STRINGSTRING
ENSUAMP00000000693 ENSUAMP00000000693 TP53 TP53 TNFSF13B TNFSF13B ANKRD1 ANKRD1 TRAF1 TRAF1 CCL24 CCL24 PLVAP PLVAP TRAF2 TRAF2 NUB1 NUB1 TNFRSF17 TNFRSF17 ENSUAMP00000003994 ENSUAMP00000003994 YTHDC2 YTHDC2 SFRP1 SFRP1 TXNDC17 TXNDC17 SMPD4 SMPD4 BAG4 BAG4 PTK2B PTK2B ENSUAMP00000004918 ENSUAMP00000004918 TRIM32 TRIM32 FCAR FCAR CDIP1 CDIP1 ENSUAMP00000005552 ENSUAMP00000005552 ENSUAMP00000005553 ENSUAMP00000005553 ENSUAMP00000005556 ENSUAMP00000005556 CXCL16 CXCL16 TNFSF11 TNFSF11 CHI3L1 CHI3L1 TNFRSF13C TNFRSF13C ENSUAMP00000007896 ENSUAMP00000007896 MAP4K3 MAP4K3 ENSUAMP00000007969 ENSUAMP00000007969 CASP10 CASP10 CASP8 CASP8 NFE2L2 NFE2L2 ENSUAMP00000008796 ENSUAMP00000008796 ENSUAMP00000008987 ENSUAMP00000008987 ENSUAMP00000010086 ENSUAMP00000010086 PYCARD PYCARD EDA2R EDA2R ENSUAMP00000012032 ENSUAMP00000012032 ENSUAMP00000012035 ENSUAMP00000012035 ENSUAMP00000012037 ENSUAMP00000012037 CCL7 CCL7 CCL8 CCL8 CCL13 CCL13 ENSUAMP00000012122 ENSUAMP00000012122 FOXO3 FOXO3 FOXO3B FOXO3B FABP4 FABP4 ZFP36 ZFP36 ENSUAMP00000012767 ENSUAMP00000012767 EXT1 EXT1 ZFP36L1 ZFP36L1 MAPK1 MAPK1 TNF TNF DHX9 DHX9 TNFSF18 TNFSF18 ENSUAMP00000016510 ENSUAMP00000016510 INPP5K INPP5K ENSUAMP00000017028 ENSUAMP00000017028 GPD1 GPD1 ZC3H12A ZC3H12A ENSUAMP00000018082 ENSUAMP00000018082 SLC2A4 SLC2A4 GSDME GSDME NR1D1 NR1D1 RIPK1 RIPK1 ARHGEF2 ARHGEF2 TRADD TRADD ADIPOQ ADIPOQ SMPD3 SMPD3 CXCL8 CXCL8 IKBKB IKBKB ENDOG ENDOG YBX3 YBX3 HAS2 HAS2 SIRT1 SIRT1 CCL22 CCL22 CX3CL1 CX3CL1 CACTIN CACTIN CCL19 CCL19 CCL21 CCL21 CCL26 CCL26 OCSTAMP OCSTAMP RORA RORA TCL1A TCL1A CIB1 CIB1 ENSUAMP00000025368 ENSUAMP00000025368 ENSUAMP00000025370 ENSUAMP00000025370 TMEM130 TMEM130 GBA GBA RELA RELA ENSUAMP00000026893 ENSUAMP00000026893 ENSUAMP00000027537 ENSUAMP00000027537 TRAF3IP2 TRAF3IP2 ACTN4 ACTN4 RPS3 RPS3 CCL20 CCL20 PIAS3 PIAS3 DAB2IP DAB2IP ENSUAMP00000028527 ENSUAMP00000028527 ENSUAMP00000028532 ENSUAMP00000028532 KRT18 KRT18 GATA3 GATA3 ENSUAMP00000028937 ENSUAMP00000028937 TNFRSF1A TNFRSF1A SPHK1 SPHK1 ENSUAMP00000030070 ENSUAMP00000030070 ADAM9 ADAM9 TRAF6 TRAF6 NFKBIA NFKBIA ENSUAMP00000030603 ENSUAMP00000030603 SMPD1 SMPD1 MAPK3 MAPK3 ZFP36L2 ZFP36L2 ENSUAMP00000031718 ENSUAMP00000031718 NPNT NPNT ENSUAMP00000032511 ENSUAMP00000032511 ERBIN ERBIN CLDN18 CLDN18 PID1 PID1 TNFRSF1B TNFRSF1B ILK ILK TRAF3 TRAF3 STAT1 STAT1 DCSTAMP DCSTAMP CRHBP CRHBP GPER1 GPER1 CARD14 CARD14 MYOD1 MYOD1 ENSUAMP00000036944 ENSUAMP00000036944 CHUK CHUK TANK TANK HYAL2 HYAL2 HYAL1 HYAL1 HYAL3 HYAL3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000000693Uncharacterized protein. (156 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
TRAF1TNF receptor-associated factor. (415 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
PLVAPPlasmalemma vesicle associated protein. (293 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (523 aa)
NUB1Negative regulator of ubiquitin like proteins 1. (630 aa)
TNFRSF17TNF receptor superfamily member 17. (178 aa)
ENSUAMP00000003994Uncharacterized protein. (110 aa)
YTHDC2YTH domain containing 2. (1088 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
TXNDC17Thioredoxin domain containing 17. (123 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (906 aa)
BAG4BCL2 associated athanogene 4. (457 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (969 aa)
ENSUAMP00000004918Homeobox domain-containing protein. (230 aa)
TRIM32Tripartite motif containing 32. (655 aa)
FCARFc fragment of IgA receptor. (268 aa)
CDIP1Cell death inducing p53 target 1. (208 aa)
ENSUAMP00000005552SCY domain-containing protein. (93 aa)
ENSUAMP00000005553SCY domain-containing protein. (118 aa)
ENSUAMP00000005556SCY domain-containing protein. (133 aa)
CXCL16C-X-C motif chemokine ligand 16. (251 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (408 aa)
TNFRSF13CTNF receptor superfamily member 13C. (207 aa)
ENSUAMP00000007896Disintegrin domain-containing protein. (332 aa)
MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (810 aa)
ENSUAMP00000007969Uncharacterized protein. (166 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (481 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (395 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (606 aa)
ENSUAMP00000008796KH type-2 domain-containing protein. (92 aa)
ENSUAMP00000008987Uncharacterized protein. (249 aa)
ENSUAMP00000010086PDZ domain-containing protein. (818 aa)
PYCARDPYD and CARD domain containing. (194 aa)
EDA2REctodysplasin A2 receptor. (277 aa)
ENSUAMP00000012032C-C motif chemokine. (93 aa)
ENSUAMP00000012035C-C motif chemokine. (93 aa)
ENSUAMP00000012037C-C motif chemokine. (92 aa)
CCL7C-C motif chemokine. (99 aa)
CCL8C-C motif chemokine. (99 aa)
CCL13C-C motif chemokine. (98 aa)
ENSUAMP00000012122C-C motif chemokine. (94 aa)
FOXO3Forkhead box O3. (453 aa)
FOXO3BForkhead box O3B. (244 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (126 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
ENSUAMP00000012767C-C motif chemokine. (101 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
DHX9DExH-box helicase 9. (1276 aa)
TNFSF18TNF superfamily member 18. (178 aa)
ENSUAMP00000016510Pep_M12B_propep domain-containing protein. (222 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (452 aa)
ENSUAMP00000017028WAP domain-containing protein. (63 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
GSDMEGasdermin E. (425 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (600 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (550 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1188 aa)
TRADDTNFRSF1A associated via death domain. (314 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (244 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (703 aa)
ENDOGEndonuclease. (269 aa)
YBX3Y-box binding protein 3. (273 aa)
HAS2Hyaluronan synthase 2. (541 aa)
SIRT1Sirtuin 1. (618 aa)
CCL22C-C motif chemokine. (93 aa)
CX3CL1C-X3-C motif chemokine ligand 1. (392 aa)
CACTINCactin, spliceosome C complex subunit. (752 aa)
CCL19C-C motif chemokine. (100 aa)
CCL21C-C motif chemokine ligand 21. (138 aa)
CCL26C-C motif chemokine. (92 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (480 aa)
RORARAR related orphan receptor A. (522 aa)
TCL1AT cell leukemia/lymphoma 1A. (109 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ENSUAMP00000025368TNFR-Cys domain-containing protein. (263 aa)
ENSUAMP00000025370Uncharacterized protein. (358 aa)
TMEM130Transmembrane protein 130. (435 aa)
GBAGlucosylceramidase. (540 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
ENSUAMP00000026893Peptidase M12B domain-containing protein. (540 aa)
ENSUAMP00000027537SEFIR domain-containing protein. (109 aa)
TRAF3IP2TRAF3 interacting protein 2. (455 aa)
ACTN4Actinin alpha 4. (970 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (243 aa)
CCL20C-C motif chemokine. (96 aa)
PIAS3Protein inhibitor of activated STAT 3. (628 aa)
DAB2IPDAB2 interacting protein. (1100 aa)
ENSUAMP00000028527TNFR-Cys domain-containing protein. (403 aa)
ENSUAMP00000028532Uncharacterized protein. (259 aa)
KRT18Keratin 18; Belongs to the intermediate filament family. (443 aa)
GATA3GATA binding protein 3. (444 aa)
ENSUAMP00000028937SCY domain-containing protein. (150 aa)
TNFRSF1ATNF receptor superfamily member 1A. (502 aa)
SPHK1Sphingosine kinase 1. (387 aa)
ENSUAMP00000030070TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (197 aa)
ADAM9ADAM metallopeptidase domain 9. (572 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
NFKBIANFKB inhibitor alpha. (314 aa)
ENSUAMP00000030603COMM domain-containing protein. (178 aa)
SMPD1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (625 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ZFP36L2ZFP36 ring finger protein like 2. (496 aa)
ENSUAMP00000031718SCY domain-containing protein. (112 aa)
NPNTNephronectin. (462 aa)
ENSUAMP00000032511Protein kinase domain-containing protein. (132 aa)
ERBINErbb2 interacting protein. (1392 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
PID1Phosphotyrosine interaction domain containing 1. (203 aa)
TNFRSF1BTNF receptor superfamily member 1B. (460 aa)
ILKIntegrin linked kinase. (503 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
STAT1Signal transducer and activator of transcription. (824 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
CRHBPCorticotropin releasing hormone binding protein. (315 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
CARD14Caspase recruitment domain family member 14. (1007 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
ENSUAMP00000036944Peptidase M12B domain-containing protein. (848 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
TANKTRAF family member associated NFKB activator. (426 aa)
HYAL2Hyaluronidase. (472 aa)
HYAL1Hyaluronidase. (435 aa)
HYAL3Hyaluronidase. (417 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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