STRINGSTRING
ADA ADA AKT2 AKT2 EPO EPO ENSUAMP00000036961 ENSUAMP00000036961 SLC37A4 SLC37A4 TSPO2 TSPO2 CCR4 CCR4 LPCAT3 LPCAT3 PRDM14 PRDM14 SPTA1 SPTA1 HIF1A HIF1A IL20RB IL20RB NOTCH1 NOTCH1 ENSUAMP00000034135 ENSUAMP00000034135 MED1 MED1 SH2B3 SH2B3 SIT1 SIT1 SOS1 SOS1 PTPN2 PTPN2 ATP5IF1 ATP5IF1 KLHL10 KLHL10 LRRC45 LRRC45 RIPK3 RIPK3 CARD11 CARD11 NKX2-3 NKX2-3 ENSUAMP00000031457 ENSUAMP00000031457 STAT5B STAT5B SART3 SART3 ENSUAMP00000031046 ENSUAMP00000031046 ENSUAMP00000030775 ENSUAMP00000030775 ENSUAMP00000030773 ENSUAMP00000030773 ASXL1 ASXL1 PPP2R3C PPP2R3C ENSUAMP00000030480 ENSUAMP00000030480 FOXA3 FOXA3 KITLG KITLG ARHGEF5 ARHGEF5 BCL2L11 BCL2L11 ENSUAMP00000029667 ENSUAMP00000029667 MEF2C MEF2C ADGRF5 ADGRF5 ZBTB7A ZBTB7A ADGRG1 ADGRG1 SH2B2 SH2B2 CSF1 CSF1 UFL1 UFL1 FOXP3 FOXP3 BMP4 BMP4 GATA3 GATA3 EZH2 EZH2 XKR8 XKR8 FLVCR1 FLVCR1 ENSUAMP00000028373 ENSUAMP00000028373 HOXB6 HOXB6 PTH PTH MTHFD1 MTHFD1 PDE4B PDE4B FADD FADD TRAF3IP2 TRAF3IP2 ENSUAMP00000027537 ENSUAMP00000027537 MAEA MAEA SMO SMO TNFAIP3 TNFAIP3 TRIM26 TRIM26 TRIM10 TRIM10 GAPT GAPT KMT2E KMT2E ENSUAMP00000026773 ENSUAMP00000026773 ENSUAMP00000026772 ENSUAMP00000026772 SOX9 SOX9 GBA GBA LGALS2 LGALS2 VPS54 VPS54 ERCC2 ERCC2 WDR48 WDR48 PKN1 PKN1 ENSUAMP00000025106 ENSUAMP00000025106 RC3H1 RC3H1 TCIRG1 TCIRG1 ENSUAMP00000024868 ENSUAMP00000024868 FH FH SP3 SP3 NF1 NF1 RCOR1 RCOR1 ILDR2 ILDR2 JAK3 JAK3 CX3CR1 CX3CR1 IREB2 IREB2 CITED2 CITED2 EMX1 EMX1 ENSUAMP00000022273 ENSUAMP00000022273 SMAD5 SMAD5 IL7 IL7 GPI GPI SLC46A2 SLC46A2 CDK5RAP3 CDK5RAP3 ENSUAMP00000021480 ENSUAMP00000021480 MFHAS1 MFHAS1 GPAM GPAM KRAS KRAS CASP3 CASP3 ENSUAMP00000020568 ENSUAMP00000020568 ENSUAMP00000020564 ENSUAMP00000020564 ZNHIT1 ZNHIT1 CCR7 CCR7 F2R F2R SRF SRF ENSUAMP00000019945 ENSUAMP00000019945 HMOX1 HMOX1 RC3H2 RC3H2 SKIL SKIL KIT KIT TNFRSF13B TNFRSF13B ITPKB ITPKB ENSUAMP00000018082 ENSUAMP00000018082 ADAR ADAR ENSUAMP00000017869 ENSUAMP00000017869 UBAP2L UBAP2L JMJD6 JMJD6 ENSUAMP00000016646 ENSUAMP00000016646 SLC39A3 SLC39A3 LYAR LYAR HSCB HSCB SOS2 SOS2 ENSUAMP00000015652 ENSUAMP00000015652 NCSTN NCSTN LGR4 LGR4 MPIG6B MPIG6B RB1 RB1 AHSP AHSP FOXN1 FOXN1 ENSUAMP00000014577 ENSUAMP00000014577 ENSUAMP00000014469 ENSUAMP00000014469 BCL6 BCL6 G6PD G6PD ENSUAMP00000014259 ENSUAMP00000014259 STAT5A STAT5A NLE1 NLE1 EXT1 EXT1 AXL AXL EPB42 EPB42 BCR BCR PKNOX1 PKNOX1 DNASE2 DNASE2 CORO1A CORO1A NCKAP1L NCKAP1L CARD9 CARD9 NBEA NBEA AKT3 AKT3 CCN3 CCN3 SLC4A1 SLC4A1 GATA1 GATA1 UBA5 UBA5 AKT1 AKT1 GCNT4 GCNT4 EPAS1 EPAS1 ENSUAMP00000010461 ENSUAMP00000010461 PTPN11 PTPN11 PPP3CB PPP3CB PLA2G10 PLA2G10 PRDX1 PRDX1 ENSUAMP00000010013 ENSUAMP00000010013 ABL1 ABL1 ARID4A ARID4A CEBPG CEBPG ENSUAMP00000009032 ENSUAMP00000009032 L3MBTL3 L3MBTL3 ENSUAMP00000008680 ENSUAMP00000008680 JAK2 JAK2 ARMCX1 ARMCX1 IKZF1 IKZF1 KCNQ1 KCNQ1 BAP1 BAP1 RASSF2 RASSF2 P2RX7 P2RX7 ENSUAMP00000006607 ENSUAMP00000006607 GLIS2 GLIS2 NCAPG2 NCAPG2 ANXA1 ANXA1 ALAS2 ALAS2 GPR183 GPR183 FSTL1 FSTL1 TNFRSF17 TNFRSF17 SASH3 SASH3 MERTK MERTK XIAP XIAP DMTN DMTN ZC3H8 ZC3H8 ENSUAMP00000002384 ENSUAMP00000002384 GPRASP1 GPRASP1 HSPA9 HSPA9 TNFSF13B TNFSF13B BAK1 BAK1 DYRK3 DYRK3 C15orf41 C15orf41
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ADAAdenosine deaminase. (385 aa)
AKT2Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)
EPOErythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. (192 aa)
ENSUAMP00000036961Uncharacterized protein. (86 aa)
SLC37A4Solute carrier family 37 member 4. (429 aa)
TSPO2Translocator protein 2. (174 aa)
CCR4C-C motif chemokine receptor 4; Belongs to the G-protein coupled receptor 1 family. (360 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (477 aa)
PRDM14PR/SET domain 14. (566 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2420 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (823 aa)
IL20RBInterleukin 20 receptor subunit beta. (283 aa)
NOTCH1Notch receptor 1. (2547 aa)
ENSUAMP00000034135Uncharacterized protein. (131 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
SH2B3SH2B adaptor protein 3. (374 aa)
SIT1Signaling threshold regulating transmembrane adaptor 1. (173 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1232 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (391 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (103 aa)
KLHL10Kelch like family member 10. (608 aa)
LRRC45Leucine rich repeat containing 45. (670 aa)
RIPK3Receptor interacting serine/threonine kinase 3; Belongs to the protein kinase superfamily. (451 aa)
CARD11Caspase recruitment domain family member 11. (1123 aa)
NKX2-3NK2 homeobox 3. (318 aa)
ENSUAMP00000031457Uncharacterized protein; Belongs to the mitochondrial carrier (TC 2.A.29) family. (164 aa)
STAT5BSignal transducer and activator of transcription. (784 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (964 aa)
ENSUAMP00000031046Uncharacterized protein. (68 aa)
ENSUAMP00000030775Uncharacterized protein. (128 aa)
ENSUAMP00000030773Uncharacterized protein. (87 aa)
ASXL1ASXL transcriptional regulator 1. (1306 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (450 aa)
ENSUAMP00000030480HARE-HTH domain-containing protein. (88 aa)
FOXA3Forkhead box A3. (350 aa)
KITLGKit ligand; Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. Belongs to the SCF family. (274 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1579 aa)
BCL2L11BCL2 like 11. (140 aa)
ENSUAMP00000029667Uncharacterized protein. (146 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ADGRF5Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. (1346 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (529 aa)
ADGRG1Adhesion G protein-coupled receptor G1; Belongs to the G-protein coupled receptor 2 family. (687 aa)
SH2B2SH2B adaptor protein 2. (404 aa)
CSF1Colony stimulating factor 1. (518 aa)
UFL1UFM1 specific ligase 1. (516 aa)
FOXP3Forkhead box P3. (427 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
GATA3GATA binding protein 3. (444 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (746 aa)
XKR8XK-related protein. (399 aa)
FLVCR1Feline leukemia virus subgroup C cellular receptor 1. (545 aa)
ENSUAMP00000028373Uncharacterized protein. (68 aa)
HOXB6Homeobox B6. (224 aa)
PTHParathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (115 aa)
MTHFD1Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (992 aa)
PDE4BPhosphodiesterase. (682 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (220 aa)
TRAF3IP2TRAF3 interacting protein 2. (455 aa)
ENSUAMP00000027537SEFIR domain-containing protein. (109 aa)
MAEAMacrophage erythroblast attacher. (434 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
TNFAIP3TNF alpha induced protein 3. (790 aa)
TRIM26Tripartite motif containing 26. (514 aa)
TRIM10Tripartite motif containing 10. (481 aa)
GAPTGRB2 binding adaptor protein, transmembrane. (156 aa)
KMT2ELysine methyltransferase 2E. (1850 aa)
ENSUAMP00000026773Uncharacterized protein. (179 aa)
ENSUAMP00000026772ETS domain-containing protein. (163 aa)
SOX9SRY-box transcription factor 9. (484 aa)
GBAGlucosylceramidase. (540 aa)
LGALS2Galectin. (132 aa)
VPS54VPS54 subunit of GARP complex. (965 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (759 aa)
WDR48WD repeat domain 48. (626 aa)
PKN1Protein kinase domain-containing protein. (739 aa)
ENSUAMP00000025106Uncharacterized protein. (78 aa)
RC3H1Ring finger and CCCH-type domains 1. (1125 aa)
TCIRG1V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (828 aa)
ENSUAMP00000024868Uncharacterized protein. (79 aa)
FHFumarate hydratase. (493 aa)
SP3Sp3 transcription factor. (780 aa)
NF1Neurofibromin 1. (2845 aa)
RCOR1REST corepressor 1. (397 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (418 aa)
JAK3Tyrosine-protein kinase. (1015 aa)
CX3CR1C-X3-C motif chemokine receptor 1; Belongs to the G-protein coupled receptor 1 family. (356 aa)
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (906 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
EMX1Empty spiracles homeobox 1. (294 aa)
ENSUAMP00000022273AGC-kinase C-terminal domain-containing protein. (60 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
IL7Interleukin 7. (152 aa)
GPIGlucose-6-phosphate isomerase; Belongs to the GPI family. (558 aa)
SLC46A2Solute carrier family 46 member 2. (484 aa)
CDK5RAP3CDK5 regulatory subunit associated protein 3. (504 aa)
ENSUAMP00000021480Uncharacterized protein. (135 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1042 aa)
GPAMGlycerol-3-phosphate acyltransferase 1, mitochondrial. (828 aa)
KRASKRAS proto-oncogene, GTPase. (188 aa)
CASP3Caspase 3; Belongs to the peptidase C14A family. (266 aa)
ENSUAMP00000020568DNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (181 aa)
ENSUAMP00000020564HHH_8 domain-containing protein. (107 aa)
ZNHIT1Zinc finger HIT-type containing 1. (154 aa)
CCR7C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (373 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (427 aa)
SRFSerum response factor. (507 aa)
ENSUAMP00000019945Uncharacterized protein. (237 aa)
HMOX1Heme oxygenase 1. (288 aa)
RC3H2Ring finger and CCCH-type domains 2. (1189 aa)
SKILSKI like proto-oncogene. (684 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (999 aa)
TNFRSF13BTNF receptor superfamily member 13B. (258 aa)
ITPKBKinase; Belongs to the inositol phosphokinase (IPK) family. (936 aa)
ENSUAMP00000018082Uncharacterized protein. (249 aa)
ADARAdenosine deaminase RNA specific. (1148 aa)
ENSUAMP00000017869Uncharacterized protein. (53 aa)
UBAP2LUbiquitin associated protein 2 like. (1104 aa)
JMJD6Jumonji domain containing 6, arginine demethylase and lysine hydroxylase. (403 aa)
ENSUAMP00000016646Uncharacterized protein. (167 aa)
SLC39A3Solute carrier family 39 member 3. (314 aa)
LYARLy1 antibody reactive. (351 aa)
HSCBHscB mitochondrial iron-sulfur cluster cochaperone. (235 aa)
SOS2SOS Ras/Rho guanine nucleotide exchange factor 2. (1306 aa)
ENSUAMP00000015652Aldolase_II domain-containing protein. (400 aa)
NCSTNNicastrin. (709 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (971 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b. (255 aa)
RB1RB transcriptional corepressor 1. (870 aa)
AHSPAlpha hemoglobin stabilizing protein. (99 aa)
FOXN1Forkhead box N1. (634 aa)
ENSUAMP00000014577Uncharacterized protein. (368 aa)
ENSUAMP00000014469Ig-like domain-containing protein. (209 aa)
BCL6BCL6 transcription repressor. (706 aa)
G6PDGlucose-6-phosphate 1-dehydrogenase; Catalyzes the rate-limiting step of the oxidative pentose- phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. (572 aa)
ENSUAMP0000001425940S ribosomal protein S24; Belongs to the eukaryotic ribosomal protein eS24 family. (131 aa)
STAT5ASignal transducer and activator of transcription. (797 aa)
NLE1Notchless homolog 1. (477 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
AXLAXL receptor tyrosine kinase. (898 aa)
EPB42Erythrocyte membrane protein band 4.2. (634 aa)
BCRBCR activator of RhoGEF and GTPase. (1100 aa)
PKNOX1PBX/knotted 1 homeobox 1. (403 aa)
DNASE2Deoxyribonuclease 2, lysosomal. (408 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
NCKAP1LNCK associated protein 1 like. (1115 aa)
CARD9Caspase recruitment domain family member 9. (566 aa)
NBEADUF4704 domain-containing protein. (1862 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CCN3Cellular communication network factor 3. (353 aa)
SLC4A1Anion exchange protein. (853 aa)
GATA1GATA binding protein 1. (413 aa)
UBA5Ubiquitin like modifier activating enzyme 5. (432 aa)
AKT1Non-specific serine/threonine protein kinase. (572 aa)
GCNT4Glucosaminyl (N-acetyl) transferase 4. (454 aa)
EPAS1Endothelial PAS domain protein 1. (863 aa)
ENSUAMP00000010461BHLH domain-containing protein. (178 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
PLA2G10Phospholipase A(2). (157 aa)
PRDX1Peroxiredoxin 1. (185 aa)
ENSUAMP00000010013Uncharacterized protein. (73 aa)
ABL1Tyrosine-protein kinase. (1138 aa)
ARID4AAT-rich interaction domain 4A. (1250 aa)
CEBPGCCAAT enhancer binding protein gamma. (147 aa)
ENSUAMP00000009032Uncharacterized protein. (282 aa)
L3MBTL3L3MBTL histone methyl-lysine binding protein 3. (780 aa)
ENSUAMP00000008680Uncharacterized protein. (251 aa)
JAK2Tyrosine-protein kinase. (1132 aa)
ARMCX1Armadillo repeat containing X-linked 1. (458 aa)
IKZF1IKAROS family zinc finger 1. (347 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (672 aa)
BAP1Ubiquitin carboxyl-terminal hydrolase. (678 aa)
RASSF2Ras association domain family member 2. (361 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (578 aa)
ENSUAMP00000006607Uncharacterized protein. (215 aa)
GLIS2GLIS family zinc finger 2. (524 aa)
NCAPG2Non-SMC condensin II complex subunit G2. (867 aa)
ANXA1Annexin. (345 aa)
ALAS25-aminolevulinate synthase. (587 aa)
GPR183G protein-coupled receptor 183; Belongs to the G-protein coupled receptor 1 family. (357 aa)
FSTL1Follistatin like 1. (307 aa)
TNFRSF17TNF receptor superfamily member 17. (178 aa)
SASH3SAM and SH3 domain containing 3. (369 aa)
MERTKMER proto-oncogene, tyrosine kinase. (818 aa)
XIAPX-linked inhibitor of apoptosis. (514 aa)
DMTNDematin actin binding protein. (396 aa)
ZC3H8Zinc finger CCCH-type containing 8. (307 aa)
ENSUAMP00000002384Uncharacterized protein. (549 aa)
GPRASP1G protein-coupled receptor associated sorting protein 1. (1390 aa)
HSPA9Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (678 aa)
TNFSF13BTNF superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
DYRK3Dual specificity tyrosine phosphorylation regulated kinase 3. (551 aa)
C15orf41Chromosome 15 open reading frame 41. (160 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (14%) [HD]