20 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000030310	Zinc_ribbon_10 domain-containing protein. (289 aa)
	ALX3	ALX homeobox 3. (341 aa)
	OSR2	Odd-skipped related transciption factor 2. (312 aa)
	TFAP2A	Transcription factor AP-2 alpha. (442 aa)
	NIPBL	Nipped-B protein. (1833 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	RECK	Reversion inducing cysteine rich protein with kazal motifs. (971 aa)
	HOXD9	Homeobox D9. (341 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	MSX1	Msh homeobox 1. (303 aa)
	TBX5	T-box transcription factor 5. (517 aa)
	ENSUAMP00000005111	Aldedh domain-containing protein. (208 aa)
	ALX4	ALX homeobox 4. (408 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	RDH10	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
	ENSUAMP00000013328	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
	RPGRIP1L	RPGRIP1 like. (1207 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	ENSUAMP00000017946	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family. (272 aa)
	HOXA11	Homeobox A11. (313 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000005111	ENSUAMP00000013328	ENSUAMP00000005111	ENSUAMP00000013328	Aldedh domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.939
ENSUAMP00000005111	RDH10	ENSUAMP00000005111	ENSUAMP00000009079	Aldedh domain-containing protein.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.954
ENSUAMP00000013328	ENSUAMP00000005111	ENSUAMP00000013328	ENSUAMP00000005111	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Aldedh domain-containing protein.	0.939
ENSUAMP00000013328	RDH10	ENSUAMP00000013328	ENSUAMP00000009079	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.954
ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000017946	HOXA11	ENSUAMP00000017946	ENSUAMP00000017948	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	Homeobox A11.	0.460
HOXA11	ENSUAMP00000017946	ENSUAMP00000017948	ENSUAMP00000017946	Homeobox A11.	Homeobox protein; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Belongs to the Abd-B homeobox family.	0.460
MSX1	OSR2	ENSUAMP00000000613	ENSUAMP00000026964	Msh homeobox 1.	Odd-skipped related transciption factor 2.	0.494
MSX1	TBX5	ENSUAMP00000000613	ENSUAMP00000002282	Msh homeobox 1.	T-box transcription factor 5.	0.463
MSX1	TFAP2A	ENSUAMP00000000613	ENSUAMP00000024076	Msh homeobox 1.	Transcription factor AP-2 alpha.	0.712
OSR2	MSX1	ENSUAMP00000026964	ENSUAMP00000000613	Odd-skipped related transciption factor 2.	Msh homeobox 1.	0.494
RDH10	ENSUAMP00000005111	ENSUAMP00000009079	ENSUAMP00000005111	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Aldedh domain-containing protein.	0.954
RDH10	ENSUAMP00000013328	ENSUAMP00000009079	ENSUAMP00000013328	Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.954
TBX5	MSX1	ENSUAMP00000002282	ENSUAMP00000000613	T-box transcription factor 5.	Msh homeobox 1.	0.463
TFAP2A	MSX1	ENSUAMP00000024076	ENSUAMP00000000613	Transcription factor AP-2 alpha.	Msh homeobox 1.	0.712