20 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	MSX1	Msh homeobox 1. (303 aa)
	TBX4	T-box transcription factor 4. (529 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	ALX4	ALX homeobox 4. (408 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
	ZBTB16	Zinc finger and BTB domain containing 16. (423 aa)
	RARB	Retinoic acid receptor beta. (336 aa)
	RPGRIP1L	RPGRIP1 like. (1207 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	OSR2	Odd-skipped related transciption factor 2. (312 aa)
	GPC3	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
	PITX1	Homeobox protein. (313 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	ALX3	ALX homeobox 3. (341 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2987 aa)
	MED1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
	NOTCH1	Notch receptor 1. (2547 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BMP4	ENSUAMP00000000600	ENSUAMP00000028868	ENSUAMP00000000600	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	ENSUAMP00000017830	ENSUAMP00000028868	ENSUAMP00000017830	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	FGF4	ENSUAMP00000028868	ENSUAMP00000032522	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.649
BMP4	GPC3	ENSUAMP00000028868	ENSUAMP00000021714	Bone morphogenetic protein 4.	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	0.429
BMP4	MSX1	ENSUAMP00000028868	ENSUAMP00000000613	Bone morphogenetic protein 4.	Msh homeobox 1.	0.628
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426
ENSUAMP00000000600	BMP4	ENSUAMP00000000600	ENSUAMP00000028868	Uncharacterized protein.	Bone morphogenetic protein 4.	0.428
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671
ENSUAMP00000017830	BMP4	ENSUAMP00000017830	ENSUAMP00000028868	Uncharacterized protein.	Bone morphogenetic protein 4.	0.428
ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	Uncharacterized protein.	Uncharacterized protein.	0.671
FGF4	BMP4	ENSUAMP00000032522	ENSUAMP00000028868	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.649
GPC3	BMP4	ENSUAMP00000021714	ENSUAMP00000028868	Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family.	Bone morphogenetic protein 4.	0.429
MED1	RARB	ENSUAMP00000034047	ENSUAMP00000013099	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Retinoic acid receptor beta.	0.731
MED1	RARG	ENSUAMP00000034047	ENSUAMP00000003570	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	Retinoic acid receptor gamma.	0.778
MSX1	BMP4	ENSUAMP00000000613	ENSUAMP00000028868	Msh homeobox 1.	Bone morphogenetic protein 4.	0.628
MSX1	OSR2	ENSUAMP00000000613	ENSUAMP00000026964	Msh homeobox 1.	Odd-skipped related transciption factor 2.	0.494
MSX1	TBX4	ENSUAMP00000000613	ENSUAMP00000001277	Msh homeobox 1.	T-box transcription factor 4.	0.461
NOTCH1	BMP4	ENSUAMP00000034225	ENSUAMP00000028868	Notch receptor 1.	Bone morphogenetic protein 4.	0.426
OSR2	MSX1	ENSUAMP00000026964	ENSUAMP00000000613	Odd-skipped related transciption factor 2.	Msh homeobox 1.	0.494
PITX1	TBX4	ENSUAMP00000022391	ENSUAMP00000001277	Homeobox protein.	T-box transcription factor 4.	0.538