STRINGSTRING
CHPF CHPF GGT6 GGT6 CHPF2 CHPF2 MGST2 MGST2 SLC1A2 SLC1A2 MTHFD1 MTHFD1 PDHX PDHX ENSUAMP00000026668 ENSUAMP00000026668 ELOVL5 ELOVL5 ENSUAMP00000024688 ENSUAMP00000024688 ENSUAMP00000012599 ENSUAMP00000012599 GCDH GCDH MTRR MTRR SPRTN SPRTN ACACB ACACB EXT1 EXT1 ENSUAMP00000013400 ENSUAMP00000013400 GGT5 GGT5 ENSUAMP00000013813 ENSUAMP00000013813 ACLY ACLY XYLT2 XYLT2 ENOPH1 ENOPH1 ENSUAMP00000015522 ENSUAMP00000015522 GSS GSS MAT1A MAT1A ENSUAMP00000017052 ENSUAMP00000017052 ENSUAMP00000018915 ENSUAMP00000018915 ENSUAMP00000019169 ENSUAMP00000019169 MRI1 MRI1 ENSUAMP00000020703 ENSUAMP00000020703 ENSUAMP00000022347 ENSUAMP00000022347 ENSUAMP00000022865 ENSUAMP00000022865 GGT7 GGT7 CDO1 CDO1 ADI1 ADI1 CHST7 CHST7 ENSUAMP00000008512 ENSUAMP00000008512 ACAT1 ACAT1 ELOVL4 ELOVL4 MPC2 MPC2 APIP APIP PPCS PPCS CTH CTH GLCE GLCE ENSUAMP00000011199 ENSUAMP00000011199 ENSUAMP00000011307 ENSUAMP00000011307 ENSUAMP00000012071 ENSUAMP00000012071 GCLC GCLC ENSUAMP00000034957 ENSUAMP00000034957 HTD2 HTD2 PDHB PDHB B4GALNT4 B4GALNT4 MTR MTR DLAT DLAT ACSL1 ACSL1 B4GALNT3 B4GALNT3 MTHFR MTHFR ENSUAMP00000036260 ENSUAMP00000036260 MAT2A MAT2A GCLM GCLM ELOVL3 ELOVL3 PDHA2 PDHA2 BHMT2 BHMT2 BHMT BHMT DSE DSE CHST13 CHST13 ENSUAMP00000033799 ENSUAMP00000033799 LIAS LIAS UGDH UGDH MTAP MTAP ENSUAMP00000000674 ENSUAMP00000000674 CHST12 CHST12 ELOVL1 ELOVL1 ENSUAMP00000001063 ENSUAMP00000001063 ELOVL6 ELOVL6 B4GALT4 B4GALT4 ENSUAMP00000003787 ENSUAMP00000003787 CHST11 CHST11 ENSUAMP00000006241 ENSUAMP00000006241 MAT2B MAT2B ENSUAMP00000006430 ENSUAMP00000006430 B3GNT7 B3GNT7 ELOVL7 ELOVL7 MLYCD MLYCD EXT2 EXT2 ENSUAMP00000007578 ENSUAMP00000007578 PDHA1 PDHA1 CSGALNACT2 CSGALNACT2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHPFHexosyltransferase. (775 aa)
GGT6Gamma-glutamyltransferase 6. (497 aa)
CHPF2Hexosyltransferase. (780 aa)
MGST2Microsomal glutathione S-transferase 2. (146 aa)
SLC1A2Amino acid transporter. (565 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (992 aa)
PDHXDihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (501 aa)
ENSUAMP00000026668Uncharacterized protein. (112 aa)
ELOVL5Elongation of very long chain fatty acids protein 5; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involv [...] (299 aa)
ENSUAMP00000024688Uncharacterized protein. (84 aa)
ENSUAMP00000012599Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (573 aa)
GCDHGlutaryl-CoA dehydrogenase. (436 aa)
MTRR5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (723 aa)
SPRTNSprT-like N-terminal domain. (509 aa)
ACACBAcetyl-CoA carboxylase beta. (2045 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
ENSUAMP00000013400Uncharacterized protein. (569 aa)
GGT5Gamma-glutamyltransferase 5. (570 aa)
ENSUAMP00000013813Sulfotransferase; Belongs to the sulfotransferase 1 family. (411 aa)
ACLYATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1101 aa)
XYLT2Xylosyltransferase 2. (865 aa)
ENOPH1Enolase-phosphatase E1; Bifunctional enzyme that catalyzes the enolization of 2,3- diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK- MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). (261 aa)
ENSUAMP00000015522Uncharacterized protein. (666 aa)
GSSGlutathione synthetase. (536 aa)
MAT1AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (396 aa)
ENSUAMP00000017052Hexosyltransferase. (160 aa)
ENSUAMP00000018915AMP-binding domain-containing protein. (730 aa)
ENSUAMP00000019169Uncharacterized protein. (883 aa)
MRI1Methylthioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily. (384 aa)
ENSUAMP00000020703TPK_catalytic domain-containing protein. (251 aa)
ENSUAMP00000022347Sulfotransferase; Belongs to the sulfotransferase 1 family. (393 aa)
ENSUAMP00000022865ACAS_N domain-containing protein. (125 aa)
GGT7Gamma-glutamyltransferase 7. (662 aa)
CDO1Cysteine dioxygenase. (200 aa)
ADI11,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase; Catalyzes the formation of formate and 2-keto-4- methylthiobutyrate (KMTB) from 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene). Also down-regulates cell migration mediated by MMP14. Belongs to the acireductone dioxygenase (ARD) family. (179 aa)
CHST7Sulfotransferase; Belongs to the sulfotransferase 1 family. (551 aa)
ENSUAMP00000008512Biotin carboxylation domain-containing protein. (206 aa)
ACAT1Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. (417 aa)
ELOVL4Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane [...] (314 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (116 aa)
APIPAPAF1 interacting protein. (199 aa)
PPCSPhosphopantothenoylcysteine synthetase. (310 aa)
CTHCystathionine gamma-lyase. (409 aa)
GLCEGlucuronic acid epimerase. (617 aa)
ENSUAMP00000011199Sulfotransferase; Belongs to the sulfotransferase 1 family. (477 aa)
ENSUAMP00000011307Uncharacterized protein. (1315 aa)
ENSUAMP00000012071GST N-terminal domain-containing protein. (193 aa)
GCLCGlutamate-cysteine ligase catalytic subunit. (576 aa)
ENSUAMP00000034957Uncharacterized protein. (149 aa)
HTD2Hydroxyacyl-thioester dehydratase type 2. (168 aa)
PDHBPyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (359 aa)
B4GALNT4Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (1257 aa)
MTRMethionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1178 aa)
DLATAcetyltransferase component of pyruvate dehydrogenase complex; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (647 aa)
ACSL1Acyl-CoA synthetase long chain family member 1. (436 aa)
B4GALNT3Beta-1,4-N-acetylgalactosaminyltransferase; Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'- diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. (921 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (654 aa)
ENSUAMP00000036260Uncharacterized protein. (1033 aa)
MAT2AS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine from methionine and ATP. (395 aa)
GCLMGlutamate-cysteine ligase modifier subunit. (278 aa)
ELOVL3Elongation of very long chain fatty acids protein 3; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precurs [...] (270 aa)
PDHA2Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (391 aa)
BHMT2Betaine--homocysteine S-methyltransferase 2; Involved in the regulation of homocysteine metabolism. (363 aa)
BHMTBetaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. (407 aa)
DSEDermatan sulfate epimerase. (963 aa)
CHST13Carbohydrate sulfotransferase. (318 aa)
ENSUAMP00000033799Uncharacterized protein. (328 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
UGDHUDP-glucose 6-dehydrogenase; Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. (494 aa)
MTAPS-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (255 aa)
ENSUAMP00000000674Uncharacterized protein. (258 aa)
CHST12Carbohydrate sulfotransferase. (419 aa)
ELOVL1Elongation of very long chain fatty acids protein 1; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that [...] (291 aa)
ENSUAMP00000001063Elongation of very long chain fatty acids protein. (96 aa)
ELOVL6Elongation of very long chain fatty acids protein. (181 aa)
B4GALT4Beta-1,4-galactosyltransferase 4. (344 aa)
ENSUAMP00000003787Uncharacterized protein. (209 aa)
CHST11Carbohydrate sulfotransferase. (312 aa)
ENSUAMP00000006241GST N-terminal domain-containing protein. (60 aa)
MAT2BMethionine adenosyltransferase 2 subunit beta; Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. (324 aa)
ENSUAMP00000006430Uncharacterized protein; Belongs to the GST superfamily. (226 aa)
B3GNT7Hexosyltransferase. (398 aa)
ELOVL7Elongation of very long chain fatty acids protein 7; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0 [...] (281 aa)
MLYCDMalonyl-CoA decarboxylase. (500 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (673 aa)
ENSUAMP00000007578ACAS_N domain-containing protein. (194 aa)
PDHA1Pyruvate dehydrogenase E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (390 aa)
CSGALNACT2Hexosyltransferase. (388 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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