STRINGSTRING
CBY1 CBY1 VWA5B2 VWA5B2 NOG NOG ENSUAMP00000001962 ENSUAMP00000001962 PROX1 PROX1 GREM1 GREM1 TBX5 TBX5 ENSUAMP00000002615 ENSUAMP00000002615 NKX2-5 NKX2-5 DSP DSP ENSUAMP00000004638 ENSUAMP00000004638 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 FGF9 FGF9 ENSUAMP00000005111 ENSUAMP00000005111 MYL7 MYL7 ENSUAMP00000005311 ENSUAMP00000005311 TNNI1 TNNI1 CSRP3 CSRP3 TNNC1 TNNC1 ENSUAMP00000007554 ENSUAMP00000007554 FOXH1 FOXH1 ALPK3 ALPK3 PRKAR1B PRKAR1B PRMT1 PRMT1 PTCD2 PTCD2 NRAP NRAP WNT2 WNT2 MYOCD MYOCD ITGB1 ITGB1 ENSUAMP00000010858 ENSUAMP00000010858 ENSUAMP00000010867 ENSUAMP00000010867 TENM4 TENM4 MYLK3 MYLK3 ENSUAMP00000011392 ENSUAMP00000011392 TCAP TCAP ADPRH ADPRH ENSUAMP00000012276 ENSUAMP00000012276 BVES BVES RARB RARB ENSUAMP00000013328 ENSUAMP00000013328 NKX2-6 NKX2-6 VWA5B1 VWA5B1 IRX3 IRX3 SGCG SGCG ENSUAMP00000015680 ENSUAMP00000015680 MAML1 MAML1 ACADM ACADM BMP10 BMP10 ARID2 ARID2 TGFBR1 TGFBR1 VWA5A VWA5A ENSUAMP00000017162 ENSUAMP00000017162 LMNA LMNA NPRL3 NPRL3 ENSUAMP00000017830 ENSUAMP00000017830 PLN PLN SMAD4 SMAD4 GATA5 GATA5 PDGFRA PDGFRA MYBPC3 MYBPC3 ZFPM2 ZFPM2 MTOR MTOR SRF SRF TGFB2 TGFB2 DLL4 DLL4 GJA5 GJA5 BMP2 BMP2 ENSUAMP00000021972 ENSUAMP00000021972 LRRC10B LRRC10B ACTN2 ACTN2 NDUFV2 NDUFV2 MEF2A MEF2A ENSUAMP00000023559 ENSUAMP00000023559 ATG5 ATG5 LRP2 LRP2 HAND1 HAND1 WNT8A WNT8A XIRP2 XIRP2 TBX20 TBX20 JARID2 JARID2 PPP1R13L PPP1R13L ENSUAMP00000026324 ENSUAMP00000026324 ENSUAMP00000026326 ENSUAMP00000026326 SMAD7 SMAD7 SLC9A1 SLC9A1 ENSUAMP00000028668 ENSUAMP00000028668 BMP4 BMP4 HNRNPU HNRNPU MEF2C MEF2C ZIC3 ZIC3 ENG ENG MYLK2 MYLK2 MYL2 MYL2 CAV3 CAV3 ASB2 ASB2 TSC1 TSC1 SAV1 SAV1 ENSUAMP00000032923 ENSUAMP00000032923 CXADR CXADR PRKAR1A PRKAR1A CHD7 CHD7 FHL2 FHL2 MED1 MED1 NOTCH1 NOTCH1 NEB NEB ENSUAMP00000034792 ENSUAMP00000034792 ENSUAMP00000035159 ENSUAMP00000035159 MYL10 MYL10 ENSUAMP00000035960 ENSUAMP00000035960 BMPR1A BMPR1A ZMPSTE24 ZMPSTE24 ENSUAMP00000036515 ENSUAMP00000036515 DIPK2A DIPK2A ENSUAMP00000000384 ENSUAMP00000000384 ENSUAMP00000000600 ENSUAMP00000000600 ENSUAMP00000000756 ENSUAMP00000000756 PKP2 PKP2 ENSUAMP00000001105 ENSUAMP00000001105 ANKRD1 ANKRD1 TBX2 TBX2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CBY1Chibby family member 1, beta catenin antagonist. (127 aa)
VWA5B2Von Willebrand factor A domain containing 5B2. (1245 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ENSUAMP00000001962Uncharacterized protein. (141 aa)
PROX1Prospero homeobox 1. (737 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
TBX5T-box transcription factor 5. (517 aa)
ENSUAMP00000002615annotation not available (396 aa)
NKX2-5NK2 homeobox 5. (323 aa)
DSPDesmoplakin. (2884 aa)
ENSUAMP00000004638Uncharacterized protein. (148 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
ENSUAMP00000005111Aldedh domain-containing protein. (208 aa)
MYL7Myosin light chain 7. (178 aa)
ENSUAMP00000005311Uncharacterized protein. (1199 aa)
TNNI1Troponin I1, slow skeletal type. (185 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (158 aa)
ENSUAMP00000007554Uncharacterized protein. (354 aa)
FOXH1Forkhead box H1. (370 aa)
ALPK3Alpha kinase 3. (1619 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (377 aa)
PRMT1Protein arginine methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (353 aa)
PTCD2Pentatricopeptide repeat domain 2. (427 aa)
NRAPNebulin related anchoring protein. (1729 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
MYOCDMyocardin. (870 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
ENSUAMP00000010858Myosin_tail_1 domain-containing protein. (890 aa)
ENSUAMP00000010867Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (207 aa)
TENM4Teneurin transmembrane protein 4. (2640 aa)
MYLK3Myosin light chain kinase 3. (791 aa)
ENSUAMP00000011392Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (762 aa)
TCAPTitin-cap. (167 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
ENSUAMP00000012276B30.2/SPRY domain-containing protein. (334 aa)
BVESBlood vessel epicardial substance. (323 aa)
RARBRetinoic acid receptor beta. (336 aa)
ENSUAMP00000013328Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
NKX2-6NK2 homeobox 6. (268 aa)
VWA5B1Von Willebrand factor A domain containing 5B1. (1209 aa)
IRX3Iroquois homeobox 3. (502 aa)
SGCGSarcoglycan gamma. (182 aa)
ENSUAMP00000015680Uncharacterized protein. (92 aa)
MAML1Mastermind like transcriptional coactivator 1. (933 aa)
ACADMAcyl-CoA dehydrogenase medium chain. (421 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ARID2AT-rich interaction domain 2. (1776 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
VWA5AVon Willebrand factor A domain containing 5A. (804 aa)
ENSUAMP00000017162Uncharacterized protein. (137 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (671 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
GATA5GATA binding protein 5. (414 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
MYBPC3Myosin binding protein C, cardiac. (1245 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1193 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
SRFSerum response factor. (507 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
ENSUAMP00000021972Uncharacterized protein. (778 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
ACTN2Actinin alpha 2. (894 aa)
NDUFV2NADH:ubiquinone oxidoreductase core subunit V2. (249 aa)
MEF2AMyocyte enhancer factor 2A. (466 aa)
ENSUAMP00000023559Uncharacterized protein. (132 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
LRP2LDL receptor related protein 2. (4684 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
XIRP2Xin actin binding repeat containing 2. (3766 aa)
TBX20T-box transcription factor 20. (448 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1160 aa)
PPP1R13LProtein phosphatase 1 regulatory subunit 13 like. (799 aa)
ENSUAMP00000026324Uncharacterized protein. (168 aa)
ENSUAMP00000026326SH3 domain-containing protein. (99 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
ENSUAMP00000028668Uncharacterized protein. (138 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ZIC3Uncharacterized protein. (466 aa)
ENGEndoglin. (650 aa)
MYLK2Myosin light chain kinase 2. (615 aa)
MYL2Myosin light chain 2. (192 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (630 aa)
TSC1TSC complex subunit 1. (1168 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
CXADRUncharacterized protein. (350 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2987 aa)
FHL2Four and a half LIM domains 2. (279 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
NOTCH1Notch receptor 1. (2547 aa)
NEBNebulin. (7814 aa)
ENSUAMP00000034792Uncharacterized protein. (279 aa)
ENSUAMP00000035159Uncharacterized protein. (321 aa)
MYL10Myosin light chain 10. (215 aa)
ENSUAMP00000035960Uncharacterized protein. (707 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
ENSUAMP00000036515Uncharacterized protein. (78 aa)
DIPK2ADivergent protein kinase domain 2A. (430 aa)
ENSUAMP00000000384NAD_binding_6 domain-containing protein. (147 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
PKP2Plakophilin 2. (829 aa)
ENSUAMP00000001105Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (396 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
TBX2T-box transcription factor 2. (697 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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