STRINGSTRING
ENSUAMP00000019405 ENSUAMP00000019405 NR1D1 NR1D1 ENSUAMP00000020855 ENSUAMP00000020855 AFP AFP NRIP1 NRIP1 PRKCG PRKCG RACK1 RACK1 EGR1 EGR1 TP53 TP53 SGPL1 SGPL1 ENSUAMP00000001869 ENSUAMP00000001869 BTBD9 BTBD9 ENSUAMP00000002081 ENSUAMP00000002081 PROX1 PROX1 DYRK1A DYRK1A PPARG PPARG ENSUAMP00000002345 ENSUAMP00000002345 ID2 ID2 ADAMTS1 ADAMTS1 ATF5 ATF5 SUV39H2 SUV39H2 ENSUAMP00000003355 ENSUAMP00000003355 ENSUAMP00000004165 ENSUAMP00000004165 ENSUAMP00000004242 ENSUAMP00000004242 ATF4 ATF4 ENSUAMP00000005084 ENSUAMP00000005084 RBM4B RBM4B SETX SETX CARTPT CARTPT ANXA1 ANXA1 PER1 PER1 HES7 HES7 ENSUAMP00000006064 ENSUAMP00000006064 ENSUAMP00000006139 ENSUAMP00000006139 ESR1 ESR1 ENSUAMP00000006350 ENSUAMP00000006350 ENSUAMP00000006694 ENSUAMP00000006694 KDM2A KDM2A KCNMA1 KCNMA1 KDM5A KDM5A INHBA INHBA TP63 TP63 NPAS2 NPAS2 NAMPT NAMPT NAGLU NAGLU ENSUAMP00000009120 ENSUAMP00000009120 MAPK8 MAPK8 ENSUAMP00000009443 ENSUAMP00000009443 PTX3 PTX3 NONO NONO ENOX2 ENOX2 PRMT5 PRMT5 PRKDC PRKDC PPARA PPARA FZD4 FZD4 ENSUAMP00000011405 ENSUAMP00000011405 CIART CIART GSK3B GSK3B FOXO3 FOXO3 FOXO3B FOXO3B ENSUAMP00000012486 ENSUAMP00000012486 AXL AXL RAI1 RAI1 DBP DBP ENSUAMP00000013585 ENSUAMP00000013585 GAS2 GAS2 STAT5A STAT5A NOCT NOCT MAGED1 MAGED1 CSNK1D CSNK1D TP73 TP73 PSPC1 PSPC1 LGR4 LGR4 ZNF830 ZNF830 NHLH1 NHLH1 PRKAA2 PRKAA2 PER2 PER2 DHX9 DHX9 C3orf70 C3orf70 NTRK1 NTRK1 ENSUAMP00000017316 ENSUAMP00000017316 AANAT AANAT DNM1L DNM1L USP2 USP2 MTTP MTTP RBM4 RBM4 PDGFRA PDGFRA KDM5C KDM5C THRAP3 THRAP3 NR1D2 NR1D2 ZPBP2 ZPBP2 PROK2 PROK2 ENSUAMP00000036524 ENSUAMP00000036524 OPN4 OPN4 NCOA2 NCOA2 SFPQ SFPQ ENSUAMP00000035001 ENSUAMP00000035001 KCND1 KCND1 TIMELESS TIMELESS CRY1 CRY1 NR0B2 NR0B2 NUDT12 NUDT12 NR5A1 NR5A1 CCDC90B CCDC90B PML PML ENSUAMP00000033138 ENSUAMP00000033138 ENSUAMP00000032923 ENSUAMP00000032923 PRKAA1 PRKAA1 BMPR1B BMPR1B KDM5B KDM5B KLF10 KLF10 NFIL3 NFIL3 EP300 EP300 GPR157 GPR157 STAT5B STAT5B CAVIN3 CAVIN3 MYBBP1A MYBBP1A TYRO3 TYRO3 HUWE1 HUWE1 ENSUAMP00000030828 ENSUAMP00000030828 CREBBP CREBBP ID1 ID1 RELB RELB ID3 ID3 DDX5 DDX5 SLIT2 SLIT2 SLIT3 SLIT3 ENOX1 ENOX1 CDK5 CDK5 ARNTL ARNTL LHCGR LHCGR OGT OGT HNRNPU HNRNPU EZH2 EZH2 MAPK9 MAPK9 NHLH2 NHLH2 ADCY1 ADCY1 MYCBP2 MYCBP2 NTRK2 NTRK2 PPARGC1A PPARGC1A PTN PTN FSHR FSHR PPP1CB PPP1CB ENSUAMP00000025370 ENSUAMP00000025370 ENSUAMP00000025368 ENSUAMP00000025368 FBXW9 FBXW9 KDM8 KDM8 KIAA2013 KIAA2013 ROCK2 ROCK2 RORA RORA CDK1 CDK1 CREB1 CREB1 CRY2 CRY2 NGFR NGFR PLEKHA1 PLEKHA1 TNFAIP6 TNFAIP6 MAPK10 MAPK10 IMPDH2 IMPDH2 DDB1 DDB1 GFPT1 GFPT1 SIRT1 SIRT1 ENSUAMP00000021070 ENSUAMP00000021070
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000019405Uncharacterized protein. (70 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (600 aa)
ENSUAMP00000020855Uncharacterized protein. (512 aa)
AFPAlpha fetoprotein. (614 aa)
NRIP1Nuclear receptor interacting protein 1. (1156 aa)
PRKCGProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (714 aa)
RACK1Receptor for activated C kinase 1. (374 aa)
EGR1Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. (544 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (568 aa)
ENSUAMP00000001869Uncharacterized protein. (78 aa)
BTBD9BTB domain containing 9. (391 aa)
ENSUAMP00000002081Uncharacterized protein. (63 aa)
PROX1Prospero homeobox 1. (737 aa)
DYRK1ADual specificity tyrosine phosphorylation regulated kinase 1A. (754 aa)
PPARGPeroxisome proliferator-activated receptor gamma; Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. ARF6 acts as a key regulator of the tissue-specific adipocyte P2 (aP2) enhancer. Acts as a critical regulator of gut ho [...] (475 aa)
ENSUAMP00000002345SCHIP-1 domain-containing protein. (272 aa)
ID2Inhibitor of DNA binding 2. (134 aa)
ADAMTS1ADAM metallopeptidase with thrombospondin type 1 motif 1. (967 aa)
ATF5Activating transcription factor 5. (276 aa)
SUV39H2Histone-lysine N-methyltransferase; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily. (483 aa)
ENSUAMP00000003355Uncharacterized protein. (76 aa)
ENSUAMP00000004165Uncharacterized protein. (72 aa)
ENSUAMP00000004242Uncharacterized protein. (138 aa)
ATF4Activating transcription factor 4. (351 aa)
ENSUAMP00000005084Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (385 aa)
RBM4BRNA binding motif protein 4B. (359 aa)
SETXSenataxin. (2692 aa)
CARTPTCART prepropeptide. (128 aa)
ANXA1Annexin. (345 aa)
PER1Period circadian regulator 1. (1293 aa)
HES7Hes family bHLH transcription factor 7. (183 aa)
ENSUAMP00000006064Uncharacterized protein. (80 aa)
ENSUAMP00000006139BHLH domain-containing protein. (282 aa)
ESR1Estrogen receptor 1. (490 aa)
ENSUAMP00000006350Uncharacterized protein. (85 aa)
ENSUAMP00000006694SER_THR_PHOSPHATASE domain-containing protein. (148 aa)
KDM2ALysine demethylase 2A. (1075 aa)
KCNMA1Potassium calcium-activated channel subfamily M alpha 1. (1143 aa)
KDM5ALysine demethylase 5A. (1471 aa)
INHBAInhibin subunit beta A. (424 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
NPAS2Neuronal PAS domain protein 2. (822 aa)
NAMPTNicotinamide phosphoribosyltransferase; Belongs to the NAPRTase family. (505 aa)
NAGLUN-acetyl-alpha-glucosaminidase. (696 aa)
ENSUAMP00000009120Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (436 aa)
MAPK8Mitogen-activated protein kinase. (456 aa)
ENSUAMP00000009443JmjN domain-containing protein. (90 aa)
PTX3Pentraxin 3. (357 aa)
NONONon-POU domain containing octamer binding. (467 aa)
ENOX2Ecto-NOX disulfide-thiol exchanger 2. (610 aa)
PRMT5Protein arginine N-methyltransferase 5; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA); Belongs to the class I-like SAM-binding methyltransferase superfamily. (637 aa)
PRKDCProtein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3341 aa)
PPARAPeroxisome proliferator activated receptor alpha. (503 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
ENSUAMP00000011405Uncharacterized protein. (482 aa)
CIARTCircadian associated repressor of transcription. (385 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
FOXO3Forkhead box O3. (453 aa)
FOXO3BForkhead box O3B. (244 aa)
ENSUAMP00000012486Uncharacterized protein. (314 aa)
AXLAXL receptor tyrosine kinase. (898 aa)
RAI1Retinoic acid induced 1. (1889 aa)
DBPD-box binding PAR bZIP transcription factor. (325 aa)
ENSUAMP00000013585Uncharacterized protein. (588 aa)
GAS2Growth arrest specific 2. (314 aa)
STAT5ASignal transducer and activator of transcription. (797 aa)
NOCTNocturnin. (432 aa)
MAGED1MAGE family member D1. (821 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
TP73Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (634 aa)
PSPC1Paraspeckle component 1. (349 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (971 aa)
ZNF830Zinc finger protein 830. (370 aa)
NHLH1Nescient helix-loop-helix 1. (133 aa)
PRKAA2Non-specific serine/threonine protein kinase. (525 aa)
PER2Period circadian regulator 2. (1267 aa)
DHX9DExH-box helicase 9. (1276 aa)
C3orf70Chromosome 3 open reading frame 70. (250 aa)
NTRK1Tyrosine-protein kinase receptor. (787 aa)
ENSUAMP00000017316F-box domain-containing protein. (71 aa)
AANATAralkylamine N-acetyltransferase. (207 aa)
DNM1LDynamin 1 like; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (736 aa)
USP2Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (606 aa)
MTTPMicrosomal triglyceride transfer protein. (811 aa)
RBM4RNA binding motif protein 4. (365 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KDM5CLysine demethylase 5C. (1523 aa)
THRAP3Thyroid hormone receptor associated protein 3. (958 aa)
NR1D2Nuclear receptor subfamily 1 group D member 2. (546 aa)
ZPBP2Zona pellucida binding protein 2. (326 aa)
PROK2Prokineticin 2. (129 aa)
ENSUAMP00000036524Uncharacterized protein. (347 aa)
OPN4Opsin 4. (472 aa)
NCOA2Nuclear receptor coactivator 2. (945 aa)
SFPQSplicing factor proline and glutamine rich. (406 aa)
ENSUAMP00000035001Uncharacterized protein. (321 aa)
KCND1Potassium voltage-gated channel subfamily D member 1; Belongs to the potassium channel family. (647 aa)
TIMELESSTimeless circadian regulator. (1207 aa)
CRY1Cryptochrome circadian regulator 1. (587 aa)
NR0B2Nuclear receptor subfamily 0 group B member 2. (301 aa)
NUDT12Nudix hydrolase 12. (462 aa)
NR5A1Nuclear receptor subfamily 5 group A member 1. (461 aa)
CCDC90BCoiled-coil domain containing 90B. (254 aa)
PMLPromyelocytic leukemia. (877 aa)
ENSUAMP00000033138Uncharacterized protein. (153 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
PRKAA1Non-specific serine/threonine protein kinase. (559 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
KDM5BLysine demethylase 5B. (1039 aa)
KLF10Kruppel like factor 10. (480 aa)
NFIL3Nuclear factor, interleukin 3 regulated. (462 aa)
EP300E1A binding protein p300. (2399 aa)
GPR157G protein-coupled receptor 157. (334 aa)
STAT5BSignal transducer and activator of transcription. (784 aa)
CAVIN3Caveolae associated protein 3. (261 aa)
MYBBP1AMYB binding protein 1a. (1318 aa)
TYRO3TYRO3 protein tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. (898 aa)
HUWE1HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1. (4423 aa)
ENSUAMP00000030828Uncharacterized protein. (113 aa)
CREBBPCREB binding protein. (2333 aa)
ID1Inhibitor of DNA binding 1, HLH protein. (154 aa)
RELBRELB proto-oncogene, NF-kB subunit. (575 aa)
ID3Inhibitor of DNA binding 3, HLH protein. (119 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
SLIT2Slit guidance ligand 2. (1450 aa)
SLIT3Slit guidance ligand 3. (1441 aa)
ENOX1Ecto-NOX disulfide-thiol exchanger 1. (687 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
ARNTLAryl hydrocarbon receptor nuclear translocator like. (626 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (673 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (978 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
MAPK9Mitogen-activated protein kinase. (433 aa)
NHLH2Nescient helix-loop-helix 2. (135 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1119 aa)
MYCBP2MYC binding protein 2. (4749 aa)
NTRK2Tyrosine-protein kinase receptor. (800 aa)
PPARGC1APPARG coactivator 1 alpha. (761 aa)
PTNPleiotrophin. (218 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (691 aa)
PPP1CBSerine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (327 aa)
ENSUAMP00000025370Uncharacterized protein. (358 aa)
ENSUAMP00000025368TNFR-Cys domain-containing protein. (263 aa)
FBXW9F-box and WD repeat domain containing 9. (478 aa)
KDM8Lysine demethylase 8. (415 aa)
KIAA2013KIAA2013. (630 aa)
ROCK2Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1384 aa)
RORARAR related orphan receptor A. (522 aa)
CDK1Cyclin dependent kinase 1. (305 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
CRY2Cryptochrome circadian regulator 2. (604 aa)
NGFRNerve growth factor receptor. (388 aa)
PLEKHA1Pleckstrin homology domain containing A1. (374 aa)
TNFAIP6TNF alpha induced protein 6. (277 aa)
MAPK10Mitogen-activated protein kinase. (422 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors. (514 aa)
DDB1Damage specific DNA binding protein 1. (1151 aa)
GFPT1Glutamine--fructose-6-phosphate transaminase 1. (595 aa)
SIRT1Sirtuin 1. (618 aa)
ENSUAMP00000021070Uncharacterized protein. (833 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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