STRINGSTRING
DLL3 DLL3 ENSUAMP00000001571 ENSUAMP00000001571 TP53 TP53 SYNGAP1 SYNGAP1 ENSUAMP00000000274 ENSUAMP00000000274 ENSUAMP00000000316 ENSUAMP00000000316 ENSUAMP00000000397 ENSUAMP00000000397 CTDSP1 CTDSP1 SEMA3F SEMA3F SEMA3B SEMA3B IFRD2 IFRD2 TREML1 TREML1 TREM2 TREM2 HOOK3 HOOK3 NR2E1 NR2E1 RAPGEF2 RAPGEF2 BMPR1A BMPR1A SEMA6C SEMA6C WNT3 WNT3 SORL1 SORL1 APPL2 APPL2 F2 F2 SEMA3D SEMA3D NOTCH1 NOTCH1 ENSUAMP00000032923 ENSUAMP00000032923 SEMA4C SEMA4C CDK5 CDK5 LRP4 LRP4 TLX2 TLX2 NKX6-2 NKX6-2 PTN PTN GPR37L1 GPR37L1 GORASP1 GORASP1 SEMA3C SEMA3C ENSUAMP00000025354 ENSUAMP00000025354 SEMA4B SEMA4B RTN4 RTN4 ATOH7 ATOH7 SEMA6B SEMA6B ENSUAMP00000024489 ENSUAMP00000024489 SEMA4F SEMA4F NF1 NF1 YWHAH YWHAH B2M B2M ENSUAMP00000023517 ENSUAMP00000023517 SEMA4G SEMA4G ENSUAMP00000023172 ENSUAMP00000023172 LHX2 LHX2 ULK1 ULK1 ENSUAMP00000021600 ENSUAMP00000021600 ENSUAMP00000021252 ENSUAMP00000021252 SEMA4D SEMA4D LDLR LDLR NF2 NF2 NR1D1 NR1D1 ATOH1 ATOH1 PTPRS PTPRS THY1 THY1 SEMA4A SEMA4A TRIM11 TRIM11 DIP2B DIP2B SEMA7A SEMA7A RB1 RB1 BRINP1 BRINP1 GDI1 GDI1 PLXNA3 PLXNA3 PCM1 PCM1 ENSUAMP00000013482 ENSUAMP00000013482 RTN4R RTN4R WNT3A WNT3A SEMA6A SEMA6A RYK RYK HES1 HES1 DLX2 DLX2 DLX1 DLX1 ENSUAMP00000009188 ENSUAMP00000009188 NFATC4 NFATC4 PPP3CA PPP3CA DPYSL5 DPYSL5 SEMA3G SEMA3G ENSUAMP00000006676 ENSUAMP00000006676 SEMA6D SEMA6D SEMA3E SEMA3E EFNB3 EFNB3 NKX6-1 NKX6-1 ENSUAMP00000002924 ENSUAMP00000002924 SPART SPART TMEM98 TMEM98 PROX1 PROX1 ENSUAMP00000002165 ENSUAMP00000002165 NOG NOG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DLL3Delta like canonical Notch ligand 3. (565 aa)
ENSUAMP00000001571Uncharacterized protein. (289 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1415 aa)
ENSUAMP00000000274J domain-containing protein. (200 aa)
ENSUAMP00000000316Homeobox domain-containing protein. (280 aa)
ENSUAMP00000000397Paired domain-containing protein. (216 aa)
CTDSP1CTD small phosphatase 1. (307 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (662 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (773 aa)
IFRD2Interferon related developmental regulator 2. (441 aa)
TREML1Triggering receptor expressed on myeloid cells like 1. (311 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (230 aa)
HOOK3Hook microtubule tethering protein 3. (500 aa)
NR2E1Nuclear receptor subfamily 2 group E member 1. (385 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1516 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (949 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
SORL1Sortilin related receptor 1. (2210 aa)
APPL2Adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2. (652 aa)
F2Coagulation factor II, thrombin; Belongs to the peptidase S1 family. (602 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (777 aa)
NOTCH1Notch receptor 1. (2547 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (833 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
LRP4LDL receptor related protein 4. (1852 aa)
TLX2T cell leukemia homeobox 2. (284 aa)
NKX6-2NK6 homeobox 2. (269 aa)
PTNPleiotrophin. (218 aa)
GPR37L1G protein-coupled receptor 37 like 1. (480 aa)
GORASP1Golgi reassembly stacking protein 1. (447 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (750 aa)
ENSUAMP00000025354HMG box domain-containing protein. (302 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (831 aa)
RTN4Reticulon. (951 aa)
ATOH7Atonal bHLH transcription factor 7. (149 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (764 aa)
ENSUAMP00000024489Uncharacterized protein. (451 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (762 aa)
NF1Neurofibromin 1. (2845 aa)
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)
B2MBeta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. (118 aa)
ENSUAMP00000023517Laminin N-terminal domain-containing protein. (378 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (822 aa)
ENSUAMP00000023172Uncharacterized protein. (275 aa)
LHX2LIM homeobox 2. (392 aa)
ULK1Unc-51 like autophagy activating kinase 1. (974 aa)
ENSUAMP00000021600Uncharacterized protein; Belongs to the metallothionein superfamily. Type 1 family. (203 aa)
ENSUAMP00000021252Uncharacterized protein. (409 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (976 aa)
LDLRLow density lipoprotein receptor. (856 aa)
NF2Neurofibromin 2. (596 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (600 aa)
ATOH1Atonal bHLH transcription factor 1. (356 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1910 aa)
THY1Thy-1 cell surface antigen. (161 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (755 aa)
TRIM11Tripartite motif containing 11. (468 aa)
DIP2BDisco interacting protein 2 homolog B. (1554 aa)
SEMA7ASemaphorin 7A (John Milton Hagen blood group); Belongs to the semaphorin family. (663 aa)
RB1RB transcriptional corepressor 1. (870 aa)
BRINP1BMP/retinoic acid inducible neural specific 1. (724 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (450 aa)
PLXNA3Plexin A3. (1794 aa)
PCM1Pericentriolar material 1. (2123 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
RTN4RReticulon 4 receptor. (472 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (619 aa)
RYKReceptor like tyrosine kinase. (599 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
DLX2Distal-less homeobox 2. (333 aa)
DLX1Distal-less homeobox 1. (255 aa)
ENSUAMP00000009188Sema domain-containing protein; Belongs to the semaphorin family. (541 aa)
NFATC4Nuclear factor of activated T cells 4. (911 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
DPYSL5Dihydropyrimidinase like 5. (522 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (712 aa)
ENSUAMP00000006676Ig-like domain-containing protein. (136 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1086 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (775 aa)
EFNB3Ephrin B3. (180 aa)
NKX6-1NK6 homeobox 1. (366 aa)
ENSUAMP00000002924Uncharacterized protein. (335 aa)
SPARTSpartin. (672 aa)
TMEM98Transmembrane protein 98. (226 aa)
PROX1Prospero homeobox 1. (737 aa)
ENSUAMP00000002165Sema domain-containing protein; Belongs to the semaphorin family. (424 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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