STRINGSTRING
PPM1F PPM1F ENSUAMP00000000033 ENSUAMP00000000033 ENSUAMP00000000062 ENSUAMP00000000062 LY86 LY86 IL18RAP IL18RAP ENSUAMP00000000518 ENSUAMP00000000518 NOD1 NOD1 HAVCR2 HAVCR2 CCR2 CCR2 FGF16 FGF16 ENSUAMP00000000885 ENSUAMP00000000885 ENSUAMP00000001223 ENSUAMP00000001223 ENSUAMP00000001501 ENSUAMP00000001501 CCL24 CCL24 CD226 CD226 IL33 IL33 ENSUAMP00000002230 ENSUAMP00000002230 SASH1 SASH1 FLNA FLNA NEDD9 NEDD9 S100A8 S100A8 S100A14 S100A14 ENSUAMP00000003947 ENSUAMP00000003947 XRCC5 XRCC5 LRSAM1 LRSAM1 SETD4 SETD4 SCG2 SCG2 PTK2B PTK2B PDGFB PDGFB F2RL1 F2RL1 FCN1 FCN1 UBE2K UBE2K TIRAP TIRAP ENSUAMP00000006398 ENSUAMP00000006398 ABCC1 ABCC1 ENSUAMP00000006607 ENSUAMP00000006607 OXSR1 OXSR1 P2RX4 P2RX4 CDH13 CDH13 TTBK1 TTBK1 CGAS CGAS APP APP TNFSF11 TNFSF11 ENSUAMP00000007290 ENSUAMP00000007290 ENSUAMP00000007291 ENSUAMP00000007291 MCU MCU LAMP1 LAMP1 PLCG2 PLCG2 ENSUAMP00000007852 ENSUAMP00000007852 OSM OSM ENSUAMP00000007896 ENSUAMP00000007896 IL34 IL34 EMILIN1 EMILIN1 FGF10 FGF10 SWAP70 SWAP70 ENSUAMP00000008826 ENSUAMP00000008826 HABP2 HABP2 SCARF2 SCARF2 ENSUAMP00000009368 ENSUAMP00000009368 MET MET PRKD1 PRKD1 PTGER4 PTGER4 PYCARD PYCARD NPY NPY TRIM56 TRIM56 PUM2 PUM2 NFKBIZ NFKBIZ PRKCA PRKCA CADM1 CADM1 ENSUAMP00000011509 ENSUAMP00000011509 ENSUAMP00000011673 ENSUAMP00000011673 TXK TXK CARD9 CARD9 COCH COCH NCKAP1L NCKAP1L ENSUAMP00000012035 ENSUAMP00000012035 CD160 CD160 C2CD4C C2CD4C STX3 STX3 FABP4 FABP4 ENSUAMP00000012376 ENSUAMP00000012376 PLA2G3 PLA2G3 TGFB1 TGFB1 NUPR1 NUPR1 F7 F7 ANO6 ANO6 ENSUAMP00000013073 ENSUAMP00000013073 ENSUAMP00000013274 ENSUAMP00000013274 MEGF8 MEGF8 MAPK1 MAPK1 ACOD1 ACOD1 CCR1 CCR1 STAP1 STAP1 STAT5A STAT5A IDO1 IDO1 ENSUAMP00000014099 ENSUAMP00000014099 HSPB1 HSPB1 VEGFC VEGFC PLA2G5 PLA2G5 CAMK2N1 CAMK2N1 ENSUAMP00000015168 ENSUAMP00000015168 PSPC1 PSPC1 RIPOR2 RIPOR2 AIF1 AIF1 NCR3 NCR3 TNF TNF LTA LTA ENSUAMP00000015739 ENSUAMP00000015739 PARK7 PARK7 TNFSF4 TNFSF4 EREG EREG IFI35 IFI35 USP15 USP15 ENSUAMP00000016646 ENSUAMP00000016646 PGF PGF CXCL14 CXCL14 ENSUAMP00000017283 ENSUAMP00000017283 CXCL12 CXCL12 STK26 STK26 GPR68 GPR68 XRCC6 XRCC6 DEF6 DEF6 DNM1L DNM1L TBK1 TBK1 FEM1A FEM1A TMEM102 TMEM102 RBM14 RBM14 ETS1 ETS1 RNF185 RNF185 VEGFB VEGFB TRIM62 TRIM62 TLR3 TLR3 RIPK1 RIPK1 LDLR LDLR SERPINF2 SERPINF2 TRADD TRADD VEGFA VEGFA CCR7 CCR7 ENSUAMP00000020267 ENSUAMP00000020267 GPSM3 GPSM3 CXCL8 CXCL8 AGER AGER ENSUAMP00000020667 ENSUAMP00000020667 MMP8 MMP8 GPR4 GPR4 PRKD2 PRKD2 APOH APOH LSM14A LSM14A THBS1 THBS1 ENSUAMP00000022180 ENSUAMP00000022180 KARS1 KARS1 CCL27 CCL27 CCL19 CCL19 CCL21 CCL21 CCL26 CCL26 NMI NMI KDR KDR RIPK2 RIPK2 ENSUAMP00000023192 ENSUAMP00000023192 PUM1 PUM1 ENSUAMP00000023294 ENSUAMP00000023294 CX3CR1 CX3CR1 ENSUAMP00000023352 ENSUAMP00000023352 NKG7 NKG7 RIOK3 RIOK3 GHSR GHSR IL18 IL18 ANKRD17 ANKRD17 ENSUAMP00000024079 ENSUAMP00000024079 DEFB114 DEFB114 CCN4 CCN4 IL17A IL17A IL17F IL17F BRAF BRAF ENSUAMP00000024788 ENSUAMP00000024788 ENSUAMP00000025106 ENSUAMP00000025106 ENSUAMP00000025300 ENSUAMP00000025300 NLRP1 NLRP1 ENSUAMP00000025368 ENSUAMP00000025368 ENSUAMP00000025370 ENSUAMP00000025370 ZBP1 ZBP1 ZNF580 ZNF580 ENSUAMP00000025608 ENSUAMP00000025608 ENSUAMP00000025678 ENSUAMP00000025678 ENSUAMP00000025782 ENSUAMP00000025782 SUCNR1 SUCNR1 CD180 CD180 AP1G1 AP1G1 LGALS2 LGALS2 LGALS1 LGALS1 PRSS56 PRSS56 TYROBP TYROBP PTN PTN ENSUAMP00000026919 ENSUAMP00000026919 CEBPB CEBPB EMILIN2 EMILIN2 AKIRIN2 AKIRIN2 CD47 CD47 FADD FADD GAS6 GAS6 CD28 CD28 CCDC142 CCDC142 POLR3C POLR3C CRTAM CRTAM KLK7 KLK7 IRF7 IRF7 CCR6 CCR6 CSF1 CSF1 CXCR3 CXCR3 ENSUAMP00000029199 ENSUAMP00000029199 TNFRSF1A TNFRSF1A CXorf21 CXorf21 ENSUAMP00000029322 ENSUAMP00000029322 C3AR1 C3AR1 IL21 IL21 PARP9 PARP9 SIN3A SIN3A IKBKE IKBKE SLIT2 SLIT2 MOSPD2 MOSPD2 TNFSF14 TNFSF14 THBS4 THBS4 TRAF6 TRAF6 ENSUAMP00000030361 ENSUAMP00000030361 ZCCHC3 ZCCHC3 NFKBIA NFKBIA NECTIN2 NECTIN2 DEFB124 DEFB124 VEGFD VEGFD FGF18 FGF18 MSTN MSTN RAC2 RAC2 CMKLR1 CMKLR1 ENSUAMP00000031321 ENSUAMP00000031321 HEXIM1 HEXIM1 STAT5B STAT5B CD81 CD81 ENSUAMP00000031486 ENSUAMP00000031486 VAV1 VAV1 POLR3F POLR3F MAPK3 MAPK3 POLR3B POLR3B ENSUAMP00000031718 ENSUAMP00000031718 SH2D1A SH2D1A SYK SYK DHX58 DHX58 RASGRP1 RASGRP1 CASP6 CASP6 CSF1R CSF1R GHRL GHRL CXCL10 CXCL10 NTRK3 NTRK3 PDCD4 PDCD4 HPX HPX TOMM70 TOMM70 TLR4 TLR4 CD74 CD74 CNTF CNTF FKBP1B FKBP1B ENSUAMP00000033376 ENSUAMP00000033376 IL16 IL16 ENSUAMP00000033501 ENSUAMP00000033501 ZNFX1 ZNFX1 ENSUAMP00000033580 ENSUAMP00000033580 MED1 MED1 IL23A IL23A CXCL13 CXCL13 MNDA MNDA ENSUAMP00000035084 ENSUAMP00000035084 STING1 STING1 SFPQ SFPQ POLR3D POLR3D CREB3 CREB3 MAVS MAVS LGMN LGMN C5AR1 C5AR1 VAMP8 VAMP8 TREM2 TREM2 TREML1 TREML1 VAMP7 VAMP7 TRPV4 TRPV4 PDE2A PDE2A BMPR2 BMPR2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (441 aa)
ENSUAMP00000000033Matrin-type domain-containing protein. (169 aa)
ENSUAMP00000000062Uncharacterized protein. (740 aa)
LY86Lymphocyte antigen 86. (158 aa)
IL18RAPInterleukin 18 receptor accessory protein. (573 aa)
ENSUAMP00000000518Uncharacterized protein. (334 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (874 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (265 aa)
CCR2C-C motif chemokine receptor 2; Belongs to the G-protein coupled receptor 1 family. (373 aa)
FGF16Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (198 aa)
ENSUAMP00000000885Uncharacterized protein. (67 aa)
ENSUAMP00000001223FERM_N_2 domain-containing protein. (102 aa)
ENSUAMP00000001501Uncharacterized protein. (470 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
CD226CD226 molecule. (336 aa)
IL33Interleukin 33. (263 aa)
ENSUAMP00000002230SAM domain-containing protein. (140 aa)
SASH1SAM and SH3 domain containing 1. (764 aa)
FLNAFilamin A. (1660 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (828 aa)
S100A8Protein S100; Belongs to the S-100 family. (136 aa)
S100A14S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
ENSUAMP00000003947Protein S100; Belongs to the S-100 family. (130 aa)
XRCC5X-ray repair cross complementing 5. (501 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (690 aa)
SETD4SET domain containing 4. (355 aa)
SCG2Secretogranin II. (618 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (969 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (241 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
FCN1Ficolin 1. (263 aa)
UBE2KUbiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (205 aa)
TIRAPTIR domain containing adaptor protein. (224 aa)
ENSUAMP00000006398annotation not available (356 aa)
ABCC1ATP binding cassette subfamily C member 1. (1415 aa)
ENSUAMP00000006607Uncharacterized protein. (215 aa)
OXSR1Oxidative stress responsive kinase 1. (529 aa)
P2RX4P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (401 aa)
CDH13Cadherin 13. (495 aa)
TTBK1Tau tubulin kinase 1. (1288 aa)
CGASCyclic GMP-AMP synthase. (406 aa)
APPAmyloid beta precursor protein. (735 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
ENSUAMP00000007290Uncharacterized protein. (172 aa)
ENSUAMP00000007291SEFIR domain-containing protein. (585 aa)
MCUMitochondrial calcium uniporter. (343 aa)
LAMP1Lysosomal associated membrane protein 1. (414 aa)
PLCG21-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1252 aa)
ENSUAMP00000007852Uncharacterized protein. (170 aa)
OSMOncostatin M. (220 aa)
ENSUAMP00000007896Disintegrin domain-containing protein. (332 aa)
IL34Interleukin 34. (236 aa)
EMILIN1Elastin microfibril interfacer 1. (1020 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
SWAP70Switching B cell complex subunit SWAP70. (527 aa)
ENSUAMP00000008826IRF tryptophan pentad repeat domain-containing protein. (421 aa)
HABP2Hyaluronan binding protein 2. (556 aa)
SCARF2Scavenger receptor class F member 2. (746 aa)
ENSUAMP00000009368Uncharacterized protein. (406 aa)
METMET proto-oncogene, receptor tyrosine kinase. (1399 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (848 aa)
PTGER4Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (489 aa)
PYCARDPYD and CARD domain containing. (194 aa)
NPYNeuropeptide Y. (90 aa)
TRIM56Tripartite motif containing 56. (771 aa)
PUM2Pumilio RNA binding family member 2. (851 aa)
NFKBIZNFKB inhibitor zeta. (721 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
CADM1Cell adhesion molecule 1. (339 aa)
ENSUAMP00000011509Ig-like domain-containing protein. (352 aa)
ENSUAMP00000011673EF-hand domain-containing protein; Belongs to the S-100 family. (87 aa)
TXKTyrosine-protein kinase. (527 aa)
CARD9Caspase recruitment domain family member 9. (566 aa)
COCHCochlin. (551 aa)
NCKAP1LNCK associated protein 1 like. (1115 aa)
ENSUAMP00000012035C-C motif chemokine. (93 aa)
CD160CD160 molecule. (186 aa)
C2CD4CC2 calcium dependent domain containing 4C. (420 aa)
STX3Syntaxin 3; Belongs to the syntaxin family. (289 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (126 aa)
ENSUAMP00000012376Uncharacterized protein. (254 aa)
PLA2G3Phospholipase A2 group III. (508 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
F7Coagulation factor VII. (446 aa)
ANO6Anoctamin. (924 aa)
ENSUAMP00000013073Uncharacterized protein. (325 aa)
ENSUAMP00000013274Uncharacterized protein. (176 aa)
MEGF8Multiple EGF like domains 8. (2820 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ACOD1Aconitate decarboxylase 1. (494 aa)
CCR1C-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (355 aa)
STAP1Signal transducing adaptor family member 1. (292 aa)
STAT5ASignal transducer and activator of transcription. (797 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (386 aa)
ENSUAMP00000014099ZP domain-containing protein. (417 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
PLA2G5Phospholipase A(2). (137 aa)
CAMK2N1Calcium/calmodulin dependent protein kinase II inhibitor 1. (78 aa)
ENSUAMP00000015168Uncharacterized protein. (119 aa)
PSPC1Paraspeckle component 1. (349 aa)
RIPOR2PL48 domain-containing protein. (1063 aa)
AIF1Allograft inflammatory factor 1. (147 aa)
NCR3Natural cytotoxicity triggering receptor 3. (211 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
LTALymphotoxin alpha; Belongs to the tumor necrosis factor family. (204 aa)
ENSUAMP00000015739Uncharacterized protein. (122 aa)
PARK7Parkinsonism associated deglycase. (189 aa)
TNFSF4TNF superfamily member 4; Belongs to the tumor necrosis factor family. (183 aa)
EREGEpiregulin. (175 aa)
IFI35Interferon induced protein 35. (309 aa)
USP15Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (968 aa)
ENSUAMP00000016646Uncharacterized protein. (167 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
CXCL14C-X-C motif chemokine ligand 14. (98 aa)
ENSUAMP00000017283Uncharacterized protein. (60 aa)
CXCL12SCY domain-containing protein; Belongs to the intercrine alpha (chemokine CxC) family. (109 aa)
STK26Serine/threonine kinase 26. (416 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (360 aa)
XRCC6X-ray repair cross complementing 6. (527 aa)
DEF6DEF6 guanine nucleotide exchange factor. (631 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (736 aa)
TBK1TANK binding kinase 1. (709 aa)
FEM1AFem-1 homolog A. (661 aa)
TMEM102Transmembrane protein 102. (510 aa)
RBM14RNA binding motif protein 14. (618 aa)
ETS1ETS proto-oncogene 1, transcription factor. (531 aa)
RNF185Ring finger protein 185. (192 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (191 aa)
TRIM62Tripartite motif containing 62. (471 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
LDLRLow density lipoprotein receptor. (856 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (373 aa)
ENSUAMP00000020267Uncharacterized protein. (164 aa)
GPSM3G protein signaling modulator 3. (157 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
AGERAdvanced glycosylation end-product specific receptor. (410 aa)
ENSUAMP00000020667OSR1_C domain-containing protein. (287 aa)
MMP8Matrix metallopeptidase 8. (477 aa)
GPR4G protein-coupled receptor 4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (840 aa)
APOHApolipoprotein H. (345 aa)
LSM14ALSM14A mRNA processing body assembly factor. (481 aa)
THBS1Thrombospondin 1. (1170 aa)
ENSUAMP00000022180PX domain-containing protein. (349 aa)
KARS1Lysine--tRNA ligase. (625 aa)
CCL27C-C motif chemokine ligand 27. (133 aa)
CCL19C-C motif chemokine. (100 aa)
CCL21C-C motif chemokine ligand 21. (138 aa)
CCL26C-C motif chemokine. (92 aa)
NMIN-myc and STAT interactor. (315 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (536 aa)
ENSUAMP00000023192Uncharacterized protein. (192 aa)
PUM1PUM-HD domain-containing protein. (1082 aa)
ENSUAMP00000023294Uncharacterized protein. (67 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
ENSUAMP00000023352Uncharacterized protein. (251 aa)
NKG7Natural killer cell granule protein 7. (165 aa)
RIOK3Serine/threonine-protein kinase RIO3; Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. (519 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
IL18Interleukin 18. (167 aa)
ANKRD17Ankyrin repeat domain 17. (2498 aa)
ENSUAMP00000024079Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
CCN4Cellular communication network factor 4. (361 aa)
IL17AInterleukin 17A. (161 aa)
IL17FInterleukin 17F. (156 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
ENSUAMP00000024788Protein kinase domain-containing protein. (102 aa)
ENSUAMP00000025106Uncharacterized protein. (78 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
NLRP1NLR family pyrin domain containing 1. (1427 aa)
ENSUAMP00000025368TNFR-Cys domain-containing protein. (263 aa)
ENSUAMP00000025370Uncharacterized protein. (358 aa)
ZBP1Z-DNA binding protein 1. (445 aa)
ZNF580Zinc finger protein 580. (199 aa)
ENSUAMP00000025608IRF-3 domain-containing protein. (295 aa)
ENSUAMP00000025678Uncharacterized protein. (163 aa)
ENSUAMP00000025782Uncharacterized protein. (257 aa)
SUCNR1Succinate receptor 1; Belongs to the G-protein coupled receptor 1 family. (318 aa)
CD180CD180 molecule. (632 aa)
AP1G1AP-1 complex subunit gamma. (822 aa)
LGALS2Galectin. (132 aa)
LGALS1Galectin. (138 aa)
PRSS56Serine protease 56; Belongs to the peptidase S1 family. (606 aa)
TYROBPTYRO protein tyrosine kinase binding protein. (129 aa)
PTNPleiotrophin. (218 aa)
ENSUAMP00000026919TIR domain-containing protein. (1033 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
EMILIN2Elastin microfibril interfacer 2. (1075 aa)
AKIRIN2Akirin 2. (203 aa)
CD47CD47 molecule. (320 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
GAS6Growth arrest specific 6. (655 aa)
CD28CD28 molecule. (216 aa)
CCDC142Coiled-coil domain containing 142. (747 aa)
POLR3CRNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (534 aa)
CRTAMCytotoxic and regulatory T cell molecule. (360 aa)
KLK7Kallikrein related peptidase 7; Belongs to the peptidase S1 family. (252 aa)
IRF7Interferon regulatory factor 7. (470 aa)
CCR6C-C motif chemokine receptor 6; Belongs to the G-protein coupled receptor 1 family. (381 aa)
CSF1Colony stimulating factor 1. (518 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (369 aa)
ENSUAMP00000029199Uncharacterized protein. (351 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
CXorf21Chromosome X open reading frame 21. (297 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (336 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (153 aa)
PARP9Poly(ADP-ribose) polymerase family member 9. (827 aa)
SIN3ASIN3 transcription regulator family member A. (1275 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (693 aa)
SLIT2Slit guidance ligand 2. (1450 aa)
MOSPD2Motile sperm domain containing 2. (518 aa)
TNFSF14TNF superfamily member 14; Belongs to the tumor necrosis factor family. (238 aa)
THBS4Thrombospondin 4. (944 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
ENSUAMP00000030361Uncharacterized protein. (285 aa)
ZCCHC3Zinc finger CCHC-type containing 3. (399 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
NECTIN2Nectin cell adhesion molecule 2. (542 aa)
DEFB124Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (68 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (329 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
MSTNMyostatin. (376 aa)
RAC2Rac family small GTPase 2. (192 aa)
CMKLR1Chemerin chemokine-like receptor 1; Belongs to the G-protein coupled receptor 1 family. (364 aa)
ENSUAMP00000031321Uncharacterized protein. (1080 aa)
HEXIM1HEXIM P-TEFb complex subunit 1. (247 aa)
STAT5BSignal transducer and activator of transcription. (784 aa)
CD81Tetraspanin. (392 aa)
ENSUAMP00000031486Calponin-homology (CH) domain-containing protein. (86 aa)
VAV1Vav guanine nucleotide exchange factor 1. (774 aa)
POLR3FRNA polymerase III subunit F. (166 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
POLR3BDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (687 aa)
ENSUAMP00000031718SCY domain-containing protein. (112 aa)
SH2D1ASH2 domain-containing protein 1A; Cytoplasmic adapter regulating receptors of the signaling lymphocytic activation molecule (SLAM) family such as SLAMF1, CD244, LY9, CD84, SLAMF6 and SLAMF7. In SLAM signaling seems to cooperate with SH2D1B/EAT-2. (128 aa)
SYKSpleen associated tyrosine kinase. (638 aa)
DHX58DExH-box helicase 58. (674 aa)
RASGRP1RAS guanyl releasing protein 1. (858 aa)
CASP6Caspase 6; Belongs to the peptidase C14A family. (293 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (967 aa)
GHRLGhrelin and obestatin prepropeptide. (134 aa)
CXCL10C-X-C motif chemokine. (98 aa)
NTRK3Tyrosine-protein kinase receptor. (784 aa)
PDCD4Programmed cell death 4. (474 aa)
HPXHemopexin. (464 aa)
TOMM70Translocase of outer mitochondrial membrane 70. (609 aa)
TLR4Toll like receptor 4; Belongs to the Toll-like receptor family. (833 aa)
CD74CD74 molecule. (279 aa)
CNTFCiliary neurotrophic factor. (200 aa)
FKBP1BPeptidylprolyl isomerase. (108 aa)
ENSUAMP00000033376Uncharacterized protein. (481 aa)
IL16Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. (629 aa)
ENSUAMP00000033501Ig-like domain-containing protein. (339 aa)
ZNFX1Zinc finger NFX1-type containing 1. (1927 aa)
ENSUAMP00000033580Uncharacterized protein. (83 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
IL23AInterleukin 23 subunit alpha. (190 aa)
CXCL13C-X-C motif chemokine ligand 13. (110 aa)
MNDAMyeloid cell nuclear differentiation antigen. (436 aa)
ENSUAMP00000035084Uncharacterized protein. (399 aa)
STING1Transmembrane protein 173. (392 aa)
SFPQSplicing factor proline and glutamine rich. (406 aa)
POLR3DRNA polymerase III subunit D. (367 aa)
CREB3cAMP responsive element binding protein 3. (352 aa)
MAVSMitochondrial antiviral signaling protein. (523 aa)
LGMNLegumain. (433 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
VAMP8Vesicle associated membrane protein 8. (101 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (311 aa)
VAMP7Vesicle associated membrane protein 7; Belongs to the synaptobrevin family. (220 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (861 aa)
PDE2APhosphodiesterase. (975 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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