(27 nodes) Monoubiquitinated histone H2A deubiquitination network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000002152	Uncharacterized protein. (107 aa)
	ENY2	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (163 aa)
	USP16	Ubiquitin carboxyl-terminal hydrolase 16; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. (827 aa)
	ENY2-2	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...] (101 aa)
	BAP1	Ubiquitin carboxyl-terminal hydrolase. (678 aa)
	SF3B3	Splicing factor 3b subunit 3. (1217 aa)
	ATXN7L2	Ataxin 7 like 2. (721 aa)
	MYSM1	Myb like, SWIRM and MPN domains 1. (812 aa)
	TAF12	TATA-box binding protein associated factor 12. (161 aa)
	TAF6	TATA-box binding protein associated factor 6. (685 aa)
	SGF29	SAGA complex associated factor 29. (334 aa)
	TADA3	Transcriptional adaptor 3. (432 aa)
	TAF5	TATA-box binding protein associated factor 5. (462 aa)
	ENSUAMP00000015486	BTP domain-containing protein. (270 aa)
	ENSUAMP00000015490	Uncharacterized protein. (199 aa)
	ENSUAMP00000022614	SCA7 domain-containing protein. (757 aa)
	TADA1	Transcriptional adaptor 1. (193 aa)
	ATXN7L1	Ataxin 7 like 1. (940 aa)
	ENSUAMP00000030480	HARE-HTH domain-containing protein. (88 aa)
	ASXL1	ASXL transcriptional regulator 1. (1306 aa)
	ATXN7L3	Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...] (408 aa)
	KAT2A	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
	TAF10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (199 aa)
	TAF6L	TATA-box binding protein associated factor 6 like. (619 aa)
	SF3B5	Splicing factor 3B subunit 5; Belongs to the SF3B5 family. (86 aa)
	ENSUAMP00000037022	Uncharacterized protein. (253 aa)
	ENSUAMP00000037026	Uncharacterized protein. (472 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASXL1	BAP1	ENSUAMP00000030625	ENSUAMP00000007556	ASXL transcriptional regulator 1.	Ubiquitin carboxyl-terminal hydrolase.	0.953
ASXL1	MYSM1	ENSUAMP00000030625	ENSUAMP00000009015	ASXL transcriptional regulator 1.	Myb like, SWIRM and MPN domains 1.	0.409
ATXN7L1	ATXN7L3	ENSUAMP00000030079	ENSUAMP00000030795	Ataxin 7 like 1.	Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...]	0.922
ATXN7L1	ENSUAMP00000002152	ENSUAMP00000030079	ENSUAMP00000002152	Ataxin 7 like 1.	Uncharacterized protein.	0.889
ATXN7L1	ENSUAMP00000015486	ENSUAMP00000030079	ENSUAMP00000015486	Ataxin 7 like 1.	BTP domain-containing protein.	0.534
ATXN7L1	ENSUAMP00000015490	ENSUAMP00000030079	ENSUAMP00000015490	Ataxin 7 like 1.	Uncharacterized protein.	0.534
ATXN7L1	ENY2	ENSUAMP00000030079	ENSUAMP00000002553	Ataxin 7 like 1.	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...]	0.805
ATXN7L1	ENY2-2	ENSUAMP00000030079	ENSUAMP00000005917	Ataxin 7 like 1.	Transcription and mRNA export factor ENY2; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for trans [...]	0.805
ATXN7L1	KAT2A	ENSUAMP00000030079	ENSUAMP00000031802	Ataxin 7 like 1.	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.	0.775
ATXN7L1	SF3B3	ENSUAMP00000030079	ENSUAMP00000007913	Ataxin 7 like 1.	Splicing factor 3b subunit 3.	0.722
ATXN7L1	SF3B5	ENSUAMP00000030079	ENSUAMP00000035987	Ataxin 7 like 1.	Splicing factor 3B subunit 5; Belongs to the SF3B5 family.	0.538
ATXN7L1	SGF29	ENSUAMP00000030079	ENSUAMP00000012565	Ataxin 7 like 1.	SAGA complex associated factor 29.	0.911
ATXN7L1	TADA1	ENSUAMP00000030079	ENSUAMP00000028755	Ataxin 7 like 1.	Transcriptional adaptor 1.	0.599
ATXN7L1	TADA3	ENSUAMP00000030079	ENSUAMP00000014121	Ataxin 7 like 1.	Transcriptional adaptor 3.	0.925
ATXN7L1	TAF10	ENSUAMP00000030079	ENSUAMP00000033814	Ataxin 7 like 1.	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family.	0.930
ATXN7L1	TAF12	ENSUAMP00000030079	ENSUAMP00000010703	Ataxin 7 like 1.	TATA-box binding protein associated factor 12.	0.903
ATXN7L1	TAF5	ENSUAMP00000030079	ENSUAMP00000014189	Ataxin 7 like 1.	TATA-box binding protein associated factor 5.	0.786
ATXN7L1	TAF6	ENSUAMP00000030079	ENSUAMP00000010870	Ataxin 7 like 1.	TATA-box binding protein associated factor 6.	0.886
ATXN7L1	TAF6L	ENSUAMP00000030079	ENSUAMP00000034080	Ataxin 7 like 1.	TATA-box binding protein associated factor 6 like.	0.823
ATXN7L2	ATXN7L3	ENSUAMP00000007959	ENSUAMP00000030795	Ataxin 7 like 2.	Ataxin-7-like protein 3; Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and EN [...]	0.953