STRINGSTRING
LGR4 LGR4 CCDC103 CCDC103 TBX2 TBX2 WNT11 WNT11 SFRP1 SFRP1 FGF9 FGF9 ENSUAMP00000005111 ENSUAMP00000005111 ENSUAMP00000006083 ENSUAMP00000006083 YIPF6 YIPF6 CHD8 CHD8 TIGAR TIGAR ALX4 ALX4 NKX3-2 NKX3-2 COL3A1 COL3A1 KCNQ1 KCNQ1 TP63 TP63 FGF10 FGF10 CRKL CRKL GATA4 GATA4 FOXF2 FOXF2 SOX17 SOX17 ENSUAMP00000036217 ENSUAMP00000036217 HIF1A HIF1A NOTCH1 NOTCH1 HLX HLX AHI1 AHI1 PDGFC PDGFC CLDN18 CLDN18 SAV1 SAV1 GLI3 GLI3 AGR2 AGR2 STRA6 STRA6 NKX2-3 NKX2-3 CCKBR CCKBR ENSUAMP00000030452 ENSUAMP00000030452 ENSUAMP00000030450 ENSUAMP00000030450 ENSUAMP00000030361 ENSUAMP00000030361 ENSUAMP00000030304 ENSUAMP00000030304 PDX1 PDX1 SRC SRC ZIC3 ZIC3 TNF TNF KLF5 KLF5 IL6ST IL6ST BMP4 BMP4 CLMP CLMP IHH IHH ENSUAMP00000027843 ENSUAMP00000027843 ENSUAMP00000027842 ENSUAMP00000027842 SMO SMO SMAD3 SMAD3 SOX9 SOX9 SOX10 SOX10 SPDEF SPDEF ENSUAMP00000025477 ENSUAMP00000025477 TCF21 TCF21 EPHB3 EPHB3 ADA ADA TGFB2 TGFB2 CXCL8 CXCL8 PDGFRA PDGFRA KIT KIT GATA5 GATA5 NIPBL NIPBL HOXA5 HOXA5 ENSUAMP00000017162 ENSUAMP00000017162 FOXL1 FOXL1 FOXF1 FOXF1 HES1 HES1 NODAL NODAL MYOCD MYOCD ASCL1 ASCL1 C1GALT1 C1GALT1 ENSUAMP00000010997 ENSUAMP00000010997 ENSUAMP00000011008 ENSUAMP00000011008 COBL COBL PKDCC PKDCC RARB RARB EXT1 EXT1 MEGF8 MEGF8 ENSUAMP00000013328 ENSUAMP00000013328 PRDM1 PRDM1 NKX2-6 NKX2-6 RB1 RB1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (971 aa)
CCDC103Coiled-coil domain containing 103. (242 aa)
TBX2T-box transcription factor 2. (697 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSUAMP00000005111Aldedh domain-containing protein. (208 aa)
ENSUAMP00000006083Dynein assembly factor 1, axonemal. (316 aa)
YIPF6Protein YIPF. (236 aa)
CHD8Chromodomain helicase DNA binding protein 8. (1832 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (269 aa)
ALX4ALX homeobox 4. (408 aa)
NKX3-2NK3 homeobox 2. (331 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (672 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
GATA4GATA binding protein 4. (443 aa)
FOXF2Forkhead box F2. (448 aa)
SOX17SRY-box transcription factor 17. (406 aa)
ENSUAMP00000036217Uncharacterized protein. (186 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
NOTCH1Notch receptor 1. (2547 aa)
HLXH2.0 like homeobox. (454 aa)
AHI1Abelson helper integration site 1. (1054 aa)
PDGFCPlatelet derived growth factor C. (218 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
GLI3GLI family zinc finger 3. (1413 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (196 aa)
STRA6Stimulated by retinoic acid 6. (642 aa)
NKX2-3NK2 homeobox 3. (318 aa)
CCKBRCholecystokinin B receptor; Belongs to the G-protein coupled receptor 1 family. (444 aa)
ENSUAMP00000030452Uncharacterized protein. (144 aa)
ENSUAMP00000030450Uncharacterized protein. (1283 aa)
ENSUAMP00000030361Uncharacterized protein. (285 aa)
ENSUAMP00000030304HH_signal domain-containing protein. (146 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
SRCTyrosine-protein kinase. (557 aa)
ZIC3Uncharacterized protein. (466 aa)
TNFTumor necrosis factor; Belongs to the tumor necrosis factor family. (230 aa)
KLF5Kruppel like factor 5. (442 aa)
IL6STInterleukin 6 signal transducer. (918 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CLMPCXADR like membrane protein. (359 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (419 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SOX9SRY-box transcription factor 9. (484 aa)
SOX10SRY-box transcription factor 10. (465 aa)
SPDEFSAM pointed domain containing ETS transcription factor. (335 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
TCF21Transcription factor 21. (179 aa)
EPHB3EPH receptor B3. (1000 aa)
ADAAdenosine deaminase. (385 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
CXCL8Multifunctional fusion protein; Belongs to the intercrine alpha (chemokine CxC) family. (101 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (999 aa)
GATA5GATA binding protein 5. (414 aa)
NIPBLNipped-B protein. (1833 aa)
HOXA5Homeobox A5. (381 aa)
ENSUAMP00000017162Uncharacterized protein. (137 aa)
FOXL1Forkhead box L1. (345 aa)
FOXF1Forkhead box F1. (379 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
NODALNodal growth differentiation factor. (348 aa)
MYOCDMyocardin. (870 aa)
ASCL1Achaete-scute family bHLH transcription factor 1. (213 aa)
C1GALT1Glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1; Glycosyltransferase that generates the core 1 O-glycan Gal- beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins; Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily. (359 aa)
ENSUAMP00000010997TPR_REGION domain-containing protein. (150 aa)
ENSUAMP00000011008Uncharacterized protein. (538 aa)
COBLCordon-bleu WH2 repeat protein. (1250 aa)
PKDCCProtein kinase domain containing, cytoplasmic. (452 aa)
RARBRetinoic acid receptor beta. (336 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
MEGF8Multiple EGF like domains 8. (2820 aa)
ENSUAMP00000013328Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
PRDM1PR/SET domain 1. (846 aa)
NKX2-6NK2 homeobox 6. (268 aa)
RB1RB transcriptional corepressor 1. (870 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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