(36 nodes) Lung alveolus development network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	SMPD3	Sphingomyelin phosphodiesterase 3. (658 aa)
	PHF14	PHD finger protein 14. (843 aa)
	MAN2A1	Alpha-mannosidase. (1096 aa)
	HS6ST1	Heparan-sulfate 6-O-sulfotransferase; 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate. (411 aa)
	LIF	LIF interleukin 6 family cytokine. (202 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
	MYOCD	Myocardin. (870 aa)
	PKDCC	Protein kinase domain containing, cytoplasmic. (452 aa)
	CIC	Capicua transcriptional repressor. (2470 aa)
	FOXA1	Forkhead box A1. (472 aa)
	ERRFI1	ERBB receptor feedback inhibitor 1. (410 aa)
	FOXF1	Forkhead box F1. (379 aa)
	HOXA5	Homeobox A5. (381 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1189 aa)
	NKIRAS1	NFKB inhibitor interacting Ras like 1. (192 aa)
	STK40	Serine/threonine kinase 40. (435 aa)
	ABCA12	ATP binding cassette subfamily A member 12. (2349 aa)
	ADA	Adenosine deaminase. (385 aa)
	KDR	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
	CREB1	cAMP responsive element binding protein 1. (341 aa)
	TMEM38B	Transmembrane protein 38B. (291 aa)
	SLC7A11	Solute carrier family 7 member 11. (466 aa)
	ENSUAMP00000024393	Uncharacterized protein. (127 aa)
	TCF21	Transcription factor 21. (179 aa)
	ATXN1L	Ataxin 1 like. (688 aa)
	LTBP3	Latent transforming growth factor beta binding protein 3. (1169 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	ENSUAMP00000030480	HARE-HTH domain-containing protein. (88 aa)
	ASXL1	ASXL transcriptional regulator 1. (1306 aa)
	NKX2-1	NK2 homeobox 1. (370 aa)
	STRA6	Stimulated by retinoic acid 6. (642 aa)
	NKIRAS2	NFKB inhibitor interacting Ras like 2. (191 aa)
	NKX2-2	NK2 homeobox 2. (273 aa)
	ENSUAMP00000033749	Uncharacterized protein. (344 aa)
	ENSUAMP00000033750	Uncharacterized protein. (66 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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node degree of proteins in your network (given the current score cut-off)

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a flat-file format describing the coordinates and colors of nodes in the network

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... protein annotations:

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATXN1L	CIC	ENSUAMP00000026332	ENSUAMP00000013353	Ataxin 1 like.	Capicua transcriptional repressor.	0.758
BMP4	BMPR2	ENSUAMP00000028868	ENSUAMP00000036920	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.990
BMP4	FGF10	ENSUAMP00000028868	ENSUAMP00000008288	Bone morphogenetic protein 4.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.758
BMP4	FOXF1	ENSUAMP00000028868	ENSUAMP00000016230	Bone morphogenetic protein 4.	Forkhead box F1.	0.500
BMP4	KDR	ENSUAMP00000028868	ENSUAMP00000023136	Bone morphogenetic protein 4.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.491
BMP4	LIF	ENSUAMP00000028868	ENSUAMP00000007868	Bone morphogenetic protein 4.	LIF interleukin 6 family cytokine.	0.568
BMPR2	BMP4	ENSUAMP00000036920	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.990
BMPR2	KDR	ENSUAMP00000036920	ENSUAMP00000023136	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.412
CIC	ATXN1L	ENSUAMP00000013353	ENSUAMP00000026332	Capicua transcriptional repressor.	Ataxin 1 like.	0.758
ENSUAMP00000024393	MAN2A1	ENSUAMP00000024393	ENSUAMP00000006805	Uncharacterized protein.	Alpha-mannosidase.	0.719
FGF10	BMP4	ENSUAMP00000008288	ENSUAMP00000028868	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Bone morphogenetic protein 4.	0.758
FGF10	KDR	ENSUAMP00000008288	ENSUAMP00000023136	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	Kinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.	0.943
FGF10	LIF	ENSUAMP00000008288	ENSUAMP00000007868	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	LIF interleukin 6 family cytokine.	0.559
FGF10	NKX2-1	ENSUAMP00000008288	ENSUAMP00000031665	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	NK2 homeobox 1.	0.515
FOXA1	NKX2-1	ENSUAMP00000014538	ENSUAMP00000031665	Forkhead box A1.	NK2 homeobox 1.	0.603
FOXA1	NKX2-2	ENSUAMP00000014538	ENSUAMP00000032566	Forkhead box A1.	NK2 homeobox 2.	0.462
FOXF1	BMP4	ENSUAMP00000016230	ENSUAMP00000028868	Forkhead box F1.	Bone morphogenetic protein 4.	0.500
FOXF1	MYOCD	ENSUAMP00000016230	ENSUAMP00000009957	Forkhead box F1.	Myocardin.	0.585
FOXF1	NKX2-2	ENSUAMP00000016230	ENSUAMP00000032566	Forkhead box F1.	NK2 homeobox 2.	0.408
FOXF1	TCF21	ENSUAMP00000016230	ENSUAMP00000024835	Forkhead box F1.	Transcription factor 21.	0.421