18 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EYA1	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	COL3A1	Collagen type III alpha 1 chain. (997 aa)
	FOXH1	Forkhead box H1. (370 aa)
	SEC24B	SEC24 homolog B, COPII coat complex component. (927 aa)
	HES1	Hes family bHLH transcription factor 1. (259 aa)
	NPRL3	NPR3 like, GATOR1 complex subunit. (582 aa)
	ACVRL1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
	SRF	Serum response factor. (507 aa)
	ENSUAMP00000020431	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
	ENG	Endoglin. (650 aa)
	TFAP2B	Transcription factor AP-2 beta. (460 aa)
	FKBP10	Peptidylprolyl isomerase. (491 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2987 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACVRL1	BMPR1A	ENSUAMP00000017504	ENSUAMP00000036181	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.583
ACVRL1	ENG	ENSUAMP00000017504	ENSUAMP00000030016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.753
BMPR1A	ACVRL1	ENSUAMP00000036181	ENSUAMP00000017504	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.583
BMPR1A	ENG	ENSUAMP00000036181	ENSUAMP00000030016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.403
DLL4	HES1	ENSUAMP00000021107	ENSUAMP00000009424	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.563
DLL4	JAG1	ENSUAMP00000021107	ENSUAMP00000034607	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.466
ENG	ACVRL1	ENSUAMP00000030016	ENSUAMP00000017504	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.753
ENG	BMPR1A	ENSUAMP00000030016	ENSUAMP00000036181	Endoglin.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.403
ENSUAMP00000020431	JAG1	ENSUAMP00000020431	ENSUAMP00000034607	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.452
EYA1	JAG1	ENSUAMP00000020415	ENSUAMP00000034607	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.452
HES1	DLL4	ENSUAMP00000009424	ENSUAMP00000021107	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.563
HES1	JAG1	ENSUAMP00000009424	ENSUAMP00000034607	Hes family bHLH transcription factor 1.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.641
JAG1	DLL4	ENSUAMP00000034607	ENSUAMP00000021107	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.466
JAG1	ENSUAMP00000020431	ENSUAMP00000034607	ENSUAMP00000020431	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.452
JAG1	EYA1	ENSUAMP00000034607	ENSUAMP00000020415	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family.	0.452
JAG1	HES1	ENSUAMP00000034607	ENSUAMP00000009424	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes family bHLH transcription factor 1.	0.641