STRINGSTRING
HTR2B HTR2B ENSUAMP00000000600 ENSUAMP00000000600 MSX1 MSX1 NOG NOG LRP6 LRP6 ENSUAMP00000002165 ENSUAMP00000002165 WNT11 WNT11 ENSUAMP00000002679 ENSUAMP00000002679 FLNA FLNA CYP26C1 CYP26C1 ENSUAMP00000003640 ENSUAMP00000003640 ACVR1 ACVR1 SFRP1 SFRP1 ENSUAMP00000004593 ENSUAMP00000004593 TRIM28 TRIM28 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 ENSUAMP00000005111 ENSUAMP00000005111 PEF1 PEF1 ENSUAMP00000005739 ENSUAMP00000005739 EFNB1 EFNB1 SEMA3E SEMA3E SEMA6D SEMA6D HAND2 HAND2 SEMA3G SEMA3G FGF10 FGF10 DDX17 DDX17 LOXL2 LOXL2 RDH10 RDH10 ENSUAMP00000009188 ENSUAMP00000009188 HES1 HES1 GSC GSC WNT2 WNT2 DLG5 DLG5 TGFBR3 TGFBR3 PHACTR4 PHACTR4 SEMA6A SEMA6A RADIL RADIL SEMA4A SEMA4A TGFBR1 TGFBR1 SOX8 SOX8 SEMA7A SEMA7A ENSUAMP00000015416 ENSUAMP00000015416 ENSUAMP00000015361 ENSUAMP00000015361 ENSUAMP00000013636 ENSUAMP00000013636 MAPK1 MAPK1 ENSUAMP00000013328 ENSUAMP00000013328 EXT1 EXT1 TGFB1 TGFB1 ENSUAMP00000012266 ENSUAMP00000012266 GSK3B GSK3B FAM83D FAM83D PHOX2B PHOX2B WWTR1 WWTR1 SEMA3F SEMA3F SEMA3B SEMA3B NOLC1 NOLC1 BMPR1A BMPR1A SEMA6C SEMA6C ENSUAMP00000035777 ENSUAMP00000035777 SNAI1 SNAI1 TASOR TASOR OSR1 OSR1 JAG1 JAG1 HIF1A HIF1A SEMA3D SEMA3D NOTCH1 NOTCH1 TCOF1 TCOF1 FN1 FN1 NRTN NRTN GBX2 GBX2 TMEM100 TMEM100 MAPK3 MAPK3 RET RET CORO1C CORO1C SEMA4C SEMA4C ANXA6 ANXA6 EDN1 EDN1 DDX5 DDX5 KITLG KITLG ENG ENG MEF2C MEF2C BMP4 BMP4 PDCD6 PDCD6 LOXL3 LOXL3 RFLNB RFLNB TGFBR3L TGFBR3L SMO SMO EFNA1 EFNA1 SIX2 SIX2 SOX9 SOX9 SOX10 SOX10 RANBP3L RANBP3L ENSUAMP00000025721 ENSUAMP00000025721 TBX20 TBX20 SEMA3C SEMA3C SEMA4B SEMA4B RTN4 RTN4 WNT8A WNT8A FRZB FRZB TCF21 TCF21 SEMA6B SEMA6B SEMA4F SEMA4F AKNA AKNA SEMA4G SEMA4G KLHL12 KLHL12 CITED2 CITED2 AMER1 AMER1 WNT16 WNT16 ENSUAMP00000021954 ENSUAMP00000021954 GDNF GDNF BMP2 BMP2 HAS2 HAS2 ENSUAMP00000021252 ENSUAMP00000021252 NRP2 NRP2 TGFB2 TGFB2 SEMA4D SEMA4D NOTCH4 NOTCH4 ENSUAMP00000020075 ENSUAMP00000020075 ENSUAMP00000020068 ENSUAMP00000020068 ENSUAMP00000020065 ENSUAMP00000020065 ROCK1 ROCK1 SNAI2 SNAI2 SMAD4 SMAD4 WNT10A WNT10A ADAM15 ADAM15 ENSUAMP00000017830 ENSUAMP00000017830
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
MSX1Msh homeobox 1. (303 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
LRP6LDL receptor related protein 6. (1431 aa)
ENSUAMP00000002165Sema domain-containing protein; Belongs to the semaphorin family. (424 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSUAMP00000002679Uncharacterized protein. (108 aa)
FLNAFilamin A. (1660 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
ENSUAMP00000003640Uncharacterized protein. (101 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
ENSUAMP00000004593Uncharacterized protein. (64 aa)
TRIM28Tripartite motif containing 28. (832 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
ENSUAMP00000005111Aldedh domain-containing protein. (208 aa)
PEF1Penta-EF-hand domain containing 1. (289 aa)
ENSUAMP00000005739BTB domain-containing protein. (58 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (328 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (712 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (214 aa)
DDX17DEAD-box helicase 17; Belongs to the DEAD box helicase family. (715 aa)
LOXL2Lysyl oxidase like 2. (779 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ENSUAMP00000009188Sema domain-containing protein; Belongs to the semaphorin family. (541 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
GSCGoosecoid homeobox. (256 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1866 aa)
TGFBR3Transforming growth factor beta receptor 3. (808 aa)
PHACTR4Phosphatase and actin regulator. (706 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (619 aa)
RADILRap associating with DIL domain. (1206 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (755 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
SOX8SRY-box transcription factor 8. (449 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (663 aa)
ENSUAMP00000015416Uncharacterized protein. (479 aa)
ENSUAMP00000015361CUB domain-containing protein. (131 aa)
ENSUAMP00000013636Uncharacterized protein. (265 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ENSUAMP00000013328Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (390 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
FAM83DFamily with sequence similarity 83 member D. (586 aa)
PHOX2BPaired like homeobox 2B. (289 aa)
WWTR1WW domain containing transcription regulator 1. (400 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (662 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (711 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (949 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
SNAI1Snail family transcriptional repressor 1. (259 aa)
TASORTranscription activation suppressor. (1518 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
NOTCH1Notch receptor 1. (2547 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1383 aa)
FN1Fibronectin 1. (2385 aa)
NRTNNeurturin. (157 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
TMEM100Transmembrane protein 100. (134 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1121 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
ANXA6Annexin. (673 aa)
EDN1Endothelin 1. (202 aa)
DDX5DEAD-box helicase 5; Belongs to the DEAD box helicase family. (614 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
ENGEndoglin. (650 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
PDCD6Programmed cell death 6. (189 aa)
LOXL3Lysyl oxidase like 3. (679 aa)
RFLNBRefilin B. (215 aa)
TGFBR3LTransforming growth factor beta receptor 3 like. (290 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (205 aa)
SIX2SIX homeobox 2. (296 aa)
SOX9SRY-box transcription factor 9. (484 aa)
SOX10SRY-box transcription factor 10. (465 aa)
RANBP3LRAN binding protein 3 like. (394 aa)
ENSUAMP00000025721Uncharacterized protein. (113 aa)
TBX20T-box transcription factor 20. (448 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (831 aa)
RTN4Reticulon. (951 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
FRZBFrizzled related protein. (298 aa)
TCF21Transcription factor 21. (179 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (764 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (762 aa)
AKNAAT-hook transcription factor. (1427 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (822 aa)
KLHL12Kelch like family member 12. (568 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
AMER1APC membrane recruitment protein 1. (1132 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
ENSUAMP00000021954Uncharacterized protein. (209 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
HAS2Hyaluronan synthase 2. (541 aa)
ENSUAMP00000021252Uncharacterized protein. (409 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (851 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (976 aa)
NOTCH4Notch receptor 4. (1894 aa)
ENSUAMP00000020075Uncharacterized protein. (245 aa)
ENSUAMP00000020068Uncharacterized protein. (119 aa)
ENSUAMP00000020065Uncharacterized protein. (232 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1365 aa)
SNAI2Snail family transcriptional repressor 2. (230 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
ADAM15ADAM metallopeptidase domain 15. (832 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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