25 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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protein homology

Your Input:
	ASPDH	Aspartate dehydrogenase domain containing. (284 aa)
	NUDT12	Nudix hydrolase 12. (462 aa)
	NADK	NAD kinase. (496 aa)
	ENSUAMP00000029041	CTP_transf_like domain-containing protein. (61 aa)
	ENSUAMP00000029039	CTP_transf_like domain-containing protein. (180 aa)
	NUDT17	Nudix hydrolase 17. (295 aa)
	ENSUAMP00000026000	Uncharacterized protein. (224 aa)
	QPRT	Quinolinate phosphoribosyltransferase. (324 aa)
	NUDT13	Nudix hydrolase 13. (389 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase. (264 aa)
	NAMPT	Nicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (505 aa)
	NAXD	ATP-dependent (S)-NAD(P)H-hydrate dehydratase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Belongs to the NnrD/CARKD family. (329 aa)
	ENSUAMP00000013982	Uncharacterized protein. (305 aa)
	IDO1	Indoleamine 2,3-dioxygenase 1. (386 aa)
	NMRK1	Nicotinamide riboside kinase 1. (202 aa)
	NAPRT	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family. (538 aa)
	MROH6	Maestro heat like repeat family member 6. (705 aa)
	NAXE	NAD(P)H-hydrate epimerase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. (288 aa)
	NADSYN1	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family. (723 aa)
	NMNAT2	Nicotinamide nucleotide adenylyltransferase 2. (307 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (477 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (724 aa)
	NMNAT1	Nicotinamide-nucleotide adenylyltransferase. (280 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (422 aa)
	JOSD2	Josephin domain containing 2. (188 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASPDH	MROH6	ENSUAMP00000017658	ENSUAMP00000016193	Aspartate dehydrogenase domain containing.	Maestro heat like repeat family member 6.	0.512
ASPDH	NAPRT	ENSUAMP00000017658	ENSUAMP00000016181	Aspartate dehydrogenase domain containing.	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	0.512
ASPDH	QPRT	ENSUAMP00000017658	ENSUAMP00000036169	Aspartate dehydrogenase domain containing.	Quinolinate phosphoribosyltransferase.	0.564
ENSUAMP00000013982	HAAO	ENSUAMP00000013982	ENSUAMP00000007548	Uncharacterized protein.	3-hydroxyanthranilate 3,4-dioxygenase.	0.770
ENSUAMP00000013982	IDO1	ENSUAMP00000013982	ENSUAMP00000013993	Uncharacterized protein.	Indoleamine 2,3-dioxygenase 1.	0.947
ENSUAMP00000013982	KMO	ENSUAMP00000013982	ENSUAMP00000024694	Uncharacterized protein.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.	0.567
ENSUAMP00000013982	KYNU	ENSUAMP00000013982	ENSUAMP00000021629	Uncharacterized protein.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family.	0.975
ENSUAMP00000013982	QPRT	ENSUAMP00000013982	ENSUAMP00000036169	Uncharacterized protein.	Quinolinate phosphoribosyltransferase.	0.717
ENSUAMP00000026000	ENSUAMP00000029039	ENSUAMP00000026000	ENSUAMP00000029039	Uncharacterized protein.	CTP_transf_like domain-containing protein.	0.910
ENSUAMP00000026000	ENSUAMP00000029041	ENSUAMP00000026000	ENSUAMP00000029041	Uncharacterized protein.	CTP_transf_like domain-containing protein.	0.910
ENSUAMP00000026000	NADK	ENSUAMP00000026000	ENSUAMP00000031287	Uncharacterized protein.	NAD kinase.	0.971
ENSUAMP00000026000	NADSYN1	ENSUAMP00000026000	ENSUAMP00000024949	Uncharacterized protein.	Glutamine-dependent NAD(+) synthetase; In the C-terminal section; belongs to the NAD synthetase family.	0.967
ENSUAMP00000026000	NAPRT	ENSUAMP00000026000	ENSUAMP00000016181	Uncharacterized protein.	Nicotinate phosphoribosyltransferase; Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate. Belongs to the NAPRTase family.	0.428
ENSUAMP00000026000	NMNAT1	ENSUAMP00000026000	ENSUAMP00000021762	Uncharacterized protein.	Nicotinamide-nucleotide adenylyltransferase.	0.957
ENSUAMP00000026000	NMNAT2	ENSUAMP00000026000	ENSUAMP00000024801	Uncharacterized protein.	Nicotinamide nucleotide adenylyltransferase 2.	0.927
ENSUAMP00000026000	NUDT12	ENSUAMP00000026000	ENSUAMP00000033883	Uncharacterized protein.	Nudix hydrolase 12.	0.952
ENSUAMP00000026000	NUDT13	ENSUAMP00000026000	ENSUAMP00000006048	Uncharacterized protein.	Nudix hydrolase 13.	0.506
ENSUAMP00000029039	ENSUAMP00000026000	ENSUAMP00000029039	ENSUAMP00000026000	CTP_transf_like domain-containing protein.	Uncharacterized protein.	0.910
ENSUAMP00000029039	MROH6	ENSUAMP00000029039	ENSUAMP00000016193	CTP_transf_like domain-containing protein.	Maestro heat like repeat family member 6.	0.662
ENSUAMP00000029039	NADK	ENSUAMP00000029039	ENSUAMP00000031287	CTP_transf_like domain-containing protein.	NAD kinase.	0.934