51 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000000161	Uncharacterized protein. (78 aa)
	SFRP1	Secreted frizzled related protein 1. (337 aa)
	ENSUAMP00000006198	TPR_REGION domain-containing protein. (142 aa)
	LATS1	Uncharacterized protein. (1012 aa)
	ENSUAMP00000006938	Uncharacterized protein. (133 aa)
	PAK1	Non-specific serine/threonine protein kinase. (544 aa)
	PAGR1	PAXIP1 associated glutamate rich protein 1. (254 aa)
	FOXH1	Forkhead box H1. (370 aa)
	ENSUAMP00000007696	Fork-head domain-containing protein. (585 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	ZNF366	Zinc finger protein 366. (754 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	PIAS2	Protein inhibitor of activated STAT 2. (620 aa)
	UBA5	Ubiquitin like modifier activating enzyme 5. (432 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2376 aa)
	GHRHR	Growth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (422 aa)
	DDRGK1	DDRGK domain containing 1. (344 aa)
	FOXA1	Forkhead box A1. (472 aa)
	DAB2	DAB adaptor protein 2. (763 aa)
	PRMT2	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (408 aa)
	PARK7	Parkinsonism associated deglycase. (189 aa)
	RNF14	RBR-type E3 ubiquitin transferase. (474 aa)
	KANK2	KN motif and ankyrin repeat domains 2. (886 aa)
	UFSP2	UFM1 specific peptidase 2. (463 aa)
	SRARP	Steroid receptor associated and regulated protein. (174 aa)
	VPS18	VPS18 core subunit of CORVET and HOPS complexes. (973 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (520 aa)
	SIRT1	Sirtuin 1. (618 aa)
	ENSUAMP00000023846	B30.2/SPRY domain-containing protein. (248 aa)
	ENSUAMP00000023848	Uncharacterized protein. (202 aa)
	CRY2	Cryptochrome circadian regulator 2. (604 aa)
	TCF21	Transcription factor 21. (179 aa)
	NCOR1	Nuclear receptor corepressor 1. (2267 aa)
	ENSUAMP00000025261	GPS2_interact domain-containing protein. (204 aa)
	ENSUAMP00000025477	Uncharacterized protein. (185 aa)
	FSHR	Follicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (691 aa)
	CNOT9	CCR4-NOT transcription complex subunit 9. (300 aa)
	UFL1	UFM1 specific ligase 1. (516 aa)
	ZBTB7A	Zinc finger and BTB domain containing 7A. (529 aa)
	NR0B1	Nuclear receptor subfamily 0 group B member 1. (471 aa)
	SRC	Tyrosine-protein kinase. (557 aa)
	DDX5	DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
	NCOR2	Nuclear receptor corepressor 2. (2465 aa)
	EP300	E1A binding protein p300. (2399 aa)
	PHB	Prohibitin. (272 aa)
	SAFB2	Scaffold attachment factor B2. (961 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	CRY1	Cryptochrome circadian regulator 1. (587 aa)
	PHB2	Prohibitin. (297 aa)
	RNF6	Ring finger protein 6. (683 aa)
	ENSUAMP00000037313	JmjC domain-containing protein. (1114 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CNOT1	CNOT2	ENSUAMP00000011304	ENSUAMP00000021339	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 2.	0.998
CNOT1	CNOT9	ENSUAMP00000011304	ENSUAMP00000027391	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 9.	0.999
CNOT2	CNOT1	ENSUAMP00000021339	ENSUAMP00000011304	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 1.	0.998
CNOT2	CNOT9	ENSUAMP00000021339	ENSUAMP00000027391	CCR4-NOT transcription complex subunit 2.	CCR4-NOT transcription complex subunit 9.	0.998
CNOT9	CNOT1	ENSUAMP00000027391	ENSUAMP00000011304	CCR4-NOT transcription complex subunit 9.	CCR4-NOT transcription complex subunit 1.	0.999
CNOT9	CNOT2	ENSUAMP00000027391	ENSUAMP00000021339	CCR4-NOT transcription complex subunit 9.	CCR4-NOT transcription complex subunit 2.	0.998
CRY1	CRY2	ENSUAMP00000034692	ENSUAMP00000023985	Cryptochrome circadian regulator 1.	Cryptochrome circadian regulator 2.	0.996
CRY1	SIRT1	ENSUAMP00000034692	ENSUAMP00000021491	Cryptochrome circadian regulator 1.	Sirtuin 1.	0.402
CRY2	CRY1	ENSUAMP00000023985	ENSUAMP00000034692	Cryptochrome circadian regulator 2.	Cryptochrome circadian regulator 1.	0.996
DAB2	SRC	ENSUAMP00000015183	ENSUAMP00000030149	DAB adaptor protein 2.	Tyrosine-protein kinase.	0.479
DDRGK1	UBA5	ENSUAMP00000012870	ENSUAMP00000010990	DDRGK domain containing 1.	Ubiquitin like modifier activating enzyme 5.	0.622
DDRGK1	UFL1	ENSUAMP00000012870	ENSUAMP00000028964	DDRGK domain containing 1.	UFM1 specific ligase 1.	0.957
DDRGK1	UFSP2	ENSUAMP00000012870	ENSUAMP00000018507	DDRGK domain containing 1.	UFM1 specific peptidase 2.	0.600
DDRGK1	ZNF366	ENSUAMP00000012870	ENSUAMP00000009068	DDRGK domain containing 1.	Zinc finger protein 366.	0.435
DDX5	EP300	ENSUAMP00000030459	ENSUAMP00000031856	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	E1A binding protein p300.	0.692
DDX5	FOXA1	ENSUAMP00000030459	ENSUAMP00000014538	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Forkhead box A1.	0.539
DDX5	PRMT2	ENSUAMP00000030459	ENSUAMP00000015616	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	Protein arginine methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.	0.437
DDX5	UFL1	ENSUAMP00000030459	ENSUAMP00000028964	DEAD-box helicase 5; Belongs to the DEAD box helicase family.	UFM1 specific ligase 1.	0.472
ENSUAMP00000006938	ENSUAMP00000025477	ENSUAMP00000006938	ENSUAMP00000025477	Uncharacterized protein.	Uncharacterized protein.	0.847
ENSUAMP00000006938	LATS1	ENSUAMP00000006938	ENSUAMP00000006932	Uncharacterized protein.	Uncharacterized protein.	0.872