17 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	RARB	Retinoic acid receptor beta. (336 aa)
	ENSUAMP00000013328	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
	RARA	Retinoic acid receptor alpha. (462 aa)
	NR1D2	Nuclear receptor subfamily 1 group D member 2. (546 aa)
	ESRRG	Estrogen related receptor gamma. (435 aa)
	RXRA	Retinoid X receptor alpha. (469 aa)
	ACTN4	Actinin alpha 4. (970 aa)
	ENSUAMP00000027844	Nuc_recep-AF1 domain-containing protein. (202 aa)
	ENSUAMP00000027845	Uncharacterized protein. (347 aa)
	SNW1	SNW domain containing 1. (511 aa)
	PML	Promyelocytic leukemia. (877 aa)
	CYP26B1	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
	RXRB	Retinoid X receptor beta. (532 aa)
	RARG	Retinoic acid receptor gamma. (458 aa)
	PPARG	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
	ENSUAMP00000005111	Aldedh domain-containing protein. (208 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP26B1	ENSUAMP00000005111	ENSUAMP00000034125	ENSUAMP00000005111	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Aldedh domain-containing protein.	0.905
CYP26B1	ENSUAMP00000013328	ENSUAMP00000034125	ENSUAMP00000013328	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.905
CYP26B1	RARB	ENSUAMP00000034125	ENSUAMP00000013099	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Retinoic acid receptor beta.	0.498
CYP26B1	RARG	ENSUAMP00000034125	ENSUAMP00000003570	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	Retinoic acid receptor gamma.	0.438
ENSUAMP00000005111	CYP26B1	ENSUAMP00000005111	ENSUAMP00000034125	Aldedh domain-containing protein.	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.905
ENSUAMP00000005111	ENSUAMP00000013328	ENSUAMP00000005111	ENSUAMP00000013328	Aldedh domain-containing protein.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.939
ENSUAMP00000013328	CYP26B1	ENSUAMP00000013328	ENSUAMP00000034125	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family.	0.905
ENSUAMP00000013328	ENSUAMP00000005111	ENSUAMP00000013328	ENSUAMP00000005111	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	Aldedh domain-containing protein.	0.939
ENSUAMP00000027844	NR1D2	ENSUAMP00000027844	ENSUAMP00000019629	Nuc_recep-AF1 domain-containing protein.	Nuclear receptor subfamily 1 group D member 2.	0.441
ENSUAMP00000027844	PPARG	ENSUAMP00000027844	ENSUAMP00000002284	Nuc_recep-AF1 domain-containing protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.966
ENSUAMP00000027844	RARA	ENSUAMP00000027844	ENSUAMP00000019108	Nuc_recep-AF1 domain-containing protein.	Retinoic acid receptor alpha.	0.927
ENSUAMP00000027844	RARB	ENSUAMP00000027844	ENSUAMP00000013099	Nuc_recep-AF1 domain-containing protein.	Retinoic acid receptor beta.	0.927
ENSUAMP00000027844	RARG	ENSUAMP00000027844	ENSUAMP00000003570	Nuc_recep-AF1 domain-containing protein.	Retinoic acid receptor gamma.	0.933
ENSUAMP00000027844	RXRB	ENSUAMP00000027844	ENSUAMP00000035462	Nuc_recep-AF1 domain-containing protein.	Retinoid X receptor beta.	0.873
ENSUAMP00000027845	NR1D2	ENSUAMP00000027845	ENSUAMP00000019629	Uncharacterized protein.	Nuclear receptor subfamily 1 group D member 2.	0.441
ENSUAMP00000027845	PPARG	ENSUAMP00000027845	ENSUAMP00000002284	Uncharacterized protein.	Peroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...]	0.966
ENSUAMP00000027845	RARA	ENSUAMP00000027845	ENSUAMP00000019108	Uncharacterized protein.	Retinoic acid receptor alpha.	0.927
ENSUAMP00000027845	RARB	ENSUAMP00000027845	ENSUAMP00000013099	Uncharacterized protein.	Retinoic acid receptor beta.	0.927
ENSUAMP00000027845	RARG	ENSUAMP00000027845	ENSUAMP00000003570	Uncharacterized protein.	Retinoic acid receptor gamma.	0.933
ENSUAMP00000027845	RXRA	ENSUAMP00000027845	ENSUAMP00000026794	Uncharacterized protein.	Retinoid X receptor alpha.	0.871