STRINGSTRING
HDAC2 HDAC2 MEF2B MEF2B RFXANK RFXANK ENSUAMP00000000115 ENSUAMP00000000115 ENSUAMP00000000300 ENSUAMP00000000300 CAMTA2 CAMTA2 AKAP8L AKAP8L TOP2A TOP2A TP53 TP53 ANKRD1 ANKRD1 TBX2 TBX2 ENSUAMP00000002126 ENSUAMP00000002126 WDTC1 WDTC1 ENSUAMP00000002604 ENSUAMP00000002604 ENSUAMP00000003572 ENSUAMP00000003572 ENSUAMP00000003678 ENSUAMP00000003678 ENSUAMP00000003709 ENSUAMP00000003709 ENSUAMP00000003860 ENSUAMP00000003860 ENSUAMP00000004152 ENSUAMP00000004152 ENSUAMP00000004213 ENSUAMP00000004213 ENSUAMP00000004918 ENSUAMP00000004918 KAT2B KAT2B ENSUAMP00000005532 ENSUAMP00000005532 MIER3 MIER3 ZMYND15 ZMYND15 TFAP4 TFAP4 ENSUAMP00000006699 ENSUAMP00000006699 ENSUAMP00000006851 ENSUAMP00000006851 ENSUAMP00000007257 ENSUAMP00000007257 BRMS1L BRMS1L THAP7 THAP7 GCM1 GCM1 HES1 HES1 MYOCD MYOCD ENSUAMP00000010108 ENSUAMP00000010108 ENSUAMP00000010109 ENSUAMP00000010109 ENSUAMP00000010248 ENSUAMP00000010248 IKZF3 IKZF3 ENSUAMP00000011802 ENSUAMP00000011802 ENSUAMP00000012241 ENSUAMP00000012241 ENSUAMP00000012266 ENSUAMP00000012266 ENSUAMP00000012552 ENSUAMP00000012552 MTA1 MTA1 HDAC6 HDAC6 PRDM1 PRDM1 SP1 SP1 RAD9B RAD9B SIRT2 SIRT2 ENSUAMP00000015602 ENSUAMP00000015602 GMNN GMNN TOP2B TOP2B ENSUAMP00000016331 ENSUAMP00000016331 NACC2 NACC2 MEF2D MEF2D HDAC10 HDAC10 ENSUAMP00000017773 ENSUAMP00000017773 UHRF1BP1 UHRF1BP1 ENSUAMP00000017947 ENSUAMP00000017947 HDAC1 HDAC1 ZBTB7B ZBTB7B NIPBL NIPBL SMYD4 SMYD4 MIER2 MIER2 NRIP1 NRIP1 ENSUAMP00000020910 ENSUAMP00000020910 NUDT21 NUDT21 DHX36 DHX36 SP2 SP2 ENSUAMP00000021972 ENSUAMP00000021972 ENSUAMP00000022273 ENSUAMP00000022273 MTA3 MTA3 YWHAB YWHAB BCL3 BCL3 MEF2A MEF2A ENSUAMP00000023519 ENSUAMP00000023519 ENSUAMP00000023521 ENSUAMP00000023521 DDX20 DDX20 TCF21 TCF21 ANKRA2 ANKRA2 NCOR1 NCOR1 ENSUAMP00000025261 ENSUAMP00000025261 PKN1 PKN1 MIER1 MIER1 RELA RELA CEBPB CEBPB ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 ENSUAMP00000028141 ENSUAMP00000028141 ENSUAMP00000028373 ENSUAMP00000028373 CBX5 CBX5 FOXP3 FOXP3 KCTD21 KCTD21 DACT1 DACT1 ENSUAMP00000029725 ENSUAMP00000029725 TRAF6 TRAF6 NCOR2 NCOR2 NR2C1 NR2C1 KAT2A KAT2A PHB PHB GLI3 GLI3 HIC1 HIC1 MAGEB16 MAGEB16 USF1 USF1 CIR1 CIR1 PHF6 PHF6 ENSUAMP00000034416 ENSUAMP00000034416 HIF1A HIF1A CRY1 CRY1 SFPQ SFPQ BRMS1 BRMS1 ENSUAMP00000035523 ENSUAMP00000035523 ENSUAMP00000035777 ENSUAMP00000035777 MTA2 MTA2 NR2E1 NR2E1 HDAC3 HDAC3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HDAC2Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (446 aa)
MEF2BMyocyte enhancer factor 2B. (373 aa)
RFXANKRegulatory factor X associated ankyrin containing protein. (260 aa)
ENSUAMP00000000115IBB domain-containing protein. (74 aa)
ENSUAMP00000000300Bromo domain-containing protein. (84 aa)
CAMTA2Calmodulin binding transcription activator 2. (1279 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (645 aa)
TOP2ADNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1505 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
TBX2T-box transcription factor 2. (697 aa)
ENSUAMP00000002126zf-RING_14 domain-containing protein. (110 aa)
WDTC1WD and tetratricopeptide repeats 1. (679 aa)
ENSUAMP00000002604CAF1C_H4-bd domain-containing protein. (133 aa)
ENSUAMP00000003572MAGE domain-containing protein. (254 aa)
ENSUAMP00000003678Uncharacterized protein. (542 aa)
ENSUAMP00000003709MAGE domain-containing protein. (345 aa)
ENSUAMP00000003860Uncharacterized protein. (146 aa)
ENSUAMP00000004152Uncharacterized protein. (265 aa)
ENSUAMP00000004213MAGE domain-containing protein. (344 aa)
ENSUAMP00000004918Homeobox domain-containing protein. (230 aa)
KAT2BLysine acetyltransferase 2B. (629 aa)
ENSUAMP00000005532MAGE domain-containing protein. (260 aa)
MIER3MIER family member 3. (498 aa)
ZMYND15Zinc finger MYND-type containing 15. (724 aa)
TFAP4Transcription factor AP-4. (339 aa)
ENSUAMP00000006699Uncharacterized protein. (409 aa)
ENSUAMP00000006851RBR-type E3 ubiquitin transferase. (137 aa)
ENSUAMP00000007257Hist_deacetyl domain-containing protein. (252 aa)
BRMS1LBRMS1 like transcriptional repressor. (323 aa)
THAP7THAP domain containing 7. (313 aa)
GCM1Glial cells missing transcription factor 1. (435 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
MYOCDMyocardin. (870 aa)
ENSUAMP00000010108Uncharacterized protein. (120 aa)
ENSUAMP00000010109annotation not available (120 aa)
ENSUAMP00000010248Uncharacterized protein. (71 aa)
IKZF3IKAROS family zinc finger 3. (491 aa)
ENSUAMP00000011802Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1116 aa)
ENSUAMP00000012241zf-RING_14 domain-containing protein. (109 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
ENSUAMP00000012552Uncharacterized protein. (72 aa)
MTA1Metastasis associated 1. (741 aa)
HDAC6Histone deacetylase 6. (1136 aa)
PRDM1PR/SET domain 1. (846 aa)
SP1Sp1 transcription factor. (780 aa)
RAD9BCell cycle checkpoint control protein; Belongs to the rad9 family. (438 aa)
SIRT2NAD-dependent protein deacetylase; NAD-dependent protein deacetylase. (426 aa)
ENSUAMP00000015602MAGE domain-containing protein. (356 aa)
GMNNGeminin DNA replication inhibitor. (210 aa)
TOP2BDNA topoisomerase 2; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. (1539 aa)
ENSUAMP00000016331Ubiquitin-like domain-containing protein. (153 aa)
NACC2NACC family member 2. (614 aa)
MEF2DMyocyte enhancer factor 2D. (515 aa)
HDAC10Histone deacetylase 10. (668 aa)
ENSUAMP00000017773CAF1C_H4-bd domain-containing protein. (87 aa)
UHRF1BP1UHRF1 binding protein 1. (1357 aa)
ENSUAMP00000017947Uncharacterized protein. (283 aa)
HDAC1Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (507 aa)
NIPBLNipped-B protein. (1833 aa)
SMYD4SET and MYND domain containing 4. (796 aa)
MIER2MIER family member 2. (526 aa)
NRIP1Nuclear receptor interacting protein 1. (1156 aa)
ENSUAMP00000020910IBB domain-containing protein. (279 aa)
NUDT21Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (229 aa)
DHX36DEAH-box helicase 36. (964 aa)
SP2Sp2 transcription factor. (582 aa)
ENSUAMP00000021972Uncharacterized protein. (778 aa)
ENSUAMP00000022273AGC-kinase C-terminal domain-containing protein. (60 aa)
MTA3Metastasis associated 1 family member 3. (589 aa)
YWHABTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta; Belongs to the 14-3-3 family. (244 aa)
BCL3BCL3 transcription coactivator. (424 aa)
MEF2AMyocyte enhancer factor 2A. (466 aa)
ENSUAMP00000023519MAGE domain-containing protein. (348 aa)
ENSUAMP00000023521MAGE domain-containing protein. (298 aa)
DDX20DEAD-box helicase 20. (815 aa)
TCF21Transcription factor 21. (179 aa)
ANKRA2Ankyrin repeat family A member 2. (320 aa)
NCOR1Nuclear receptor corepressor 1. (2267 aa)
ENSUAMP00000025261GPS2_interact domain-containing protein. (204 aa)
PKN1Protein kinase domain-containing protein. (739 aa)
MIER1MIER1 transcriptional regulator. (461 aa)
RELARELA proto-oncogene, NF-kB subunit. (508 aa)
CEBPBCCAAT/enhancer-binding protein. (346 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
ENSUAMP00000028141Uncharacterized protein. (225 aa)
ENSUAMP00000028373Uncharacterized protein. (68 aa)
CBX5Chromobox 5. (191 aa)
FOXP3Forkhead box P3. (427 aa)
KCTD21Potassium channel tetramerization domain containing 21. (260 aa)
DACT1Dishevelled binding antagonist of beta catenin 1. (827 aa)
ENSUAMP00000029725Uncharacterized protein. (1947 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (541 aa)
NCOR2Nuclear receptor corepressor 2. (2465 aa)
NR2C1Nuclear receptor subfamily 2 group C member 1. (631 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
PHBProhibitin. (272 aa)
GLI3GLI family zinc finger 3. (1413 aa)
HIC1HIC ZBTB transcriptional repressor 1. (713 aa)
MAGEB16MAGE family member B16. (259 aa)
USF1Upstream transcription factor 1. (373 aa)
CIR1Corepressor interacting with RBPJ, 1. (415 aa)
PHF6PHD finger protein 6. (365 aa)
ENSUAMP00000034416Non-specific serine/threonine protein kinase. (686 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
SFPQSplicing factor proline and glutamine rich. (406 aa)
BRMS1BRMS1 transcriptional repressor and anoikis regulator. (316 aa)
ENSUAMP00000035523Uncharacterized protein. (225 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
MTA2Metastasis associated 1 family member 2. (668 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
HDAC3Histone deacetylase 3; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (428 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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