88 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	JMJD1C	Jumonji domain containing 1C. (2510 aa)
	NUP50	Nucleoporin 50. (461 aa)
	EZH2	Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	OGT	O-linked N-acetylglucosamine (GlcNAc) transferase. (978 aa)
	REPIN1	Replication initiator 1. (829 aa)
	CREBBP	CREB binding protein. (2333 aa)
	EP300	E1A binding protein p300. (2399 aa)
	ENSUAMP00000032972	Uncharacterized protein. (102 aa)
	ENSUAMP00000034007	Uncharacterized protein. (113 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	PRDM14	PR/SET domain 14. (566 aa)
	ENSUAMP00000035332	H15 domain-containing protein. (170 aa)
	HSF1	Heat shock transcription factor 1. (554 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	TOX4	TOX high mobility group box family member 4. (611 aa)
	KDM6A	Lysine demethylase 6A. (1381 aa)
	H1-6	Histone cluster 1 H1 family member t. (209 aa)
	H1-4	Histone cluster 1 H1 family member e. (238 aa)
	SRF	Serum response factor. (507 aa)
	ATOH1	Atonal bHLH transcription factor 1. (356 aa)
	NR1H2	Nuclear receptor subfamily 1 group H member 2. (455 aa)
	ENSUAMP00000018852	Uncharacterized protein. (316 aa)
	SUZ12	SUZ12 polycomb repressive complex 2 subunit. (900 aa)
	MACROH2A1	Core histone macro-H2A; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. (371 aa)
	ENSUAMP00000017034	Uncharacterized protein. (1244 aa)
	ENSUAMP00000016112	TPR_REGION domain-containing protein. (215 aa)
	DHX9	DExH-box helicase 9. (1276 aa)
	ENSUAMP00000015788	BZIP domain-containing protein. (359 aa)
	BCL6	BCL6 transcription repressor. (706 aa)
	H1-3	Histone cluster 1 H1 family member d. (221 aa)
	RUVBL2	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (525 aa)
	WBP2NL	WBP2 N-terminal like. (276 aa)
	APEX1	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (318 aa)
	FOXO3B	Forkhead box O3B. (244 aa)
	FOXO3	Forkhead box O3. (453 aa)
	ENSUAMP00000011492	Uncharacterized protein. (116 aa)
	GATA1	GATA binding protein 1. (413 aa)
	TOX	Thymocyte selection associated high mobility group box. (526 aa)
	SBNO2	Strawberry notch homolog 2. (1219 aa)
	RCC1	Regulator of chromosome condensation 1. (432 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	TOX2	TOX high mobility group box family member 2. (535 aa)
	BAP1	Ubiquitin carboxyl-terminal hydrolase. (678 aa)
	MYOG	Myogenin. (224 aa)
	KDM5A	Lysine demethylase 5A. (1471 aa)
	ENSUAMP00000006843	Uncharacterized protein. (71 aa)
	H1-5	Histone cluster 1 H1 family member b. (226 aa)
	ENSUAMP00000006202	JmjC domain-containing protein. (934 aa)
	ENSUAMP00000005691	LEM domain-containing protein. (179 aa)
	ENSUAMP00000005686	MSC domain-containing protein. (201 aa)
	LEMD3	LEM domain containing 3. (929 aa)
	MACROH2A2	H2A histone family member Y2; Belongs to the histone H2A family. (392 aa)
	WBP2	WW domain binding protein 2. (279 aa)
	GALK1	Galactokinase 1. (392 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (447 aa)
	H1-8	H1 histone family member O oocyte specific. (327 aa)
	HR	HR lysine demethylase and nuclear receptor corepressor. (1181 aa)
	ENSUAMP00000000433	Uncharacterized protein. (114 aa)
	ENSUAMP00000000397	Paired domain-containing protein. (216 aa)
	ENSUAMP00000000316	Homeobox domain-containing protein. (280 aa)
	KDM3B	Lysine demethylase 3B. (1758 aa)
	H1-1	Histone cluster 1 H1 family member a. (212 aa)
	ENSUAMP00000020862	H15 domain-containing protein. (216 aa)
	POLE3	DNA polymerase epsilon 3, accessory subunit. (147 aa)
	ENSUAMP00000023895	Uncharacterized protein. (86 aa)
	VAX2	Ventral anterior homeobox 2. (296 aa)
	H1-10	H1 histone family member X. (213 aa)
	SIRT6	Sirtuin 6. (338 aa)
	KDM3A	Lysine demethylase 3A. (1323 aa)
	ATOH7	Atonal bHLH transcription factor 7. (149 aa)
	SBNO1	Strawberry notch homolog 1. (1393 aa)
	ENSUAMP00000025393	Uncharacterized protein. (173 aa)
	ENSUAMP00000025700	Uncharacterized protein. (72 aa)
	ENSUAMP00000025721	Uncharacterized protein. (113 aa)
	ENSUAMP00000025844	Uncharacterized protein. (269 aa)
	TBR1	T-box brain transcription factor 1. (682 aa)
	GRHL3	Grainyhead like transcription factor 3. (614 aa)
	ENSUAMP00000026245	ZAD domain-containing protein. (305 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (508 aa)
	PPARGC1A	PPARG coactivator 1 alpha. (761 aa)
	TOX3	TOX high mobility group box family member 3. (542 aa)
	CEBPB	CCAAT/enhancer-binding protein. (346 aa)
	HMGN4	High mobility group nucleosomal binding domain 4. (90 aa)
	THRB	Thyroid hormone receptor beta. (467 aa)
	ACTN4	Actinin alpha 4. (970 aa)
	GRHL1	Grainyhead like transcription factor 1. (600 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APEX1	CREBBP	ENSUAMP00000012960	ENSUAMP00000030777	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	CREB binding protein.	0.423
APEX1	EP300	ENSUAMP00000012960	ENSUAMP00000031856	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	E1A binding protein p300.	0.645
APEX1	HNRNPU	ENSUAMP00000012960	ENSUAMP00000029057	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	Heterogeneous nuclear ribonucleoprotein U.	0.507
APEX1	POLE3	ENSUAMP00000012960	ENSUAMP00000023224	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	DNA polymerase epsilon 3, accessory subunit.	0.606
APEX1	TOX4	ENSUAMP00000012960	ENSUAMP00000037106	DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.	TOX high mobility group box family member 4.	0.552
ATOH1	NOTCH1	ENSUAMP00000019050	ENSUAMP00000034225	Atonal bHLH transcription factor 1.	Notch receptor 1.	0.538
BAP1	EZH2	ENSUAMP00000007556	ENSUAMP00000028847	Ubiquitin carboxyl-terminal hydrolase.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.481
BAP1	OGT	ENSUAMP00000007556	ENSUAMP00000029133	Ubiquitin carboxyl-terminal hydrolase.	O-linked N-acetylglucosamine (GlcNAc) transferase.	0.902
BAP1	RUVBL2	ENSUAMP00000007556	ENSUAMP00000013223	Ubiquitin carboxyl-terminal hydrolase.	RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding.	0.615
BCL6	CREBBP	ENSUAMP00000014447	ENSUAMP00000030777	BCL6 transcription repressor.	CREB binding protein.	0.556
BCL6	ENSUAMP00000015788	ENSUAMP00000014447	ENSUAMP00000015788	BCL6 transcription repressor.	BZIP domain-containing protein.	0.748
BCL6	EP300	ENSUAMP00000014447	ENSUAMP00000031856	BCL6 transcription repressor.	E1A binding protein p300.	0.452
BCL6	EZH2	ENSUAMP00000014447	ENSUAMP00000028847	BCL6 transcription repressor.	Enhancer of zeste 2 polycomb repressive complex 2 subunit.	0.695
BCL6	STAT3	ENSUAMP00000014447	ENSUAMP00000008772	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.600
CEBPB	CREBBP	ENSUAMP00000027268	ENSUAMP00000030777	CCAAT/enhancer-binding protein.	CREB binding protein.	0.672
CEBPB	ENSUAMP00000015788	ENSUAMP00000027268	ENSUAMP00000015788	CCAAT/enhancer-binding protein.	BZIP domain-containing protein.	0.586
CEBPB	EP300	ENSUAMP00000027268	ENSUAMP00000031856	CCAAT/enhancer-binding protein.	E1A binding protein p300.	0.753
CEBPB	GATA1	ENSUAMP00000027268	ENSUAMP00000011093	CCAAT/enhancer-binding protein.	GATA binding protein 1.	0.480
CEBPB	MYOD1	ENSUAMP00000027268	ENSUAMP00000036900	CCAAT/enhancer-binding protein.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.431
CEBPB	PPARGC1A	ENSUAMP00000027268	ENSUAMP00000027059	CCAAT/enhancer-binding protein.	PPARG coactivator 1 alpha.	0.751