STRINGSTRING
TBX2 TBX2 NOG NOG PROX1 PROX1 WNT11 WNT11 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 COL3A1 COL3A1 HAND2 HAND2 FOXH1 FOXH1 SEC24B SEC24B HES1 HES1 MYOCD MYOCD PRDM1 PRDM1 FOXF1 FOXF1 ARID2 ARID2 TGFBR1 TGFBR1 NPRL3 NPRL3 ACVRL1 ACVRL1 LDLR LDLR SRF SRF EYA1 EYA1 ENSUAMP00000020431 ENSUAMP00000020431 DLL4 DLL4 GJA5 GJA5 CITED2 CITED2 NF1 NF1 LRP2 LRP2 SMAD7 SMAD7 HPGD HPGD BMP4 BMP4 ANGPTL3 ANGPTL3 ADGRF5 ADGRF5 PKD2 PKD2 ENG ENG TFAP2B TFAP2B EDN1 EDN1 APOE APOE STRA6 STRA6 FKBP10 FKBP10 APOB APOB CHD7 CHD7 NOTCH1 NOTCH1 JAG1 JAG1 BMPR1A BMPR1A COMP COMP BMPR2 BMPR2 ZMIZ1 ZMIZ1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TBX2T-box transcription factor 2. (697 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
PROX1Prospero homeobox 1. (737 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
FOXH1Forkhead box H1. (370 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (927 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
MYOCDMyocardin. (870 aa)
PRDM1PR/SET domain 1. (846 aa)
FOXF1Forkhead box F1. (379 aa)
ARID2AT-rich interaction domain 2. (1776 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (582 aa)
ACVRL1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (518 aa)
LDLRLow density lipoprotein receptor. (856 aa)
SRFSerum response factor. (507 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (515 aa)
ENSUAMP00000020431Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (76 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
GJA5Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
NF1Neurofibromin 1. (2845 aa)
LRP2LDL receptor related protein 2. (4684 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
HPGD15-hydroxyprostaglandin dehydrogenase. (172 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ANGPTL3Angiopoietin like 3. (425 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (897 aa)
ENGEndoglin. (650 aa)
TFAP2BTranscription factor AP-2 beta. (460 aa)
EDN1Endothelin 1. (202 aa)
APOEApolipoprotein E. (323 aa)
STRA6Stimulated by retinoic acid 6. (642 aa)
FKBP10Peptidylprolyl isomerase. (491 aa)
APOBApolipoprotein B. (4436 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2987 aa)
NOTCH1Notch receptor 1. (2547 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
ZMIZ1Zinc finger MIZ-type containing 1. (1044 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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