STRINGSTRING
ENSUAMP00000000600 ENSUAMP00000000600 GDF2 GDF2 ENSUAMP00000000563 ENSUAMP00000000563 TIE1 TIE1 TBX2 TBX2 WNT6 WNT6 ENSUAMP00000002472 ENSUAMP00000002472 ENSUAMP00000003003 ENSUAMP00000003003 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 ENSUAMP00000004918 ENSUAMP00000004918 ESR1 ESR1 ENSUAMP00000006289 ENSUAMP00000006289 MKS1 MKS1 SEMA3E SEMA3E PAK1 PAK1 DAG1 DAG1 ENSUAMP00000007637 ENSUAMP00000007637 PTCH1 PTCH1 NFATC4 NFATC4 FGF10 FGF10 SPRY2 SPRY2 RDH10 RDH10 HHIP HHIP DLG5 DLG5 ENSUAMP00000012266 ENSUAMP00000012266 RASIP1 RASIP1 GREB1 GREB1 EXT1 EXT1 ENSUAMP00000013585 ENSUAMP00000013585 ENSUAMP00000014407 ENSUAMP00000014407 FOXA1 FOXA1 FOXF1 FOXF1 AREG AREG ENSUAMP00000017478 ENSUAMP00000017478 ENSUAMP00000017830 ENSUAMP00000017830 HOXA5 HOXA5 HOXA11 HOXA11 SMAD4 SMAD4 EPHA2 EPHA2 CELSR1 CELSR1 CTNNBIP1 CTNNBIP1 SRF SRF ESRP2 ESRP2 EYA1 EYA1 ENSUAMP00000020431 ENSUAMP00000020431 KRAS KRAS DLL4 DLL4 ENSUAMP00000021186 ENSUAMP00000021186 BMP2 BMP2 GPC3 GPC3 GDNF GDNF ENSUAMP00000021954 ENSUAMP00000021954 STK4 STK4 KDR KDR WT1 WT1 CITED1 CITED1 TCF21 TCF21 SPRY1 SPRY1 PAX8 PAX8 LRP5 LRP5 ENSUAMP00000025477 ENSUAMP00000025477 TBX20 TBX20 ENSUAMP00000025912 ENSUAMP00000025912 SOX9 SOX9 ENSUAMP00000027148 ENSUAMP00000027148 CTSH CTSH NRARP NRARP ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 ENSUAMP00000028270 ENSUAMP00000028270 ENSUAMP00000028271 ENSUAMP00000028271 IHH IHH CTSZ CTSZ BMP4 BMP4 CSF1 CSF1 MMP14 MMP14 ENSUAMP00000029322 ENSUAMP00000029322 PKD2 PKD2 FGF1 FGF1 GREB1L GREB1L SLIT2 SLIT2 ENG ENG SRC SRC ENSUAMP00000030304 ENSUAMP00000030304 EDN1 EDN1 ADAMTS16 ADAMTS16 BTRC BTRC NKX2-1 NKX2-1 DLG1 DLG1 GBX2 GBX2 NPNT NPNT GLI3 GLI3 KDM5B KDM5B PML PML ILK ILK MED1 MED1 NOTCH1 NOTCH1 DDR1 DDR1 TIMELESS TIMELESS VDR VDR PHB2 PHB2 WNT1 WNT1 ENSUAMP00000035777 ENSUAMP00000035777 WNT9B WNT9B LHX1 LHX1 TMEM59L TMEM59L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000000600Uncharacterized protein. (130 aa)
GDF2Growth differentiation factor 2. (429 aa)
ENSUAMP00000000563Uncharacterized protein. (1604 aa)
TIE1Tyrosine kinase with immunoglobulin like and EGF like domains 1. (1069 aa)
TBX2T-box transcription factor 2. (697 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
ENSUAMP00000002472Uncharacterized protein. (101 aa)
ENSUAMP00000003003Plexin_cytopl domain-containing protein. (490 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
ENSUAMP00000004918Homeobox domain-containing protein. (230 aa)
ESR1Estrogen receptor 1. (490 aa)
ENSUAMP00000006289Uncharacterized protein. (158 aa)
MKS1MKS transition zone complex subunit 1. (689 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
DAG1Dystroglycan 1. (892 aa)
ENSUAMP00000007637Uncharacterized protein. (172 aa)
PTCH1Patched 1. (1453 aa)
NFATC4Nuclear factor of activated T cells 4. (911 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
HHIPHedgehog interacting protein. (508 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1866 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
RASIP1Ras interacting protein 1. (945 aa)
GREB1Uncharacterized protein. (1953 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
ENSUAMP00000013585Uncharacterized protein. (588 aa)
ENSUAMP00000014407annotation not available (101 aa)
FOXA1Forkhead box A1. (472 aa)
FOXF1Forkhead box F1. (379 aa)
AREGAmphiregulin. (257 aa)
ENSUAMP00000017478Guanylate kinase-like domain-containing protein. (307 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
HOXA5Homeobox A5. (381 aa)
HOXA11Homeobox A11. (313 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
EPHA2EPH receptor A2. (966 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2650 aa)
CTNNBIP1Catenin beta interacting protein 1. (70 aa)
SRFSerum response factor. (507 aa)
ESRP2Epithelial splicing regulatory protein 2. (699 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
ENSUAMP00000020431Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
ENSUAMP00000021186Uncharacterized protein. (404 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
ENSUAMP00000021954Uncharacterized protein. (209 aa)
STK4Serine/threonine kinase 4. (487 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1282 aa)
WT1WT1 transcription factor. (522 aa)
CITED1Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (195 aa)
TCF21Transcription factor 21. (179 aa)
SPRY1Sprouty RTK signaling antagonist 1. (319 aa)
PAX8Paired box 8. (458 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
TBX20T-box transcription factor 20. (448 aa)
ENSUAMP00000025912Uncharacterized protein. (134 aa)
SOX9SRY-box transcription factor 9. (484 aa)
ENSUAMP00000027148Uncharacterized protein. (221 aa)
CTSHCathepsin H; Belongs to the peptidase C1 family. (372 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
ENSUAMP00000028270Uncharacterized protein. (220 aa)
ENSUAMP00000028271Uncharacterized protein. (459 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (419 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (305 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
CSF1Colony stimulating factor 1. (518 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (897 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1923 aa)
SLIT2Slit guidance ligand 2. (1450 aa)
ENGEndoglin. (650 aa)
SRCTyrosine-protein kinase. (557 aa)
ENSUAMP00000030304HH_signal domain-containing protein. (146 aa)
EDN1Endothelin 1. (202 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1250 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
NKX2-1NK2 homeobox 1. (370 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (806 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
NPNTNephronectin. (462 aa)
GLI3GLI family zinc finger 3. (1413 aa)
KDM5BLysine demethylase 5B. (1039 aa)
PMLPromyelocytic leukemia. (877 aa)
ILKIntegrin linked kinase. (503 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
NOTCH1Notch receptor 1. (2547 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (936 aa)
TIMELESSTimeless circadian regulator. (1207 aa)
VDRVitamin D receptor. (427 aa)
PHB2Prohibitin. (297 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
LHX1LIM homeobox 1. (406 aa)
TMEM59LTransmembrane protein 59 like. (350 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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