53 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	TMEM161A	Transmembrane protein 161A. (421 aa)
	NDUFA13	NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
	YJEFN3	YjeF N-terminal domain-containing protein. (250 aa)
	TIE1	Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1069 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	BRINP2	BMP/retinoic acid inducible neural specific 2. (770 aa)
	DNAAF2	Protein kintoun; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. (829 aa)
	PTK2B	Protein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (969 aa)
	ENSUAMP00000004964	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (1696 aa)
	ENSUAMP00000005111	Aldedh domain-containing protein. (208 aa)
	SETX	Senataxin. (2692 aa)
	ABL2	Tyrosine-protein kinase. (1127 aa)
	ENSUAMP00000008823	TAN domain-containing protein. (111 aa)
	TEAD2	TEA domain transcription factor 2. (447 aa)
	ASCL1	Achaete-scute family bHLH transcription factor 1. (213 aa)
	ENSUAMP00000011151	Uncharacterized protein. (596 aa)
	ENSUAMP00000011462	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
	GSK3B	Glycogen synthase kinase 3 beta. (335 aa)
	ENSUAMP00000013328	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
	ENSUAMP00000014216	Homeobox domain-containing protein. (315 aa)
	BRINP1	BMP/retinoic acid inducible neural specific 1. (724 aa)
	ENSUAMP00000017792	Uncharacterized protein. (558 aa)
	HOXA2	Homeobox A2. (374 aa)
	PTK7	Protein tyrosine kinase 7 (inactive); Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
	ENSUAMP00000023399	Uncharacterized protein. (352 aa)
	CDKN2D	Cyclin dependent kinase inhibitor 2D. (166 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	WNT8A	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
	ENSUAMP00000025477	Uncharacterized protein. (185 aa)
	SOX9	SRY-box transcription factor 9. (484 aa)
	STRA8	Stimulated by retinoic acid 8. (372 aa)
	RXRA	Retinoid X receptor alpha. (469 aa)
	TWF2	Twinfilin actin binding protein 2. (349 aa)
	CTSH	Cathepsin H; Belongs to the peptidase C1 family. (372 aa)
	ACER2	Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (275 aa)
	ENSUAMP00000027844	Nuc_recep-AF1 domain-containing protein. (202 aa)
	ENSUAMP00000027845	Uncharacterized protein. (347 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	GDAP1	Ganglioside induced differentiation associated protein 1; Belongs to the GST superfamily. (358 aa)
	BHMG1	Basic helix-loop-helix and HMG-box containing 1. (565 aa)
	SNW1	SNW domain containing 1. (511 aa)
	GDAP2	Ganglioside induced differentiation associated protein 2. (495 aa)
	ENSUAMP00000030480	HARE-HTH domain-containing protein. (88 aa)
	ASXL1	ASXL transcriptional regulator 1. (1306 aa)
	RXRB	Retinoid X receptor beta. (532 aa)
	RET	Proto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1121 aa)
	OVCA2	OVCA2 serine hydrolase domain containing. (227 aa)
	HSD17B2	Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (380 aa)
	AQP3	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family. (292 aa)
	ADNP2	ADNP homeobox 2. (1141 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL2	ENSUAMP00000004964	ENSUAMP00000005699	ENSUAMP00000004964	Tyrosine-protein kinase.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.685
ABL2	ENSUAMP00000008823	ENSUAMP00000005699	ENSUAMP00000008823	Tyrosine-protein kinase.	TAN domain-containing protein.	0.685
ABL2	ENSUAMP00000025477	ENSUAMP00000005699	ENSUAMP00000025477	Tyrosine-protein kinase.	Uncharacterized protein.	0.539
AQP3	ENSUAMP00000011462	ENSUAMP00000033671	ENSUAMP00000011462	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.555
ASCL1	CREB1	ENSUAMP00000010094	ENSUAMP00000024031	Achaete-scute family bHLH transcription factor 1.	cAMP responsive element binding protein 1.	0.594
ASCL1	SOX9	ENSUAMP00000010094	ENSUAMP00000026554	Achaete-scute family bHLH transcription factor 1.	SRY-box transcription factor 9.	0.625
CREB1	ASCL1	ENSUAMP00000024031	ENSUAMP00000010094	cAMP responsive element binding protein 1.	Achaete-scute family bHLH transcription factor 1.	0.594
CREB1	GSK3B	ENSUAMP00000024031	ENSUAMP00000012083	cAMP responsive element binding protein 1.	Glycogen synthase kinase 3 beta.	0.982
CYP26B1	ENSUAMP00000005111	ENSUAMP00000034125	ENSUAMP00000005111	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Aldedh domain-containing protein.	0.905
CYP26B1	ENSUAMP00000013328	ENSUAMP00000034125	ENSUAMP00000013328	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.905
CYP26B1	RARG	ENSUAMP00000034125	ENSUAMP00000003570	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Retinoic acid receptor gamma.	0.438
CYP26B1	SOX9	ENSUAMP00000034125	ENSUAMP00000026554	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	SRY-box transcription factor 9.	0.459
CYP26B1	STRA8	ENSUAMP00000034125	ENSUAMP00000036738	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Stimulated by retinoic acid 8.	0.633
ENSUAMP00000004964	ABL2	ENSUAMP00000004964	ENSUAMP00000005699	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	Tyrosine-protein kinase.	0.685
ENSUAMP00000004964	ENSUAMP00000008823	ENSUAMP00000004964	ENSUAMP00000008823	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	TAN domain-containing protein.	0.899
ENSUAMP00000005111	CYP26B1	ENSUAMP00000005111	ENSUAMP00000034125	Aldedh domain-containing protein.	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.905
ENSUAMP00000005111	ENSUAMP00000013328	ENSUAMP00000005111	ENSUAMP00000013328	Aldedh domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.939
ENSUAMP00000008823	ABL2	ENSUAMP00000008823	ENSUAMP00000005699	TAN domain-containing protein.	Tyrosine-protein kinase.	0.685
ENSUAMP00000008823	ENSUAMP00000004964	ENSUAMP00000008823	ENSUAMP00000004964	TAN domain-containing protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.899
ENSUAMP00000011462	AQP3	ENSUAMP00000011462	ENSUAMP00000033671	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family.	Aquaporin 3 (Gill blood group); Belongs to the MIP/aquaporin (TC 1.A.8) family.	0.555