37 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TFAP2B	Transcription factor AP-2 beta. (460 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2987 aa)
	ENSUAMP00000033227	Uncharacterized protein. (448 aa)
	FKBP10	Peptidylprolyl isomerase. (491 aa)
	EGR2	Early growth response 2. (471 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	ENSUAMP00000003003	Plexin_cytopl domain-containing protein. (490 aa)
	ENSUAMP00000004725	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
	ENSUAMP00000004728	G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
	TAB1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (504 aa)
	ENSUAMP00000004918	Homeobox domain-containing protein. (230 aa)
	DCTN5	Dynactin subunit 5. (167 aa)
	PRICKLE1	Prickle planar cell polarity protein 1. (832 aa)
	COL3A1	Collagen type III alpha 1 chain. (997 aa)
	FOXH1	Forkhead box H1. (370 aa)
	LOX	Lysyl oxidase. (414 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (927 aa)
	HES1	Hes family bHLH transcription factor 1. (259 aa)
	ENSUAMP00000010093	SUFU_C domain-containing protein. (81 aa)
	PRDM1	PR/SET domain 1. (846 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (582 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
	SRF	Serum response factor. (507 aa)
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	ENSUAMP00000020431	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
	HECTD1	HECT domain E3 ubiquitin protein ligase 1. (2600 aa)
	ENSUAMP00000021593	Uncharacterized protein. (76 aa)
	NGFR	Nerve growth factor receptor. (388 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)
	SMAD6	Mothers against decapentaplegic homolog. (484 aa)
	PKD2	Polycystin 2, transient receptor potential cation channel. (897 aa)
	ENG	Endoglin. (650 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMPR1A	ENSUAMP00000017504	ENSUAMP00000036181	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.583
ACVRL1	ENG	ENSUAMP00000017504	ENSUAMP00000030016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.753
ACVRL1	SMAD6	ENSUAMP00000017504	ENSUAMP00000026564	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.661
BMPR1A	ACVRL1	ENSUAMP00000036181	ENSUAMP00000017504	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.583
BMPR1A	ENG	ENSUAMP00000036181	ENSUAMP00000030016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.403
BMPR1A	SMAD6	ENSUAMP00000036181	ENSUAMP00000026564	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.836
COL3A1	LOX	ENSUAMP00000007445	ENSUAMP00000008148	Collagen type III alpha 1 chain.	Lysyl oxidase.	0.708
DLL4	HES1	ENSUAMP00000021107	ENSUAMP00000009424	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.563
DLL4	JAG1	ENSUAMP00000021107	ENSUAMP00000034607	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.466
ENG	ACVRL1	ENSUAMP00000030016	ENSUAMP00000017504	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.753
ENG	BMPR1A	ENSUAMP00000030016	ENSUAMP00000036181	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.403
ENSUAMP00000020431	JAG1	ENSUAMP00000020431	ENSUAMP00000034607	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.452
ENSUAMP00000033227	LOX	ENSUAMP00000033227	ENSUAMP00000008148	Uncharacterized protein.	Lysyl oxidase.	0.671
EYA1	JAG1	ENSUAMP00000020415	ENSUAMP00000034607	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.452
HES1	DLL4	ENSUAMP00000009424	ENSUAMP00000021107	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.563
HES1	JAG1	ENSUAMP00000009424	ENSUAMP00000034607	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.641
JAG1	DLL4	ENSUAMP00000034607	ENSUAMP00000021107	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.466
JAG1	ENSUAMP00000020431	ENSUAMP00000034607	ENSUAMP00000020431	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.452
JAG1	EYA1	ENSUAMP00000034607	ENSUAMP00000020415	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.452
JAG1	HES1	ENSUAMP00000034607	ENSUAMP00000009424	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.641