STRINGSTRING
HTR2B HTR2B ENSUAMP00000000600 ENSUAMP00000000600 MSX1 MSX1 MSI2 MSI2 TP53 TP53 TBX2 TBX2 PHF19 PHF19 NOG NOG ECE2 ECE2 LRP6 LRP6 ENSUAMP00000002165 ENSUAMP00000002165 GREM1 GREM1 PSMD11 PSMD11 ENSUAMP00000002924 ENSUAMP00000002924 CYP26C1 CYP26C1 ACVR1 ACVR1 SFRP1 SFRP1 XRCC5 XRCC5 ENSUAMP00000004593 ENSUAMP00000004593 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 ENSUAMP00000005111 ENSUAMP00000005111 PEF1 PEF1 ENSUAMP00000005615 ENSUAMP00000005615 ENSUAMP00000005739 ENSUAMP00000005739 ESR1 ESR1 EFNB1 EFNB1 SEMA3E SEMA3E SEMA6D SEMA6D HAND2 HAND2 SEMA3G SEMA3G TP63 TP63 LIF LIF CDK6 CDK6 RDH10 RDH10 ENSUAMP00000009188 ENSUAMP00000009188 HES1 HES1 GSC GSC SP7 SP7 MYOCD MYOCD ITGB1 ITGB1 ENSUAMP00000010461 ENSUAMP00000010461 PHACTR4 PHACTR4 SEMA6A SEMA6A RADIL RADIL SETD6 SETD6 PHOX2B PHOX2B ZFP36 ZFP36 EXT1 EXT1 ENSUAMP00000013328 ENSUAMP00000013328 MAPK1 MAPK1 ENSUAMP00000013636 ENSUAMP00000013636 ENSUAMP00000014216 ENSUAMP00000014216 FOXA1 FOXA1 ENSUAMP00000015361 ENSUAMP00000015361 ENSUAMP00000015416 ENSUAMP00000015416 SEMA7A SEMA7A SOX8 SOX8 BATF BATF ENSUAMP00000017162 ENSUAMP00000017162 SEMA4A SEMA4A ENSUAMP00000017830 ENSUAMP00000017830 HOXA7 HOXA7 WNT10A WNT10A SMAD4 SMAD4 SNAI2 SNAI2 KIT KIT SRF SRF SEMA4D SEMA4D TGFB2 TGFB2 NRP2 NRP2 ENSUAMP00000021252 ENSUAMP00000021252 GDNF GDNF CITED2 CITED2 KLHL12 KLHL12 SEMA4G SEMA4G PUM1 PUM1 ENSUAMP00000023294 ENSUAMP00000023294 SEMA4F SEMA4F SEMA6B SEMA6B ENSUAMP00000024987 ENSUAMP00000024987 FRZB FRZB WNT8A WNT8A SEMA4B SEMA4B SEMA3C SEMA3C ENSUAMP00000025721 ENSUAMP00000025721 JARID2 JARID2 ERCC2 ERCC2 SOX10 SOX10 SOX9 SOX9 DMRTA2 DMRTA2 SMO SMO NELFB NELFB SLC9A1 SLC9A1 HOXB4 HOXB4 ENSUAMP00000028596 ENSUAMP00000028596 PDCD6 PDCD6 EZH2 EZH2 UFL1 UFL1 PHF5A PHF5A ENSUAMP00000029322 ENSUAMP00000029322 BBS12 BBS12 MTF2 MTF2 MEF2C MEF2C FOXO4 FOXO4 ZIC3 ZIC3 KITLG KITLG ENSUAMP00000030435 ENSUAMP00000030435 EDN1 EDN1 ANXA6 ANXA6 SEMA4C SEMA4C CORO1C CORO1C RET RET MAPK3 MAPK3 ENSUAMP00000031755 ENSUAMP00000031755 GBX2 GBX2 NRTN NRTN FN1 FN1 TCOF1 TCOF1 ELL3 ELL3 SH2B3 SH2B3 SETD2 SETD2 HOXD4 HOXD4 MED1 MED1 NOTCH1 NOTCH1 SEMA3D SEMA3D HIF1A HIF1A JAG1 JAG1 OSR1 OSR1 LMBR1L LMBR1L HESX1 HESX1 SEMA6C SEMA6C BMPR1A BMPR1A ZNF281 ZNF281 FZD1 FZD1 ENSUAMP00000036515 ENSUAMP00000036515 SOX17 SOX17 METTL5 METTL5 NOLC1 NOLC1 EPOP EPOP SEMA3B SEMA3B SEMA3F SEMA3F
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HTR2B5-hydroxytryptamine receptor 2B. (480 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
MSX1Msh homeobox 1. (303 aa)
MSI2Musashi RNA binding protein 2. (324 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
TBX2T-box transcription factor 2. (697 aa)
PHF19PHD finger protein 19. (580 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ECE2Endothelin converting enzyme 2. (811 aa)
LRP6LDL receptor related protein 6. (1431 aa)
ENSUAMP00000002165Sema domain-containing protein; Belongs to the semaphorin family. (424 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (240 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (418 aa)
ENSUAMP00000002924Uncharacterized protein. (335 aa)
CYP26C1Cytochrome P450 family 26 subfamily C member 1; Belongs to the cytochrome P450 family. (522 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
XRCC5X-ray repair cross complementing 5. (501 aa)
ENSUAMP00000004593Uncharacterized protein. (64 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
ENSUAMP00000005111Aldedh domain-containing protein. (208 aa)
PEF1Penta-EF-hand domain containing 1. (289 aa)
ENSUAMP00000005615Uncharacterized protein. (177 aa)
ENSUAMP00000005739BTB domain-containing protein. (58 aa)
ESR1Estrogen receptor 1. (490 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (328 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (712 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
LIFLIF interleukin 6 family cytokine. (202 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (326 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
ENSUAMP00000009188Sema domain-containing protein; Belongs to the semaphorin family. (541 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
GSCGoosecoid homeobox. (256 aa)
SP7Sp7 transcription factor. (427 aa)
MYOCDMyocardin. (870 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
ENSUAMP00000010461BHLH domain-containing protein. (178 aa)
PHACTR4Phosphatase and actin regulator. (706 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (619 aa)
RADILRap associating with DIL domain. (1206 aa)
SETD6SET domain containing 6, protein lysine methyltransferase. (405 aa)
PHOX2BPaired like homeobox 2B. (289 aa)
ZFP36ZFP36 ring finger protein. (325 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
ENSUAMP00000013328Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (237 aa)
MAPK1Mitogen-activated protein kinase. (364 aa)
ENSUAMP00000013636Uncharacterized protein. (265 aa)
ENSUAMP00000014216Homeobox domain-containing protein. (315 aa)
FOXA1Forkhead box A1. (472 aa)
ENSUAMP00000015361CUB domain-containing protein. (131 aa)
ENSUAMP00000015416Uncharacterized protein. (479 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (663 aa)
SOX8SRY-box transcription factor 8. (449 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
ENSUAMP00000017162Uncharacterized protein. (137 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (755 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
HOXA7Homeobox A7. (235 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SNAI2Snail family transcriptional repressor 2. (230 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (999 aa)
SRFSerum response factor. (507 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (976 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
NRP2Neuropilin; Belongs to the neuropilin family. (851 aa)
ENSUAMP00000021252Uncharacterized protein. (409 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
KLHL12Kelch like family member 12. (568 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (822 aa)
PUM1PUM-HD domain-containing protein. (1082 aa)
ENSUAMP00000023294Uncharacterized protein. (67 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (762 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (764 aa)
ENSUAMP00000024987PHD-type domain-containing protein. (382 aa)
FRZBFrizzled related protein. (298 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (831 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
ENSUAMP00000025721Uncharacterized protein. (113 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1160 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (759 aa)
SOX10SRY-box transcription factor 10. (465 aa)
SOX9SRY-box transcription factor 9. (484 aa)
DMRTA2DMRT like family A2. (514 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
NELFBNegative elongation factor complex member B. (572 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (816 aa)
HOXB4Homeobox B4. (240 aa)
ENSUAMP00000028596IGv domain-containing protein. (133 aa)
PDCD6Programmed cell death 6. (189 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
UFL1UFM1 specific ligase 1. (516 aa)
PHF5APHD finger protein 5A. (85 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
BBS12Bardet-Biedl syndrome 12. (713 aa)
MTF2Metal response element binding transcription factor 2. (597 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
FOXO4Forkhead box O4. (506 aa)
ZIC3Uncharacterized protein. (466 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
ENSUAMP00000030435Fork-head domain-containing protein. (196 aa)
EDN1Endothelin 1. (202 aa)
ANXA6Annexin. (673 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (474 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1121 aa)
MAPK3Mitogen-activated protein kinase. (354 aa)
ENSUAMP00000031755Uncharacterized protein. (78 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
NRTNNeurturin. (157 aa)
FN1Fibronectin 1. (2385 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1383 aa)
ELL3Elongation factor for RNA polymerase II 3. (414 aa)
SH2B3SH2B adaptor protein 3. (374 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2520 aa)
HOXD4Homeobox D4. (187 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
NOTCH1Notch receptor 1. (2547 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
OSR1Odd-skipped related transcription factor 1. (267 aa)
LMBR1LLimb development membrane protein 1 like. (317 aa)
HESX1HESX homeobox 1. (185 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (949 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZNF281Zinc finger protein 281. (894 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
ENSUAMP00000036515Uncharacterized protein. (78 aa)
SOX17SRY-box transcription factor 17. (406 aa)
METTL5Methyltransferase like 5. (225 aa)
NOLC1Nucleolar and coiled-body phosphoprotein 1. (711 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (662 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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