STRINGSTRING
CITED1 CITED1 SMAD6 SMAD6 SMAD2 SMAD2 ENSUAMP00000026737 ENSUAMP00000026737 ENSUAMP00000026739 ENSUAMP00000026739 SMAD7 SMAD7 TGFBR3L TGFBR3L AXIN2 AXIN2 HIPK2 HIPK2 ANKRD1 ANKRD1 ENSUAMP00000000756 ENSUAMP00000000756 ENSUAMP00000000397 ENSUAMP00000000397 ENSUAMP00000000316 ENSUAMP00000000316 ZBTB7A ZBTB7A SNW1 SNW1 USP9X USP9X RANBP3 RANBP3 DDX5 DDX5 SMAD9 SMAD9 SAV1 SAV1 BMPR1B BMPR1B DROSHA DROSHA PML PML ENSUAMP00000034195 ENSUAMP00000034195 CREB3L1 CREB3L1 BMPR1A BMPR1A ZMIZ1 ZMIZ1 ENSUAMP00000007432 ENSUAMP00000007432 FOXH1 FOXH1 RNF111 RNF111 IPO7 IPO7 JUN JUN TGFBR2 TGFBR2 COL3A1 COL3A1 LDLRAD4 LDLRAD4 ENSUAMP00000007216 ENSUAMP00000007216 ENSUAMP00000006744 ENSUAMP00000006744 ENSUAMP00000004097 ENSUAMP00000004097 ACVR1 ACVR1 ENSUAMP00000003640 ENSUAMP00000003640 EID2 EID2 PMEPA1 PMEPA1 ENSUAMP00000024123 ENSUAMP00000024123 ENSUAMP00000017561 ENSUAMP00000017561 ACVR1B ACVR1B ACVRL1 ACVRL1 SMURF2 SMURF2 TGFBR1 TGFBR1 ENSUAMP00000016793 ENSUAMP00000016793 USP15 USP15 ZC3H3 ZC3H3 DAB2 DAB2 SKOR1 SKOR1 TOB1 TOB1 TGFBR3 TGFBR3 ENSUAMP00000010405 ENSUAMP00000010405 ENSUAMP00000010402 ENSUAMP00000010402 ENSUAMP00000010127 ENSUAMP00000010127 MYOCD MYOCD GATA4 GATA4 SKI SKI SMAD3 SMAD3 MEF2A MEF2A ENSUAMP00000023083 ENSUAMP00000023083 CITED2 CITED2 SMAD5 SMAD5 ENSUAMP00000025721 ENSUAMP00000025721 BMP2 BMP2 AXIN1 AXIN1 SKIL SKIL SMAD4 SMAD4 FERMT2 FERMT2 TGFB1I1 TGFB1I1 RANBP3L RANBP3L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (195 aa)
SMAD6Mothers against decapentaplegic homolog. (484 aa)
SMAD2Mothers against decapentaplegic homolog. (467 aa)
ENSUAMP00000026737Uncharacterized protein. (291 aa)
ENSUAMP00000026739Uncharacterized protein. (379 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (290 aa)
AXIN2Axin 2. (843 aa)
HIPK2Homeodomain interacting protein kinase 2. (1200 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (529 aa)
SNW1SNW domain containing 1. (511 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2153 aa)
RANBP3RAN binding protein 3. (581 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
SMAD9Mothers against decapentaplegic homolog. (469 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
DROSHADrosha ribonuclease III. (1337 aa)
PMLPromyelocytic leukemia. (877 aa)
ENSUAMP00000034195Uncharacterized protein. (1577 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (520 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1044 aa)
ENSUAMP00000007432Fibrillar collagen NC1 domain-containing protein. (263 aa)
FOXH1Forkhead box H1. (370 aa)
RNF111Ring finger protein 111. (985 aa)
IPO7Importin 7. (1039 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
TGFBR2TGF-beta receptor type-2; Transmembrane serine/threonine kinase forming with the TGF- beta type I serine/threonine kinase receptor, TGFBR1, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinoge [...] (567 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
LDLRAD4Low density lipoprotein receptor class A domain containing 4. (269 aa)
ENSUAMP00000007216Vps39_2 domain-containing protein. (335 aa)
ENSUAMP00000006744Uncharacterized protein. (509 aa)
ENSUAMP00000004097Uncharacterized protein. (245 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
ENSUAMP00000003640Uncharacterized protein. (101 aa)
EID2EP300 interacting inhibitor of differentiation 2. (172 aa)
PMEPA1Prostate transmembrane protein, androgen induced 1. (237 aa)
ENSUAMP00000024123Uncharacterized protein. (522 aa)
ENSUAMP00000017561Uncharacterized protein. (285 aa)
ACVR1BReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (505 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
SMURF2E3 ubiquitin-protein ligase. (736 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
ENSUAMP00000016793BZIP domain-containing protein. (179 aa)
USP15Ubiquitin specific peptidase 15; Belongs to the peptidase C19 family. (968 aa)
ZC3H3Zinc finger CCCH-type containing 3. (883 aa)
DAB2DAB adaptor protein 2. (763 aa)
SKOR1SKI family transcriptional corepressor 1. (970 aa)
TOB1Transducer of ERBB2, 1. (344 aa)
TGFBR3Transforming growth factor beta receptor 3. (808 aa)
ENSUAMP00000010405Uncharacterized protein. (120 aa)
ENSUAMP00000010402BBC domain-containing protein. (492 aa)
ENSUAMP00000010127Kindlin_2_N domain-containing protein. (70 aa)
MYOCDMyocardin. (870 aa)
GATA4GATA binding protein 4. (443 aa)
SKISKI proto-oncogene. (704 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
MEF2AMyocyte enhancer factor 2A. (466 aa)
ENSUAMP00000023083Uncharacterized protein. (485 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
ENSUAMP00000025721Uncharacterized protein. (113 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
AXIN1Axin 1. (867 aa)
SKILSKI like proto-oncogene. (684 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FERMT2Fermitin family member 2. (567 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (464 aa)
RANBP3LRAN binding protein 3 like. (394 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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