(14 nodes) Positive regulation of macrophage differentiation network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RB1	RB transcriptional corepressor 1. (870 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	IL34	Interleukin 34. (236 aa)
	CASP10	Caspase 10; Belongs to the peptidase C14A family. (481 aa)
	CASP8	Caspase 8; Belongs to the peptidase C14A family. (395 aa)
	PRKCA	Protein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
	TGFB1	Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
	TRIB1	Tribbles pseudokinase 1. (317 aa)
	ENSUAMP00000017869	Uncharacterized protein. (53 aa)
	RIPK1	Receptor interacting serine/threonine kinase 1. (550 aa)
	ENSUAMP00000025300	Non-specific serine/threonine protein kinase. (254 aa)
	FADD	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
	CSF1	Colony stimulating factor 1. (518 aa)
	HSF1	Heat shock transcription factor 1. (554 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP10	CASP8	ENSUAMP00000007994	ENSUAMP00000007996	Caspase 10; Belongs to the peptidase C14A family.	Caspase 8; Belongs to the peptidase C14A family.	0.983
CASP10	FADD	ENSUAMP00000007994	ENSUAMP00000027565	Caspase 10; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.997
CASP10	RIPK1	ENSUAMP00000007994	ENSUAMP00000019468	Caspase 10; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.958
CASP8	CASP10	ENSUAMP00000007996	ENSUAMP00000007994	Caspase 8; Belongs to the peptidase C14A family.	Caspase 10; Belongs to the peptidase C14A family.	0.983
CASP8	FADD	ENSUAMP00000007996	ENSUAMP00000027565	Caspase 8; Belongs to the peptidase C14A family.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
CASP8	RIPK1	ENSUAMP00000007996	ENSUAMP00000019468	Caspase 8; Belongs to the peptidase C14A family.	Receptor interacting serine/threonine kinase 1.	0.998
CSF1	IL34	ENSUAMP00000028977	ENSUAMP00000007911	Colony stimulating factor 1.	Interleukin 34.	0.977
CSF1	TGFB1	ENSUAMP00000028977	ENSUAMP00000012487	Colony stimulating factor 1.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.651
ENSUAMP00000025300	PRKCA	ENSUAMP00000025300	ENSUAMP00000010550	Non-specific serine/threonine protein kinase.	Protein kinase C alpha; Belongs to the protein kinase superfamily.	0.866
FADD	CASP10	ENSUAMP00000027565	ENSUAMP00000007994	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 10; Belongs to the peptidase C14A family.	0.997
FADD	CASP8	ENSUAMP00000027565	ENSUAMP00000007996	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Caspase 8; Belongs to the peptidase C14A family.	0.999
FADD	RIPK1	ENSUAMP00000027565	ENSUAMP00000019468	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	Receptor interacting serine/threonine kinase 1.	0.999
IL34	CSF1	ENSUAMP00000007911	ENSUAMP00000028977	Interleukin 34.	Colony stimulating factor 1.	0.977
LIF	TGFB1	ENSUAMP00000007868	ENSUAMP00000012487	LIF interleukin 6 family cytokine.	Transforming growth factor beta; Belongs to the TGF-beta family.	0.444
PRKCA	ENSUAMP00000025300	ENSUAMP00000010550	ENSUAMP00000025300	Protein kinase C alpha; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.866
RIPK1	CASP10	ENSUAMP00000019468	ENSUAMP00000007994	Receptor interacting serine/threonine kinase 1.	Caspase 10; Belongs to the peptidase C14A family.	0.958
RIPK1	CASP8	ENSUAMP00000019468	ENSUAMP00000007996	Receptor interacting serine/threonine kinase 1.	Caspase 8; Belongs to the peptidase C14A family.	0.998
RIPK1	FADD	ENSUAMP00000019468	ENSUAMP00000027565	Receptor interacting serine/threonine kinase 1.	FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.	0.999
TGFB1	CSF1	ENSUAMP00000012487	ENSUAMP00000028977	Transforming growth factor beta; Belongs to the TGF-beta family.	Colony stimulating factor 1.	0.651
TGFB1	LIF	ENSUAMP00000012487	ENSUAMP00000007868	Transforming growth factor beta; Belongs to the TGF-beta family.	LIF interleukin 6 family cytokine.	0.444