Your Input: | |||||
| CASP10 | Caspase 10; Belongs to the peptidase C14A family. (481 aa) | ||||
| NOL3 | Nucleolar protein 3. (222 aa) | ||||
| CASP8 | Caspase 8; Belongs to the peptidase C14A family. (395 aa) | ||||
| FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa) | ||||