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IREB2 IREB2 ERCC2 ERCC2 ACO1 ACO1 MOCS1 MOCS1 ACO2 ACO2 NTHL1 NTHL1 DPH2 DPH2 ENSUAMP00000034778 ENSUAMP00000034778 ENSUAMP00000034635 ENSUAMP00000034635 ETFDH ETFDH ENSUAMP00000033767 ENSUAMP00000033767 NDUFS2 NDUFS2 ENSUAMP00000032975 ENSUAMP00000032975 SDHB SDHB RSAD2 RSAD2 LIAS LIAS ENSUAMP00000001416 ENSUAMP00000001416 ISCA2 ISCA2 ENSUAMP00000002850 ENSUAMP00000002850 NUBP1 NUBP1 SERP1 SERP1 NFU1 NFU1 ENSUAMP00000011715 ENSUAMP00000011715 SERP2 SERP2 ENSUAMP00000011742 ENSUAMP00000011742 ENSUAMP00000011763 ENSUAMP00000011763 INO80D INO80D ENSUAMP00000012006 ENSUAMP00000012006 NDUFV1 NDUFV1 ENSUAMP00000012629 ENSUAMP00000012629 ENSUAMP00000012774 ENSUAMP00000012774 RSAD1 RSAD1 ENSUAMP00000013559 ENSUAMP00000013559 CIAO3 CIAO3 ENSUAMP00000016108 ENSUAMP00000016108 NUBP2 NUBP2 ELP3 ELP3 ENSUAMP00000018500 ENSUAMP00000018500 NDUFS7 NDUFS7 POLD1 POLD1 ENSUAMP00000022576 ENSUAMP00000022576 ENSUAMP00000022690 ENSUAMP00000022690 ENSUAMP00000024903 ENSUAMP00000024903
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
IREB2Iron responsive element binding protein 2; Belongs to the aconitase/IPM isomerase family. (906 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (759 aa)
ACO1Aconitase 1; Belongs to the aconitase/IPM isomerase family. (889 aa)
MOCS1Molybdenum cofactor synthesis 1. (633 aa)
ACO2Aconitate hydratase, mitochondrial; Belongs to the aconitase/IPM isomerase family. (799 aa)
NTHL1Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (323 aa)
DPH22-(3-amino-3-carboxypropyl)histidine synthase subunit 2; Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. (489 aa)
ENSUAMP00000034778Uncharacterized protein. (361 aa)
ENSUAMP00000034635MTTase N-terminal domain-containing protein. (103 aa)
ETFDHElectron transfer flavoprotein-ubiquinone oxidoreductase; Accepts electrons from ETF and reduces ubiquinone. (617 aa)
ENSUAMP00000033767Uncharacterized protein. (60 aa)
NDUFS2NADH:ubiquinone oxidoreductase core subunit S2; Belongs to the complex I 49 kDa subunit family. (533 aa)
ENSUAMP00000032975Uncharacterized protein. (197 aa)
SDHBSuccinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (254 aa)
RSAD2Radical S-adenosyl methionine domain containing 2. (363 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (373 aa)
ENSUAMP00000001416Flavodoxin-like domain-containing protein. (444 aa)
ISCA2Iron-sulfur cluster assembly 2. (155 aa)
ENSUAMP00000002850Methyltransf_11 domain-containing protein. (179 aa)
NUBP1Cytosolic Fe-S cluster assembly factor NUBP1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (320 aa)
SERP1Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (66 aa)
NFU1NFU1 iron-sulfur cluster scaffold. (253 aa)
ENSUAMP00000011715DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (404 aa)
SERP2Stress-associated endoplasmic reticulum protein; May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. Belongs to the RAMP4 family. (77 aa)
ENSUAMP00000011742DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (667 aa)
ENSUAMP00000011763DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (295 aa)
INO80DINO80 complex subunit D. (1030 aa)
ENSUAMP00000012006Uncharacterized protein. (255 aa)
NDUFV1NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. (464 aa)
ENSUAMP00000012629Uncharacterized protein. (211 aa)
ENSUAMP00000012774Methyltransf_11 domain-containing protein. (191 aa)
RSAD1Radical S-adenosyl methionine domain-containing protein; May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen- III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L- methionine; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (442 aa)
ENSUAMP00000013559Uncharacterized protein. (126 aa)
CIAO3Cytosolic iron-sulfur assembly component 3; Belongs to the NARF family. (546 aa)
ENSUAMP00000016108Uncharacterized protein. (92 aa)
NUBP2Nucleotide binding protein 2. (311 aa)
ELP3Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (524 aa)
ENSUAMP00000018500Fer4_20 domain-containing protein. (166 aa)
NDUFS7NADH:ubiquinone oxidoreductase core subunit S7; Belongs to the complex I 20 kDa subunit family. (216 aa)
POLD1DNA polymerase. (1109 aa)
ENSUAMP00000022576Adenine DNA glycosylase; Adenine glycosylase active on G-A mispairs. (541 aa)
ENSUAMP00000022690Uncharacterized protein. (94 aa)
ENSUAMP00000024903Uncharacterized protein. (210 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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