STRINGSTRING
ENSUAMP00000013164 ENSUAMP00000013164 ENSUAMP00000013341 ENSUAMP00000013341 ENSUAMP00000013482 ENSUAMP00000013482 CACUL1 CACUL1 CDC16 CDC16 ENSUAMP00000018536 ENSUAMP00000018536 ENSUAMP00000018470 ENSUAMP00000018470 ENSUAMP00000018288 ENSUAMP00000018288 PPP6C PPP6C CKS1B CKS1B ENSUAMP00000017577 ENSUAMP00000017577 ACVR1B ACVR1B NEUROG1 NEUROG1 NES NES IQGAP3 IQGAP3 EIF4E EIF4E RB1 RB1 ENSUAMP00000014770 ENSUAMP00000014770 CCDC57 CCDC57 TPD52L1 TPD52L1 ENSUAMP00000014202 ENSUAMP00000014202 CHEK2 CHEK2 CCNA2 CCNA2 PIM2 PIM2 ENSUAMP00000023965 ENSUAMP00000023965 FBXL12 FBXL12 RPS6KB1 RPS6KB1 MTA3 MTA3 CCNI CCNI SOWAHB SOWAHB SIRT7 SIRT7 CKS2 CKS2 ANAPC1 ANAPC1 E2F4 E2F4 ENSUAMP00000019862 ENSUAMP00000019862 ENSUAMP00000019861 ENSUAMP00000019861 ENSUAMP00000000547 ENSUAMP00000000547 AKAP8L AKAP8L ENSUAMP00000001367 ENSUAMP00000001367 ENSUAMP00000001524 ENSUAMP00000001524 LATS2 LATS2 ENSUAMP00000001886 ENSUAMP00000001886 CCNB1 CCNB1 ENSUAMP00000002455 ENSUAMP00000002455 ENSUAMP00000002462 ENSUAMP00000002462 CCNA1 CCNA1 ENSUAMP00000002888 ENSUAMP00000002888 ENSUAMP00000002920 ENSUAMP00000002920 CHMP2A CHMP2A ENSUAMP00000004606 ENSUAMP00000004606 TIPIN TIPIN ENSUAMP00000005048 ENSUAMP00000005048 ENSUAMP00000006884 ENSUAMP00000006884 LATS1 LATS1 ENSUAMP00000006938 ENSUAMP00000006938 APP APP CHEK1 CHEK1 FBXL6 FBXL6 TFDP1 TFDP1 CDKN1B CDKN1B CCNB2 CCNB2 PPP3CA PPP3CA UPF1 UPF1 CCNE1 CCNE1 NPAT NPAT CDK16 CDK16 ENSUAMP00000037026 ENSUAMP00000037026 ENSUAMP00000037022 ENSUAMP00000037022 RBBP8 RBBP8 ENSUAMP00000036960 ENSUAMP00000036960 ENSUAMP00000036959 ENSUAMP00000036959 CCND3 CCND3 CCNG1 CCNG1 CCNO CCNO WNT10B WNT10B CDC25B CDC25B RPL24 RPL24 TIMELESS TIMELESS E2F3 E2F3 E2F1 E2F1 CCNG2 CCNG2 ENSUAMP00000034037 ENSUAMP00000034037 ENSUAMP00000033960 ENSUAMP00000033960 TAF10 TAF10 KAT14 KAT14 LZTS1 LZTS1 CDK15 CDK15 CCND1 CCND1 MYC MYC ENSUAMP00000031131 ENSUAMP00000031131 TRIM71 TRIM71 CHMP7 CHMP7 CDC25A CDC25A EIF4EBP1 EIF4EBP1 CDK5 CDK5 ENSUAMP00000029036 ENSUAMP00000029036 EZH2 EZH2 KLF11 KLF11 ANAPC2 ANAPC2 FBXL7 FBXL7 ENSUAMP00000027388 ENSUAMP00000027388 AFMID AFMID BIRC5 BIRC5 FOXM1 FOXM1 MAP3K11 MAP3K11 OVOL1 OVOL1 FBXL3 FBXL3 CCNJ CCNJ ENSUAMP00000026406 ENSUAMP00000026406 ENSUAMP00000026405 ENSUAMP00000026405 UBE2S UBE2S SKP2 SKP2 SPDYA SPDYA USH1C USH1C ZPR1 ZPR1 KDM8 KDM8 ENSUAMP00000024660 ENSUAMP00000024660 SPAST SPAST CDK1 CDK1 CCNJL CCNJL PHF8 PHF8 CDK17 CDK17 ANAPC7 ANAPC7 FBXL17 FBXL17 ITGB1 ITGB1 NASP NASP FBXL15 FBXL15 ENSUAMP00000010403 ENSUAMP00000010403 ENSUAMP00000010407 ENSUAMP00000010407 ENSUAMP00000010408 ENSUAMP00000010408 ENSUAMP00000010431 ENSUAMP00000010431 BACH1 BACH1 CDC7 CDC7 RCC1 RCC1 CDC27 CDC27 ENSUAMP00000010748 ENSUAMP00000010748 CTDP1 CTDP1 PPP2R2D PPP2R2D ENSUAMP00000011715 ENSUAMP00000011715 ENSUAMP00000011742 ENSUAMP00000011742 ENSUAMP00000011763 ENSUAMP00000011763 MASTL MASTL ENSUAMP00000012508 ENSUAMP00000012508 UBE2C UBE2C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000013164E2F_TDP domain-containing protein. (75 aa)
ENSUAMP00000013341UCH_N domain-containing protein. (317 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
CACUL1CDK2 associated cullin domain 1; Belongs to the cullin family. (351 aa)
CDC16Cell division cycle 16. (624 aa)
ENSUAMP00000018536Uncharacterized protein; Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. Belongs to the endosulfine family. (121 aa)
ENSUAMP00000018470Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (298 aa)
ENSUAMP00000018288Uncharacterized protein. (273 aa)
PPP6CSerine/threonine-protein phosphatase. (305 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
ENSUAMP00000017577E2F_CC-MB domain-containing protein. (139 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
NEUROG1Neurogenin 1. (251 aa)
NESNestin; Belongs to the intermediate filament family. (1793 aa)
IQGAP3IQ motif containing GTPase activating protein 3. (1630 aa)
EIF4EEukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (180 aa)
RB1RB transcriptional corepressor 1. (870 aa)
ENSUAMP00000014770G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (376 aa)
CCDC57Coiled-coil domain containing 57. (638 aa)
TPD52L1TPD52 like 1. (213 aa)
ENSUAMP00000014202Uncharacterized protein. (81 aa)
CHEK2Checkpoint kinase 2. (530 aa)
CCNA2Cyclin A2; Belongs to the cyclin family. (425 aa)
PIM2Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (311 aa)
ENSUAMP00000023965F-box domain-containing protein. (94 aa)
FBXL12F-box and leucine rich repeat protein 12. (316 aa)
RPS6KB1Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (524 aa)
MTA3Metastasis associated 1 family member 3. (589 aa)
CCNICyclin I. (250 aa)
SOWAHBSosondowah ankyrin repeat domain family member B. (779 aa)
SIRT7Sirtuin 7. (424 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (74 aa)
ANAPC1APC1_C domain-containing protein. (1191 aa)
E2F4E2F transcription factor 4. (406 aa)
ENSUAMP00000019862Uncharacterized protein. (350 aa)
ENSUAMP00000019861F-box domain-containing protein. (51 aa)
ENSUAMP00000000547USP domain-containing protein; Belongs to the peptidase C19 family. (368 aa)
AKAP8LA-kinase anchoring protein 8 like; Belongs to the AKAP95 family. (645 aa)
ENSUAMP00000001367CYCLIN domain-containing protein; Belongs to the cyclin family. (200 aa)
ENSUAMP00000001524Uncharacterized protein. (75 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
ENSUAMP00000001886Uncharacterized protein. (123 aa)
CCNB1Cyclin B1; Belongs to the cyclin family. (425 aa)
ENSUAMP00000002455TPR_REGION domain-containing protein. (149 aa)
ENSUAMP00000002462Uncharacterized protein. (120 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (447 aa)
ENSUAMP00000002888Uncharacterized protein. (295 aa)
ENSUAMP00000002920Uncharacterized protein. (80 aa)
CHMP2ACharged multivesicular body protein 2A. (222 aa)
ENSUAMP00000004606Uncharacterized protein. (1041 aa)
TIPINTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (289 aa)
ENSUAMP00000005048Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (241 aa)
ENSUAMP00000006884Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (289 aa)
LATS1Uncharacterized protein. (1012 aa)
ENSUAMP00000006938Uncharacterized protein. (133 aa)
APPAmyloid beta precursor protein. (735 aa)
CHEK1Checkpoint kinase 1; Belongs to the protein kinase superfamily. (476 aa)
FBXL6F-box and leucine rich repeat protein 6. (533 aa)
TFDP1Transcription factor Dp-1. (477 aa)
CDKN1BCyclin dependent kinase inhibitor 1B. (200 aa)
CCNB2Cyclin B2; Belongs to the cyclin family. (397 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
UPF1UPF1 RNA helicase and ATPase. (1119 aa)
CCNE1Cyclin E1; Belongs to the cyclin family. (370 aa)
NPATNuclear protein, coactivator of histone transcription. (1380 aa)
CDK16Cyclin dependent kinase 16. (540 aa)
ENSUAMP00000037026Uncharacterized protein. (472 aa)
ENSUAMP00000037022Uncharacterized protein. (253 aa)
RBBP8RB binding protein 8, endonuclease. (873 aa)
ENSUAMP00000036960Uncharacterized protein. (136 aa)
ENSUAMP00000036959Uncharacterized protein. (563 aa)
CCND3Cyclin D3; Belongs to the cyclin family. (292 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
CCNOCyclin O; Belongs to the cyclin family. (352 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
CDC25BCell division cycle 25B. (559 aa)
RPL24Ribosomal protein L24. (157 aa)
TIMELESSTimeless circadian regulator. (1207 aa)
E2F3E2F transcription factor 3. (469 aa)
E2F1E2F transcription factor 1. (400 aa)
CCNG2Cyclin G2; Belongs to the cyclin family. (343 aa)
ENSUAMP00000034037SH3 domain-containing protein. (437 aa)
ENSUAMP00000033960Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (58 aa)
TAF10Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (199 aa)
KAT14Lysine acetyltransferase 14. (780 aa)
LZTS1Leucine zipper tumor suppressor 1. (606 aa)
CDK15Cyclin dependent kinase 15. (414 aa)
CCND1Cyclin D1; Belongs to the cyclin family. (294 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (439 aa)
ENSUAMP00000031131Protein kinase domain-containing protein. (264 aa)
TRIM71Tripartite motif containing 71. (858 aa)
CHMP7Charged multivesicular body protein 7. (482 aa)
CDC25ACell division cycle 25A. (498 aa)
EIF4EBP1Eukaryotic translation initiation factor 4E binding protein 1. (118 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ENSUAMP00000029036Uncharacterized protein. (233 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
KLF11Kruppel like factor 11. (413 aa)
ANAPC2Anaphase promoting complex subunit 2; Belongs to the cullin family. (893 aa)
FBXL7F-box and leucine rich repeat protein 7. (457 aa)
ENSUAMP00000027388Uncharacterized protein. (60 aa)
AFMIDKynurenine formamidase; Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites. (285 aa)
BIRC5Baculoviral IAP repeat containing 5. (142 aa)
FOXM1Forkhead box M1. (795 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase 11. (844 aa)
OVOL1Ovo like transcriptional repressor 1. (247 aa)
FBXL3F-box and leucine rich repeat protein 3. (428 aa)
CCNJCyclin J; Belongs to the cyclin family. (383 aa)
ENSUAMP00000026406Protein kinase domain-containing protein. (191 aa)
ENSUAMP00000026405Protein kinase domain-containing protein. (198 aa)
UBE2SUbiquitin conjugating enzyme E2 S; Belongs to the ubiquitin-conjugating enzyme family. (296 aa)
SKP2S-phase kinase associated protein 2. (436 aa)
SPDYASpeedy/RINGO cell cycle regulator family member A. (311 aa)
USH1CUSH1 protein network component harmonin. (859 aa)
ZPR1ZPR1 zinc finger. (460 aa)
KDM8Lysine demethylase 8. (415 aa)
ENSUAMP00000024660Protein kinase domain-containing protein. (224 aa)
SPASTSpastin; ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation [...] (635 aa)
CDK1Cyclin dependent kinase 1. (305 aa)
CCNJLCyclin J like; Belongs to the cyclin family. (447 aa)
PHF8PHD finger protein 8. (1004 aa)
CDK17Cyclin dependent kinase 17. (523 aa)
ANAPC7Anaphase promoting complex subunit 7. (586 aa)
FBXL17F-box and leucine rich repeat protein 17. (662 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
NASPNuclear autoantigenic sperm protein. (669 aa)
FBXL15F-box and leucine rich repeat protein 15. (300 aa)
ENSUAMP00000010403Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (66 aa)
ENSUAMP00000010407PPM-type phosphatase domain-containing protein. (179 aa)
ENSUAMP00000010408PPM-type phosphatase domain-containing protein. (239 aa)
ENSUAMP00000010431Uncharacterized protein. (415 aa)
BACH1BTB domain and CNC homolog 1. (748 aa)
CDC7Cell division cycle 7. (575 aa)
RCC1Regulator of chromosome condensation 1. (432 aa)
CDC27Cell division cycle 27. (729 aa)
ENSUAMP00000010748Uncharacterized protein. (49 aa)
CTDP1RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (937 aa)
PPP2R2DSerine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (449 aa)
ENSUAMP00000011715DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (404 aa)
ENSUAMP00000011742DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (667 aa)
ENSUAMP00000011763DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (295 aa)
MASTLMicrotubule associated serine/threonine kinase like. (881 aa)
ENSUAMP00000012508SMC_N domain-containing protein. (1106 aa)
UBE2CUbiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (176 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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