588 aa)
	STAT5A	Signal transducer and activator of transcription. (797 aa)
	FOXF1	Forkhead box F1. (379 aa)
	AREG	Amphiregulin. (257 aa)
	AGAP2	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2. (733 aa)
	IQGAP3	IQ motif containing GTPase activating protein 3. (1630 aa)
	SOSTDC1	Sclerostin domain containing 1. (206 aa)
	SLC6A3	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	HOXA5	Homeobox A5. (381 aa)
	ENSUAMP00000017946	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
	PYGO2	Pygopus family PHD finger 2. (369 aa)
	ZBTB7B	Zinc finger and BTB domain containing 7B. (507 aa)
	ENSUAMP00000018330	Uncharacterized protein. (346 aa)
	EPHA2	EPH receptor A2. (966 aa)
	USF2	Upstream transcription factor 2, c-fos interacting. (335 aa)
	NOTCH4	Notch receptor 4. (1894 aa)
	IRF6	Interferon regulatory factor 6. (462 aa)
	ENSUAMP00000021186	Uncharacterized protein. (404 aa)
	NEURL1	Neuralized E3 ubiquitin protein ligase 1. (575 aa)
	ENSUAMP00000023517	Laminin N-terminal domain-containing protein. (378 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	ENSUAMP00000025368	TNFR-Cys domain-containing protein. (263 aa)
	ENSUAMP00000025370	Uncharacterized protein. (358 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	ELF3	E74 like ETS transcription factor 3. (369 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	ENSUAMP00000027148	Uncharacterized protein. (221 aa)
	CEBPB	CCAAT/enhancer-binding protein. (346 aa)
	STAT6	Signal transducer and activator of transcription. (844 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	HOXB9	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (250 aa)
	BSX	Brain specific homeobox. (232 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	CSF1	Colony stimulating factor 1. (518 aa)
	ENSUAMP00000029322	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
	BCL2L11	BCL2 like 11. (140 aa)
	SRC	Tyrosine-protein kinase. (557 aa)
	ZNF703	Zinc finger protein 703. (592 aa)
	STAT5B	Signal transducer and activator of transcription. (784 aa)
	BTRC	Beta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
	GLI3	GLI family zinc finger 3. (1413 aa)
	FASN	Fatty acid synthase. (2519 aa)
	KDM5B	Lysine demethylase 5B. (1039 aa)
	CSN2	Casein beta. (220 aa)
	ENSUAMP00000033009	Uncharacterized protein. (1337 aa)
	PML	Promyelocytic leukemia. (877 aa)
	FOXB1	Forkhead box B1. (325 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	HOXD9	Homeobox D9. (341 aa)
	RXFP1	Relaxin family peptide receptor 1. (724 aa)
	ARHGAP35	Rho GTPase activating protein 35. (1500 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	DDR1	Discoidin domain receptor tyrosine kinase 1. (936 aa)
	HIF1A	Hypoxia inducible factor 1 subunit alpha. (823 aa)
	VDR	Vitamin D receptor. (427 aa)
	PHB2	Prohibitin. (297 aa)
	ENSUAMP00000035777	HMG box domain-containing protein. (191 aa)
	WNT3	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGAP2	ENSUAMP00000003081	ENSUAMP00000016525	ENSUAMP00000003081	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	Uncharacterized protein.	0.899
AGAP2	NEURL1	ENSUAMP00000016525	ENSUAMP00000023098	ArfGAP with GTPase domain, ankyrin repeat and PH domain 2.	Neuralized E3 ubiquitin protein ligase 1.	0.534
AREG	ENSUAMP00000001020	ENSUAMP00000016267	ENSUAMP00000001020	Amphiregulin.	Uncharacterized protein.	0.790
AREG	EPHA2	ENSUAMP00000016267	ENSUAMP00000018573	Amphiregulin.	EPH receptor A2.	0.909
AREG	ESR1	ENSUAMP00000016267	ENSUAMP00000006270	Amphiregulin.	Estrogen receptor 1.	0.435
AREG	SRC	ENSUAMP00000016267	ENSUAMP00000030149	Amphiregulin.	Tyrosine-protein kinase.	0.684
ARHGAP35	SRC	ENSUAMP00000033899	ENSUAMP00000030149	Rho GTPase activating protein 35.	Tyrosine-protein kinase.	0.949
BCL2L11	BTRC	ENSUAMP00000029698	ENSUAMP00000031418	BCL2 like 11.	Beta-transducin repeat containing E3 ubiquitin protein ligase.	0.557
BCL2L11	MAPK1	ENSUAMP00000029698	ENSUAMP00000013584	BCL2 like 11.	Mitogen-activated protein kinase.	0.951
BMP4	ENSUAMP00000000600	ENSUAMP00000028868	ENSUAMP00000000600	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	ENSUAMP00000012266	ENSUAMP00000028868	ENSUAMP00000012266	Bone morphogenetic protein 4.	CTNNB1_binding domain-containing protein.	0.525
BMP4	ENSUAMP00000017830	ENSUAMP00000028868	ENSUAMP00000017830	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	ENSUAMP00000029322	ENSUAMP00000028868	ENSUAMP00000029322	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.753
BMP4	ENSUAMP00000035777	ENSUAMP00000028868	ENSUAMP00000035777	Bone morphogenetic protein 4.	HMG box domain-containing protein.	0.525
BMP4	FGF10	ENSUAMP00000028868	ENSUAMP00000008288	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.758
BMP4	FOXF1	ENSUAMP00000028868	ENSUAMP00000016230	Bone morphogenetic protein 4.	Forkhead box F1.	0.500
BMP4	MSX1	ENSUAMP00000028868	ENSUAMP00000000613	Bone morphogenetic protein 4.	Msh homeobox 1.	0.628
BMP4	PTCH1	ENSUAMP00000028868	ENSUAMP00000007757	Bone morphogenetic protein 4.	Patched 1.	0.528
BMP4	SOX9	ENSUAMP00000028868	ENSUAMP00000026554	Bone morphogenetic protein 4.	SRY-box transcription factor 9.	0.606
BMP4	WNT3	ENSUAMP00000028868	ENSUAMP00000035954	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.650