STRINGSTRING
ENSUAMP00000027842 ENSUAMP00000027842 RAG2 RAG2 ENSUAMP00000027699 ENSUAMP00000027699 SMO SMO STAT6 STAT6 DMRTA2 DMRTA2 NKX6-2 NKX6-2 CTR9 CTR9 TEAD4 TEAD4 SOX8 SOX8 WNT7B WNT7B FOXN1 FOXN1 JAG2 JAG2 VWA5B1 VWA5B1 FOXA1 FOXA1 ENSUAMP00000014216 ENSUAMP00000014216 TBX1 TBX1 PRDM1 PRDM1 EXT1 EXT1 ENSUAMP00000013073 ENSUAMP00000013073 WNT9A WNT9A WNT3A WNT3A PAF1 PAF1 CDON CDON TBX10 TBX10 FOXN4 FOXN4 GATA1 GATA1 TOX TOX TENM4 TENM4 RAB10 RAB10 ENSUAMP00000010818 ENSUAMP00000010818 BARHL2 BARHL2 EPAS1 EPAS1 ENSUAMP00000010461 ENSUAMP00000010461 ENSUAMP00000010249 ENSUAMP00000010249 ASCL1 ASCL1 ENSUAMP00000010093 ENSUAMP00000010093 ITGB1 ITGB1 NODAL NODAL TBX19 TBX19 GSC GSC HES1 HES1 DLX2 DLX2 DLX1 DLX1 GATA4 GATA4 ENSUAMP00000009098 ENSUAMP00000009098 GCM1 GCM1 SPRY2 SPRY2 STAT3 STAT3 FGF10 FGF10 WNT2B WNT2B PTCH1 PTCH1 ENSUAMP00000006938 ENSUAMP00000006938 LATS1 LATS1 ENSUAMP00000006610 ENSUAMP00000006610 ENSUAMP00000006202 ENSUAMP00000006202 DBX1 DBX1 ISL1 ISL1 ENSUAMP00000004728 ENSUAMP00000004728 ENSUAMP00000004725 ENSUAMP00000004725 SFRP1 SFRP1 WNT8B WNT8B ENSUAMP00000002679 ENSUAMP00000002679 WNT11 WNT11 TBX5 TBX5 PROX1 PROX1 SOX12 SOX12 CTSV CTSV VWA5B2 VWA5B2 GATA2 GATA2 LATS2 LATS2 WNT6 WNT6 ENSUAMP00000001477 ENSUAMP00000001477 HOXC10 HOXC10 TBX2 TBX2 TBX4 TBX4 TP53 TP53 ENSUAMP00000000756 ENSUAMP00000000756 ENSUAMP00000000624 ENSUAMP00000000624 ENSUAMP00000000600 ENSUAMP00000000600 ENSUAMP00000000397 ENSUAMP00000000397 ENSUAMP00000000316 ENSUAMP00000000316 ENSUAMP00000000215 ENSUAMP00000000215 POU1F1 POU1F1 APC APC ENSUAMP00000026773 ENSUAMP00000026773 ENSUAMP00000026772 ENSUAMP00000026772 SIX2 SIX2 ENSUAMP00000026652 ENSUAMP00000026652 SOX9 SOX9 WNT4 WNT4 TCF7L2 TCF7L2 TLX3 TLX3 TBR1 TBR1 SPDEF SPDEF TBX20 TBX20 TM2D3 TM2D3 ATOH7 ATOH7 WNT8A WNT8A BRAF BRAF ENSUAMP00000024173 ENSUAMP00000024173 WNT5A WNT5A KDR KDR PTCH2 PTCH2 PITX1 PITX1 ENSUAMP00000022339 ENSUAMP00000022339 ENSUAMP00000022336 ENSUAMP00000022336 OLIG3 OLIG3 SMAD5 SMAD5 IL7 IL7 WNT16 WNT16 TBX22 TBX22 BMP2 BMP2 TBX18 TBX18 DLL4 DLL4 GAP43 GAP43 ENSUAMP00000020431 ENSUAMP00000020431 EYA1 EYA1 KIAA1549 KIAA1549 ARHGEF2 ARHGEF2 MTOR MTOR ATOH1 ATOH1 GSX2 GSX2 LEO1 LEO1 GATA5 GATA5 APC2 APC2 SMAD4 SMAD4 FEV FEV WNT10A WNT10A IL6R IL6R HOXA11 HOXA11 HOXA2 HOXA2 ENSUAMP00000017830 ENSUAMP00000017830 TGFB1I1 TGFB1I1 NEUROG1 NEUROG1 VWA5A VWA5A BATF BATF SOSTDC1 SOSTDC1 LHX3 LHX3 TGFBR1 TGFBR1 DMRT3 DMRT3 ENSUAMP00000016112 ENSUAMP00000016112 MYT1L MYT1L OLIG2 OLIG2 EPOP EPOP MYOD1 MYOD1 EOMES EOMES SOX17 SOX17 NR2E1 NR2E1 WNT9B WNT9B WNT3 WNT3 ZNF521 ZNF521 WNT7A WNT7A PRADC1 PRADC1 WNT10B WNT10B WNT1 WNT1 DHH DHH MYL10 MYL10 PRDM14 PRDM14 NOTCH1 NOTCH1 CYP26B1 CYP26B1 HOXD10 HOXD10 PML PML FEZF2 FEZF2 SOX13 SOX13 NKX2-2 NKX2-2 ISL2 ISL2 GLI3 GLI3 EHMT2 EHMT2 NKX2-1 NKX2-1 TBX6 TBX6 LBX1 LBX1 RTF1 RTF1 ENSUAMP00000031091 ENSUAMP00000031091 MYL2 MYL2 IL6 IL6 EDN1 EDN1 ENSUAMP00000030325 ENSUAMP00000030325 ENSUAMP00000030304 ENSUAMP00000030304 GSX1 GSX1 MITF MITF IRF4 IRF4 MEF2C MEF2C MGA MGA TBXT TBXT DLL1 DLL1 BMP4 BMP4 DOCK7 DOCK7 GATA3 GATA3 IHH IHH ENSUAMP00000027843 ENSUAMP00000027843
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000027842Uncharacterized protein. (99 aa)
RAG2Recombination activating 2. (527 aa)
ENSUAMP00000027699Uncharacterized protein. (214 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
STAT6Signal transducer and activator of transcription. (844 aa)
DMRTA2DMRT like family A2. (514 aa)
NKX6-2NK6 homeobox 2. (269 aa)
CTR9CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa)
TEAD4TEA domain transcription factor 4. (353 aa)
SOX8SRY-box transcription factor 8. (449 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
FOXN1Forkhead box N1. (634 aa)
JAG2Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1197 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1209 aa)
FOXA1Forkhead box A1. (472 aa)
ENSUAMP00000014216Homeobox domain-containing protein. (315 aa)
TBX1T-box transcription factor 1. (464 aa)
PRDM1PR/SET domain 1. (846 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
ENSUAMP00000013073Uncharacterized protein. (325 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
PAF1PAF1 homolog, Paf1/RNA polymerase II complex component. (528 aa)
CDONCell adhesion associated, oncogene regulated. (1021 aa)
TBX10T-box transcription factor 10. (388 aa)
FOXN4Forkhead box N4. (514 aa)
GATA1GATA binding protein 1. (413 aa)
TOXThymocyte selection associated high mobility group box. (526 aa)
TENM4Teneurin transmembrane protein 4. (2640 aa)
RAB10RAB10, member RAS oncogene family. (194 aa)
ENSUAMP00000010818Homeobox domain-containing protein. (263 aa)
BARHL2BarH like homeobox 2. (387 aa)
EPAS1Endothelial PAS domain protein 1. (863 aa)
ENSUAMP00000010461BHLH domain-containing protein. (178 aa)
ENSUAMP00000010249Uncharacterized protein. (106 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (213 aa)
ENSUAMP00000010093SUFU_C domain-containing protein. (81 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
NODALNodal growth differentiation factor. (348 aa)
TBX19T-box transcription factor 19. (444 aa)
GSCGoosecoid homeobox. (256 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
DLX2Distal-less homeobox 2. (333 aa)
DLX1Distal-less homeobox 1. (255 aa)
GATA4GATA binding protein 4. (443 aa)
ENSUAMP00000009098C2H2-type domain-containing protein. (235 aa)
GCM1Glial cells missing transcription factor 1. (435 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
PTCH1Patched 1. (1453 aa)
ENSUAMP00000006938Uncharacterized protein. (133 aa)
LATS1Uncharacterized protein. (1012 aa)
ENSUAMP00000006610CUT domain-containing protein. (259 aa)
ENSUAMP00000006202JmjC domain-containing protein. (934 aa)
DBX1Developing brain homeobox 1. (341 aa)
ISL1ISL LIM homeobox 1. (349 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
ENSUAMP00000002679Uncharacterized protein. (108 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
TBX5T-box transcription factor 5. (517 aa)
PROX1Prospero homeobox 1. (737 aa)
SOX12Transcription factor SOX. (314 aa)
CTSVCathepsin V; Belongs to the peptidase C1 family. (324 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1245 aa)
GATA2GATA binding protein 2. (480 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
ENSUAMP00000001477Uncharacterized protein. (89 aa)
HOXC10Homeobox C10. (342 aa)
TBX2T-box transcription factor 2. (697 aa)
TBX4T-box transcription factor 4. (529 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
ENSUAMP00000000624NGF domain-containing protein; Belongs to the NGF-beta family. (211 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
ENSUAMP00000000215Uncharacterized protein. (131 aa)
POU1F1POU domain protein. (291 aa)
APCAPC regulator of WNT signaling pathway. (2832 aa)
ENSUAMP00000026773Uncharacterized protein. (179 aa)
ENSUAMP00000026772ETS domain-containing protein. (163 aa)
SIX2SIX homeobox 2. (296 aa)
ENSUAMP00000026652HMG box domain-containing protein. (392 aa)
SOX9SRY-box transcription factor 9. (484 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
TLX3T cell leukemia homeobox 3. (291 aa)
TBR1T-box brain transcription factor 1. (682 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
TBX20T-box transcription factor 20. (448 aa)
TM2D3TM2 domain containing 3. (252 aa)
ATOH7Atonal bHLH transcription factor 7. (149 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (728 aa)
ENSUAMP00000024173DUF3398 domain-containing protein. (570 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
PTCH2Patched 2. (1207 aa)
PITX1Homeobox protein. (313 aa)
ENSUAMP00000022339Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
ENSUAMP00000022336Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (163 aa)
OLIG3Oligodendrocyte transcription factor 3. (272 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
IL7Interleukin 7. (152 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
TBX22T-box transcription factor 22. (524 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
TBX18T-box transcription factor 18. (612 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
GAP43Growth associated protein 43. (222 aa)
ENSUAMP00000020431Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
KIAA1549KIAA1549. (1955 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1188 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
ATOH1Atonal bHLH transcription factor 1. (356 aa)
GSX2GS homeobox 2. (312 aa)
LEO1LEO1 homolog, Paf1/RNA polymerase II complex component. (618 aa)
GATA5GATA binding protein 5. (414 aa)
APC2APC regulator of WNT signaling pathway 2. (2266 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FEVFEV transcription factor, ETS family member. (237 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
IL6RInterleukin 6 receptor. (496 aa)
HOXA11Homeobox A11. (313 aa)
HOXA2Homeobox A2. (374 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
NEUROG1Neurogenin 1. (251 aa)
VWA5AVon Willebrand factor A domain containing 5A. (804 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
LHX3LIM homeobox 3. (403 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
DMRT3Doublesex and mab-3 related transcription factor 3. (476 aa)
ENSUAMP00000016112TPR_REGION domain-containing protein. (215 aa)
MYT1LMyelin transcription factor 1 like. (1198 aa)
OLIG2Oligodendrocyte transcription factor 2. (302 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
EOMESEomesodermin. (687 aa)
SOX17SRY-box transcription factor 17. (406 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
ZNF521Zinc finger protein 521. (1251 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
PRADC1Protease associated domain containing 1. (188 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (396 aa)
MYL10Myosin light chain 10. (215 aa)
PRDM14PR/SET domain 14. (566 aa)
NOTCH1Notch receptor 1. (2547 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
HOXD10Homeobox D10. (410 aa)
PMLPromyelocytic leukemia. (877 aa)
FEZF2FEZ family zinc finger 2. (443 aa)
SOX13SRY-box transcription factor 13. (621 aa)
NKX2-2NK2 homeobox 2. (273 aa)
ISL2ISL LIM homeobox 2. (359 aa)
GLI3GLI family zinc finger 3. (1413 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1294 aa)
NKX2-1NK2 homeobox 1. (370 aa)
TBX6T-box transcription factor 6. (436 aa)
LBX1Ladybird homeobox 1. (281 aa)
RTF1RTF1 homolog, Paf1/RNA polymerase II complex component. (424 aa)
ENSUAMP00000031091Uncharacterized protein. (151 aa)
MYL2Myosin light chain 2. (192 aa)
IL6Interleukin 6. (212 aa)
EDN1Endothelin 1. (202 aa)
ENSUAMP00000030325HMG box domain-containing protein. (336 aa)
ENSUAMP00000030304HH_signal domain-containing protein. (146 aa)
GSX1GS homeobox 1. (263 aa)
MITFMelanocyte inducing transcription factor. (525 aa)
IRF4Interferon regulatory factor 4. (451 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
MGAMAX dimerization protein MGA. (3115 aa)
TBXTT-box transcription factor T. (435 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
DOCK7Dedicator of cytokinesis 7; Belongs to the DOCK family. (1601 aa)
GATA3GATA binding protein 3. (444 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (419 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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