STRINGSTRING
FGF1 FGF1 GDF2 GDF2 IL10 IL10 ENSUAMP00000000756 ENSUAMP00000000756 ENSUAMP00000001068 ENSUAMP00000001068 HIPK2 HIPK2 TIE1 TIE1 JCAD JCAD ITGB8 ITGB8 CCL24 CCL24 ENSUAMP00000002230 ENSUAMP00000002230 SASH1 SASH1 GREM1 GREM1 PAK4 PAK4 ZNF304 ZNF304 S100A1 S100A1 PTK2B PTK2B C5 C5 CHI3L1 CHI3L1 PRKCB PRKCB MTDH MTDH CDH5 CDH5 EMILIN1 EMILIN1 STAT3 STAT3 RRAS RRAS ABL1 ABL1 PRKD1 PRKD1 NODAL NODAL ITGB1 ITGB1 VASH2 VASH2 PRKCA PRKCA EMP2 EMP2 ENSUAMP00000011462 ENSUAMP00000011462 JAK1 JAK1 PDCL3 PDCL3 FUT1 FUT1 AGO2 AGO2 SP1 SP1 HSPB1 HSPB1 BTG1 BTG1 VEGFC VEGFC APLNR APLNR ENSUAMP00000015739 ENSUAMP00000015739 ENSUAMP00000015788 ENSUAMP00000015788 PDPK1 PDPK1 RAMP2 RAMP2 PGF PGF ACVRL1 ACVRL1 TEK TEK EMC10 EMC10 ZC3H12A ZC3H12A ECM1 ECM1 ETS1 ETS1 CYP1B1 CYP1B1 ENSUAMP00000019143 ENSUAMP00000019143 VEGFB VEGFB TLR3 TLR3 HMOX1 HMOX1 PIK3R6 PIK3R6 VEGFA VEGFA CXCL8 CXCL8 SIRT1 SIRT1 PRKD2 PRKD2 TNN TNN THBS1 THBS1 KDR KDR CX3CR1 CX3CR1 LRG1 LRG1 ENSUAMP00000024617 ENSUAMP00000024617 SIRT6 SIRT6 ENSUAMP00000025300 ENSUAMP00000025300 ENSUAMP00000025740 ENSUAMP00000025740 PTGIS PTGIS HSPB6 HSPB6 CTSH CTSH EMILIN2 EMILIN2 EPHA1 EPHA1 F3 F3 ITGA5 ITGA5 ANGPT4 ANGPT4 PDCD6 PDCD6 DLL1 DLL1 ANGPTL3 ANGPTL3 CXCR3 CXCR3 SPHK1 SPHK1 ENSUAMP00000029322 ENSUAMP00000029322 C3AR1 C3AR1 ENSUAMP00000037141 ENSUAMP00000037141 NR2E1 NR2E1 C5AR1 C5AR1 CCBE1 CCBE1 ENSUAMP00000035622 ENSUAMP00000035622 ENSUAMP00000035608 ENSUAMP00000035608 ENSUAMP00000034912 ENSUAMP00000034912 HIF1A HIF1A ENSUAMP00000033951 ENSUAMP00000033951 PKM PKM PARP6 PARP6 MYDGF MYDGF JUP JUP HK2 HK2 ENSUAMP00000031246 ENSUAMP00000031246 FGF18 FGF18 VEGFD VEGFD GAB1 GAB1 FLT1 FLT1 ENG ENG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GDF2Growth differentiation factor 2. (429 aa)
IL10Interleukin 10. (178 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
ENSUAMP00000001068Ig-like domain-containing protein. (174 aa)
HIPK2Homeodomain interacting protein kinase 2. (1200 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1069 aa)
JCADJunctional cadherin 5 associated. (1372 aa)
ITGB8Integrin beta; Belongs to the integrin beta chain family. (767 aa)
CCL24C-C motif chemokine ligand 24. (119 aa)
ENSUAMP00000002230SAM domain-containing protein. (140 aa)
SASH1SAM and SH3 domain containing 1. (764 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
PAK4Non-specific serine/threonine protein kinase. (488 aa)
ZNF304Zinc finger protein 304. (617 aa)
S100A1Protein S100; Belongs to the S-100 family. (94 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (969 aa)
C5Complement C5. (1694 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (408 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (651 aa)
MTDHMetadherin. (610 aa)
CDH5Cadherin 5; Cadherins are calcium-dependent cell adhesion proteins. (783 aa)
EMILIN1Elastin microfibril interfacer 1. (1020 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
RRASRAS related. (218 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (848 aa)
NODALNodal growth differentiation factor. (348 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
VASH2Vasohibin 2. (392 aa)
PRKCAProtein kinase C alpha; Belongs to the protein kinase superfamily. (484 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (167 aa)
ENSUAMP00000011462Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (271 aa)
JAK1Tyrosine-protein kinase. (1152 aa)
PDCL3Phosducin like 3. (222 aa)
FUT1L-Fucosyltransferase; Belongs to the glycosyltransferase 11 family. (319 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (911 aa)
SP1Sp1 transcription factor. (780 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (207 aa)
BTG1BTG anti-proliferation factor 1. (155 aa)
VEGFCVascular endothelial growth factor C; Belongs to the PDGF/VEGF growth factor family. (391 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
ENSUAMP00000015739Uncharacterized protein. (122 aa)
ENSUAMP00000015788BZIP domain-containing protein. (359 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (531 aa)
RAMP2Receptor activity modifying protein 2. (100 aa)
PGFPlacental growth factor; Belongs to the PDGF/VEGF growth factor family. (170 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
TEKTEK receptor tyrosine kinase. (1125 aa)
EMC10ER membrane protein complex subunit 10. (254 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (598 aa)
ECM1Extracellular matrix protein 1. (422 aa)
ETS1ETS proto-oncogene 1, transcription factor. (531 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (543 aa)
ENSUAMP00000019143Uncharacterized protein. (303 aa)
VEGFBVascular endothelial growth factor B; Belongs to the PDGF/VEGF growth factor family. (191 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (905 aa)
HMOX1Heme oxygenase 1. (288 aa)
PIK3R6Phosphoinositide-3-kinase regulatory subunit 6. (755 aa)
VEGFAVascular endothelial growth factor A; Belongs to the PDGF/VEGF growth factor family. (516 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
SIRT1Sirtuin 1. (618 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (840 aa)
TNNTenascin N. (1408 aa)
THBS1Thrombospondin 1. (1170 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
LRG1Leucine rich alpha-2-glycoprotein 1. (354 aa)
ENSUAMP00000024617Ig-like domain-containing protein. (334 aa)
SIRT6Sirtuin 6. (338 aa)
ENSUAMP00000025300Non-specific serine/threonine protein kinase. (254 aa)
ENSUAMP00000025740Uncharacterized protein. (466 aa)
PTGISProstaglandin I2 synthase; Belongs to the cytochrome P450 family. (499 aa)
HSPB6Heat shock protein family B (small) member 6; Belongs to the small heat shock protein (HSP20) family. (163 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (372 aa)
EMILIN2Elastin microfibril interfacer 2. (1075 aa)
EPHA1EPH receptor A1. (925 aa)
F3Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. (288 aa)
ITGA5Integrin subunit alpha 5; Belongs to the integrin alpha chain family. (1067 aa)
ANGPT4Angiopoietin 4. (446 aa)
PDCD6Programmed cell death 6. (189 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (757 aa)
ANGPTL3Angiopoietin like 3. (425 aa)
CXCR3C-X-C motif chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (369 aa)
SPHK1Sphingosine kinase 1. (387 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
C3AR1Complement C3a receptor 1; Belongs to the G-protein coupled receptor 1 family. (336 aa)
ENSUAMP00000037141Uncharacterized protein. (54 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (350 aa)
CCBE1Collagen and calcium binding EGF domains 1. (337 aa)
ENSUAMP00000035622Uncharacterized protein. (662 aa)
ENSUAMP00000035608Uncharacterized protein. (85 aa)
ENSUAMP00000034912Uncharacterized protein. (714 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
ENSUAMP00000033951Uncharacterized protein. (383 aa)
PKMPyruvate kinase; Belongs to the pyruvate kinase family. (531 aa)
PARP6Poly [ADP-ribose] polymerase. (610 aa)
MYDGFMyeloid derived growth factor. (173 aa)
JUPJunction plakoglobin. (744 aa)
HK2Hexokinase 2. (898 aa)
ENSUAMP00000031246Annexin. (197 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (329 aa)
GAB1GRB2 associated binding protein 1. (721 aa)
FLT1Fms related tyrosine kinase 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1265 aa)
ENGEndoglin. (650 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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