STRINGSTRING
MAPK3 MAPK3 PIH1D1 PIH1D1 DNMT1 DNMT1 DMRTC2 DMRTC2 LIF LIF ENSUAMP00000005720 ENSUAMP00000005720 NSD3 NSD3 CHTOP CHTOP SAP30BP SAP30BP ZNF304 ZNF304 PAXIP1 PAXIP1 PHF19 PHF19 MYB MYB TP53 TP53 AKAP8L AKAP8L C6orf89 C6orf89 ENSUAMP00000036515 ENSUAMP00000036515 KANSL2 KANSL2 PHF1 PHF1 RIF1 RIF1 SDR16C5 SDR16C5 RRP8 RRP8 ENSUAMP00000032692 ENSUAMP00000032692 BRD7 BRD7 RTF1 RTF1 SART3 SART3 SMARCA5 SMARCA5 RPS6KA4 RPS6KA4 TADA2B TADA2B MTF2 MTF2 OGT OGT SNW1 SNW1 FOXP3 FOXP3 GATA3 GATA3 AUTS2 AUTS2 CTBP1 CTBP1 CTR9 CTR9 RNF20 RNF20 KMT2E KMT2E ENSUAMP00000026725 ENSUAMP00000026725 PAXBP1 PAXBP1 MECP2 MECP2 JARID2 JARID2 KAT7 KAT7 ENSUAMP00000023951 ENSUAMP00000023951 ARID5A ARID5A ENSUAMP00000023668 ENSUAMP00000023668 KANSL1 KANSL1 WDR61 WDR61 PRKD2 PRKD2 SIRT1 SIRT1 ENSUAMP00000021258 ENSUAMP00000021258 ING2 ING2 GLYR1 GLYR1 MCRS1 MCRS1 NIPBL NIPBL SMAD4 SMAD4 ZBTB7B ZBTB7B RPS6KA5 RPS6KA5 LMNA LMNA JDP2 JDP2 PHF20 PHF20 ENSUAMP00000016504 ENSUAMP00000016504 LRRK2 LRRK2 ENSUAMP00000015668 ENSUAMP00000015668 PINK1 PINK1 BCL6 BCL6 APLNR APLNR SMARCB1 SMARCB1 SPHK2 SPHK2 RUVBL2 RUVBL2 PAF1 PAF1 PRDM12 PRDM12 KAT8 KAT8 WDR5 WDR5 TADA2A TADA2A PRKD1 PRKD1 KPNA7 KPNA7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MAPK3Mitogen-activated protein kinase. (354 aa)
PIH1D1PIH1 domain containing 1. (290 aa)
DNMT1DNA methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (981 aa)
DMRTC2DMRT like family C2. (372 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
ENSUAMP00000005720Piwi domain-containing protein. (184 aa)
NSD3Nuclear receptor binding SET domain protein 3. (917 aa)
CHTOPChromatin target of PRMT1. (248 aa)
SAP30BPSAP30 binding protein. (301 aa)
ZNF304Zinc finger protein 304. (617 aa)
PAXIP1PAX interacting protein 1. (1017 aa)
PHF19PHD finger protein 19. (580 aa)
MYBMYB proto-oncogene, transcription factor. (727 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (645 aa)
C6orf89Chromosome 6 open reading frame 89. (331 aa)
ENSUAMP00000036515Uncharacterized protein. (78 aa)
KANSL2KAT8 regulatory NSL complex subunit 2. (492 aa)
PHF1PHD finger protein 1. (567 aa)
RIF1Replication timing regulatory factor 1. (2251 aa)
SDR16C5Short chain dehydrogenase/reductase family 16C member 5; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (309 aa)
RRP8Ribosomal RNA-processing protein 8; Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone- modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and pr [...] (457 aa)
ENSUAMP00000032692Uncharacterized protein. (218 aa)
BRD7Bromodomain containing 7. (674 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (424 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (964 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1047 aa)
RPS6KA4Ribosomal protein S6 kinase. (772 aa)
TADA2BTranscriptional adapter. (420 aa)
MTF2Metal response element binding transcription factor 2. (597 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (978 aa)
SNW1SNW domain containing 1. (511 aa)
FOXP3Forkhead box P3. (427 aa)
GATA3GATA binding protein 3. (444 aa)
AUTS2Activator of transcription and developmental regulator AUTS2. (983 aa)
CTBP1C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (421 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
RNF20E3 ubiquitin protein ligase; Belongs to the BRE1 family. (975 aa)
KMT2ELysine methyltransferase 2E. (1850 aa)
ENSUAMP00000026725SEA domain-containing protein. (629 aa)
PAXBP1PAX3 and PAX7 binding protein 1. (915 aa)
MECP2Methyl-CpG binding protein 2. (440 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1160 aa)
KAT7Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (592 aa)
ENSUAMP00000023951PWWP domain-containing protein. (538 aa)
ARID5AAT-rich interaction domain 5A. (437 aa)
ENSUAMP00000023668Uncharacterized protein. (113 aa)
KANSL1KAT8 regulatory NSL complex subunit 1. (662 aa)
WDR61WD repeat domain 61. (305 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (840 aa)
SIRT1Sirtuin 1. (618 aa)
ENSUAMP00000021258Uncharacterized protein. (129 aa)
ING2Inhibitor of growth protein. (280 aa)
GLYR1Glyoxylate reductase 1 homolog. (553 aa)
MCRS1Microspherule protein 1. (534 aa)
NIPBLNipped-B protein. (1833 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (507 aa)
RPS6KA5Ribosomal protein S6 kinase. (798 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (671 aa)
JDP2Jun dimerization protein 2. (187 aa)
PHF20PHD finger protein 20. (1001 aa)
ENSUAMP00000016504BRCT domain-containing protein. (101 aa)
LRRK2Leucine rich repeat kinase 2. (1967 aa)
ENSUAMP00000015668Uncharacterized protein. (104 aa)
PINK1PTEN induced kinase 1. (602 aa)
BCL6BCL6 transcription repressor. (706 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
SPHK2Sphingosine kinase 2. (662 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (525 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (528 aa)
PRDM12PR domain zinc finger protein 12; Involved in the positive regulation of histone H3-K9 dimethylation; Belongs to the class V-like SAM-binding methyltransferase superfamily. (361 aa)
KAT8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (458 aa)
WDR5WD repeat domain 5. (378 aa)
TADA2ATranscriptional adapter. (443 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (848 aa)
KPNA7Importin subunit alpha; Functions in nuclear protein import. (523 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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