STRINGSTRING
LIF LIF INCA1 INCA1 TP53 TP53 LIG4 LIG4 ESR1 ESR1 E2F8 E2F8 COL3A1 COL3A1 FGF10 FGF10 CAV1 CAV1 PRDX1 PRDX1 ENSUAMP00000010403 ENSUAMP00000010403 NUPR1 NUPR1 CKS1B CKS1B C1QL4 C1QL4 DAZAP1 DAZAP1 CKS2 CKS2 LZTS2 LZTS2 NGFR NGFR CDK1 CDK1 NF1 NF1 VEGFD VEGFD KAT2A KAT2A ENSUAMP00000032975 ENSUAMP00000032975 PDGFC PDGFC ENSUAMP00000033960 ENSUAMP00000033960 CD248 CD248 ENSUAMP00000037356 ENSUAMP00000037356
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LIFLIF interleukin 6 family cytokine. (202 aa)
INCA1Inhibitor of CDK, cyclin A1 interacting protein 1. (245 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
LIG4DNA ligase. (911 aa)
ESR1Estrogen receptor 1. (490 aa)
E2F8E2F transcription factor 8. (863 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
PRDX1Peroxiredoxin 1. (185 aa)
ENSUAMP00000010403Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (66 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
CKS1BCyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
C1QL4Complement C1q like 4. (215 aa)
DAZAP1DAZ associated protein 1. (428 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (74 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (669 aa)
NGFRNerve growth factor receptor. (388 aa)
CDK1Cyclin dependent kinase 1. (305 aa)
NF1Neurofibromin 1. (2845 aa)
VEGFDVascular endothelial growth factor D; Belongs to the PDGF/VEGF growth factor family. (329 aa)
KAT2AHistone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (837 aa)
ENSUAMP00000032975Uncharacterized protein. (197 aa)
PDGFCPlatelet derived growth factor C. (218 aa)
ENSUAMP00000033960Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (58 aa)
CD248CD248 molecule. (729 aa)
ENSUAMP00000037356Uncharacterized protein. (137 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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