(21 nodes) Misfolded protein binding network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DERL2	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
	DNAJC3	DnaJ heat shock protein family (Hsp40) member C3. (504 aa)
	DNAJB9	DnaJ heat shock protein family (Hsp40) member B9. (222 aa)
	ENSUAMP00000001165	Uncharacterized protein. (96 aa)
	HSPA9	Heat shock protein family A (Hsp70) member 9; Belongs to the heat shock protein 70 family. (678 aa)
	CLUL1	Clusterin; Belongs to the clusterin family. (464 aa)
	SDF2	Stromal cell derived factor 2. (211 aa)
	HSPA14	Heat shock protein family A (Hsp70) member 14; Belongs to the heat shock protein 70 family. (509 aa)
	DNAJC10	DnaJ heat shock protein family (Hsp40) member C10. (816 aa)
	DERL3	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (231 aa)
	CLU	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. (446 aa)
	BAG6	BCL2 associated athanogene 6. (1164 aa)
	HSPA5	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family. (654 aa)
	TOR1A	Torsin. (332 aa)
	ENSUAMP00000025023	ANK_REP_REGION domain-containing protein. (285 aa)
	EDEM1	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family. (699 aa)
	SDF2L1	Stromal cell derived factor 2 like 1. (221 aa)
	DERL1	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (251 aa)
	HSPA8	Uncharacterized protein; Belongs to the heat shock protein 70 family. (646 aa)
	ENSUAMP00000031983	Uncharacterized protein; Belongs to the heat shock protein 70 family. (653 aa)
	HSPA13	Heat shock protein family A (Hsp70) member 13. (372 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLU	HSPA5	ENSUAMP00000014766	ENSUAMP00000018212	Clusterin; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.455
DERL1	DERL2	ENSUAMP00000027926	ENSUAMP00000015174	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.985
DERL1	DERL3	ENSUAMP00000027926	ENSUAMP00000013446	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.985
DERL1	DNAJB9	ENSUAMP00000027926	ENSUAMP00000000569	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	DnaJ heat shock protein family (Hsp40) member B9.	0.415
DERL1	DNAJC10	ENSUAMP00000027926	ENSUAMP00000008035	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	DnaJ heat shock protein family (Hsp40) member C10.	0.571
DERL1	DNAJC3	ENSUAMP00000027926	ENSUAMP00000000077	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	DnaJ heat shock protein family (Hsp40) member C3.	0.582
DERL1	EDEM1	ENSUAMP00000027926	ENSUAMP00000027605	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.680
DERL1	ENSUAMP00000025023	ENSUAMP00000027926	ENSUAMP00000025023	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ANK_REP_REGION domain-containing protein.	0.654
DERL1	HSPA5	ENSUAMP00000027926	ENSUAMP00000018212	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.950
DERL2	DERL1	ENSUAMP00000015174	ENSUAMP00000027926	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.985
DERL2	DERL3	ENSUAMP00000015174	ENSUAMP00000013446	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.957
DERL2	EDEM1	ENSUAMP00000015174	ENSUAMP00000027605	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.674
DERL2	ENSUAMP00000025023	ENSUAMP00000015174	ENSUAMP00000025023	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ANK_REP_REGION domain-containing protein.	0.654
DERL2	HSPA5	ENSUAMP00000015174	ENSUAMP00000018212	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.723
DERL3	DERL1	ENSUAMP00000013446	ENSUAMP00000027926	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.985
DERL3	DERL2	ENSUAMP00000013446	ENSUAMP00000015174	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	0.957
DERL3	DNAJC3	ENSUAMP00000013446	ENSUAMP00000000077	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	DnaJ heat shock protein family (Hsp40) member C3.	0.438
DERL3	EDEM1	ENSUAMP00000013446	ENSUAMP00000027605	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.	0.553
DERL3	ENSUAMP00000025023	ENSUAMP00000013446	ENSUAMP00000025023	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	ANK_REP_REGION domain-containing protein.	0.654
DERL3	HSPA5	ENSUAMP00000013446	ENSUAMP00000018212	Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.	Heat shock protein family A (Hsp70) member 5; Belongs to the heat shock protein 70 family.	0.723