46 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ENSUAMP00000030304	HH_signal domain-containing protein. (146 aa)
	HOXD13	Homeobox D13. (333 aa)
	HOXD12	Homeobox D12. (270 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	IFT52	Intraflagellar transport 52. (467 aa)
	OSR1	Odd-skipped related transcription factor 1. (267 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	ENSUAMP00000036317	Uncharacterized protein. (281 aa)
	LMBR1	Limb development membrane protein 1; Belongs to the LIMR family. (490 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	HOXA11	Homeobox A11. (313 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	WDPCP	WD repeat containing planar cell polarity effector. (679 aa)
	GNA12	G protein subunit alpha 12. (350 aa)
	IFT140	Intraflagellar transport 140. (1319 aa)
	HAND2	Heart and neural crest derivatives expressed 2. (217 aa)
	ALX4	ALX homeobox 4. (408 aa)
	MKS1	MKS transition zone complex subunit 1. (689 aa)
	TMEM107	Transmembrane protein 107. (140 aa)
	CPLANE1	Uncharacterized protein. (2067 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	HOXC11	Homeobox C11. (304 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	MSX1	Msh homeobox 1. (303 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	GLI3	GLI family zinc finger 3. (1413 aa)
	ENSUAMP00000031438	Protein kinase domain-containing protein. (456 aa)
	ENSUAMP00000030452	Uncharacterized protein. (144 aa)
	ENSUAMP00000030450	Uncharacterized protein. (1283 aa)
	ENSUAMP00000030310	Zinc_ribbon_10 domain-containing protein. (289 aa)
	ENSUAMP00000018719	Uncharacterized protein. (538 aa)
	ENSUAMP00000018722	Uncharacterized protein. (423 aa)
	ENSUAMP00000022333	Uncharacterized protein. (210 aa)
	C2CD3	C2 domain containing 3 centriole elongation regulator. (2209 aa)
	LRP5	Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
	INTU	Inturned planar cell polarity protein. (909 aa)
	IMPAD1	Inositol monophosphatase domain containing 1. (360 aa)
	OSR2	Odd-skipped related transciption factor 2. (312 aa)
	TULP3	Tubby-like protein; Belongs to the TUB family. (444 aa)
	ENSUAMP00000027842	Uncharacterized protein. (99 aa)
	ENSUAMP00000027843	Uncharacterized protein. (119 aa)
	LRP4	LDL receptor related protein 4. (1852 aa)
	IHH	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (419 aa)
	FLVCR1	Feline leukemia virus subgroup C cellular receptor 1. (545 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	BCL2L11	BCL2 like 11. (140 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALX4	HAND2	ENSUAMP00000007005	ENSUAMP00000007457	ALX homeobox 4.	Heart and neural crest derivatives expressed 2.	0.479
BMP4	BMPR1A	ENSUAMP00000028868	ENSUAMP00000036181	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	ENSUAMP00000000600	ENSUAMP00000028868	ENSUAMP00000000600	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	ENSUAMP00000017830	ENSUAMP00000028868	ENSUAMP00000017830	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	HAND2	ENSUAMP00000028868	ENSUAMP00000007457	Bone morphogenetic protein 4.	Heart and neural crest derivatives expressed 2.	0.505
BMP4	IHH	ENSUAMP00000028868	ENSUAMP00000028446	Bone morphogenetic protein 4.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.764
BMP4	MSX1	ENSUAMP00000028868	ENSUAMP00000000613	Bone morphogenetic protein 4.	Msh homeobox 1.	0.628
BMP4	NOG	ENSUAMP00000028868	ENSUAMP00000001684	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.996
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426
BMP4	SMAD4	ENSUAMP00000028868	ENSUAMP00000018392	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.888
BMPR1A	BMP4	ENSUAMP00000036181	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR1A	IHH	ENSUAMP00000036181	ENSUAMP00000028446	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Hedgehog protein; Intercellular signal essential for a variety of patterning events during development.	0.543
BMPR1A	MSX1	ENSUAMP00000036181	ENSUAMP00000000613	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Msh homeobox 1.	0.636
BMPR1A	NOG	ENSUAMP00000036181	ENSUAMP00000001684	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.700
BMPR1A	SMAD4	ENSUAMP00000036181	ENSUAMP00000018392	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Mothers against decapentaplegic homolog.	0.847
C2CD3	TULP3	ENSUAMP00000022517	ENSUAMP00000027078	C2 domain containing 3 centriole elongation regulator.	Tubby-like protein; Belongs to the TUB family.	0.572
CPLANE1	ENSUAMP00000018719	ENSUAMP00000003419	ENSUAMP00000018719	Uncharacterized protein.	Uncharacterized protein.	0.868
CPLANE1	ENSUAMP00000018722	ENSUAMP00000003419	ENSUAMP00000018722	Uncharacterized protein.	Uncharacterized protein.	0.879
ENSUAMP00000000600	BMP4	ENSUAMP00000000600	ENSUAMP00000028868	Uncharacterized protein.	Bone morphogenetic protein 4.	0.428
ENSUAMP00000000600	ENSUAMP00000017830	ENSUAMP00000000600	ENSUAMP00000017830	Uncharacterized protein.	Uncharacterized protein.	0.671