STRINGSTRING
CACNA1S CACNA1S ENSUAMP00000000600 ENSUAMP00000000600 MYOZ2 MYOZ2 MYOF MYOF PROX1 PROX1 TBX5 TBX5 CSRP2 CSRP2 ENSUAMP00000002781 ENSUAMP00000002781 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 ACTC1 ACTC1 ENSUAMP00000004823 ENSUAMP00000004823 ENSUAMP00000005311 ENSUAMP00000005311 CSRP1 CSRP1 TNNT2 TNNT2 ENSUAMP00000005541 ENSUAMP00000005541 TMOD1 TMOD1 MYORG MYORG C9orf24 C9orf24 ENSUAMP00000006515 ENSUAMP00000006515 CAPN3 CAPN3 ENSUAMP00000006638 ENSUAMP00000006638 CSRP3 CSRP3 ENSUAMP00000007554 ENSUAMP00000007554 SYPL2 SYPL2 LOX LOX ALPK3 ALPK3 PPP3CA PPP3CA NFATC4 NFATC4 CAV2 CAV2 PRKAR1B PRKAR1B PTCD2 PTCD2 NRAP NRAP HES1 HES1 CFL2 CFL2 SDC1 SDC1 KRT19 KRT19 ITGB1 ITGB1 WDR1 WDR1 KLHL40 KLHL40 PPP3CB PPP3CB MEGF10 MEGF10 ENSUAMP00000010858 ENSUAMP00000010858 ENSUAMP00000010867 ENSUAMP00000010867 MYLK3 MYLK3 ENSUAMP00000011392 ENSUAMP00000011392 TCAP TCAP WFIKKN2 WFIKKN2 BIN1 BIN1 ADPRH ADPRH BVES BVES ENSUAMP00000012729 ENSUAMP00000012729 TMEM182 TMEM182 FLII FLII ACTN1 ACTN1 ENSUAMP00000013482 ENSUAMP00000013482 ENSUAMP00000013919 ENSUAMP00000013919 NKX2-6 NKX2-6 RIPOR2 RIPOR2 ENSUAMP00000015680 ENSUAMP00000015680 MAML1 MAML1 BMP10 BMP10 KEL KEL RAMP2 RAMP2 LMNA LMNA ENSUAMP00000017462 ENSUAMP00000017462 ENSUAMP00000017830 ENSUAMP00000017830 ACTA2 ACTA2 ENSUAMP00000018124 ENSUAMP00000018124 CHRNB1 CHRNB1 PDGFRA PDGFRA ACTA1 ACTA1 MYOZ1 MYOZ1 SYNPO2L SYNPO2L MTOR MTOR SRF SRF ENSUAMP00000020340 ENSUAMP00000020340 ENSUAMP00000021241 ENSUAMP00000021241 ENSUAMP00000021250 ENSUAMP00000021250 SIX4 SIX4 TNNT1 TNNT1 LRRC10B LRRC10B ACTN2 ACTN2 MEF2A MEF2A LMOD3 LMOD3 ENSUAMP00000023660 ENSUAMP00000023660 ACTG2 ACTG2 KLHL41 KLHL41 ENSUAMP00000024290 ENSUAMP00000024290 ATG5 ATG5 MYPN MYPN WFIKKN1 WFIKKN1 ENSUAMP00000025619 ENSUAMP00000025619 LMOD1 LMOD1 ENSUAMP00000026324 ENSUAMP00000026324 ENSUAMP00000026326 ENSUAMP00000026326 TNNT3 TNNT3 R3HDM2 R3HDM2 STAC3 STAC3 SMO SMO LMOD2 LMOD2 TMOD2 TMOD2 TMOD3 TMOD3 FLNC FLNC DYSF DYSF HNRNPU HNRNPU ENG ENG CAV3 CAV3 ENSUAMP00000032138 ENSUAMP00000032138 HOMER1 HOMER1 ASB2 ASB2 R3HDM1 R3HDM1 BIN3 BIN3 ENSUAMP00000033199 ENSUAMP00000033199 CXADR CXADR MYOM2 MYOM2 PRKAR1A PRKAR1A ENSUAMP00000033749 ENSUAMP00000033749 ENSUAMP00000033750 ENSUAMP00000033750 FHL2 FHL2 NOTCH1 NOTCH1 NEB NEB ENSUAMP00000034792 ENSUAMP00000034792 WNT10B WNT10B TMOD4 TMOD4 LDB3 LDB3 BMPR1A BMPR1A ZMPSTE24 ZMPSTE24 COMP COMP PGM5 PGM5 MYOD1 MYOD1 ENSUAMP00000037129 ENSUAMP00000037129
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CACNA1SVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (1872 aa)
ENSUAMP00000000600Uncharacterized protein. (130 aa)
MYOZ2Myozenin 2. (264 aa)
MYOFMyoferlin. (2096 aa)
PROX1Prospero homeobox 1. (737 aa)
TBX5T-box transcription factor 5. (517 aa)
CSRP2Cysteine and glycine rich protein 2. (272 aa)
ENSUAMP00000002781calpain_III domain-containing protein. (81 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
ACTC1Actin alpha cardiac muscle 1. (381 aa)
ENSUAMP00000004823SH3 domain-containing protein. (506 aa)
ENSUAMP00000005311Uncharacterized protein. (1199 aa)
CSRP1Cysteine and glycine rich protein 1. (200 aa)
TNNT2Troponin T2, cardiac type. (215 aa)
ENSUAMP00000005541P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (437 aa)
TMOD1Tropomodulin 1. (359 aa)
MYORGMyogenesis regulating glycosidase (putative); Belongs to the glycosyl hydrolase 31 family. (714 aa)
C9orf24Chromosome 9 open reading frame 24. (261 aa)
ENSUAMP00000006515Uncharacterized protein. (190 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (750 aa)
ENSUAMP00000006638ZZ-type domain-containing protein. (342 aa)
CSRP3Cysteine and glycine rich protein 3. (194 aa)
ENSUAMP00000007554Uncharacterized protein. (354 aa)
SYPL2Synaptophysin like 2. (363 aa)
LOXLysyl oxidase. (414 aa)
ALPK3Alpha kinase 3. (1619 aa)
PPP3CASerine/threonine-protein phosphatase. (317 aa)
NFATC4Nuclear factor of activated T cells 4. (911 aa)
CAV2Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (162 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (377 aa)
PTCD2Pentatricopeptide repeat domain 2. (427 aa)
NRAPNebulin related anchoring protein. (1729 aa)
HES1Hes family bHLH transcription factor 1. (259 aa)
CFL2Cofilin 2; Belongs to the actin-binding proteins ADF family. (148 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (301 aa)
KRT19Keratin 19; Belongs to the intermediate filament family. (407 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (771 aa)
WDR1WD repeat domain 1. (610 aa)
KLHL40Kelch like family member 40. (623 aa)
PPP3CBSerine/threonine-protein phosphatase. (479 aa)
MEGF10Multiple EGF like domains 10. (1045 aa)
ENSUAMP00000010858Myosin_tail_1 domain-containing protein. (890 aa)
ENSUAMP00000010867Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (207 aa)
MYLK3Myosin light chain kinase 3. (791 aa)
ENSUAMP00000011392Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (762 aa)
TCAPTitin-cap. (167 aa)
WFIKKN2WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2. (573 aa)
BIN1Bridging integrator 1. (686 aa)
ADPRHADP-ribosylarginine hydrolase. (362 aa)
BVESBlood vessel epicardial substance. (323 aa)
ENSUAMP00000012729RHD domain-containing protein. (481 aa)
TMEM182Transmembrane protein 182. (210 aa)
FLIIFLII actin remodeling protein. (1273 aa)
ACTN1Actinin alpha 1. (914 aa)
ENSUAMP00000013482Uncharacterized protein. (91 aa)
ENSUAMP00000013919Uncharacterized protein. (497 aa)
NKX2-6NK2 homeobox 6. (268 aa)
RIPOR2PL48 domain-containing protein. (1063 aa)
ENSUAMP00000015680Uncharacterized protein. (92 aa)
MAML1Mastermind like transcriptional coactivator 1. (933 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
KELKell metallo-endopeptidase (Kell blood group). (716 aa)
RAMP2Receptor activity modifying protein 2. (100 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (671 aa)
ENSUAMP00000017462Uncharacterized protein. (88 aa)
ENSUAMP00000017830Uncharacterized protein. (157 aa)
ACTA2Actin alpha 2, smooth muscle. (377 aa)
ENSUAMP00000018124Uncharacterized protein. (249 aa)
CHRNB1Cholinergic receptor nicotinic beta 1 subunit. (576 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
ACTA1Actin alpha 1, skeletal muscle. (377 aa)
MYOZ1Myozenin 1. (299 aa)
SYNPO2LSynaptopodin 2 like. (970 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
SRFSerum response factor. (507 aa)
ENSUAMP00000020340WH1 domain-containing protein. (244 aa)
ENSUAMP00000021241C2 domain-containing protein. (766 aa)
ENSUAMP00000021250Uncharacterized protein. (870 aa)
SIX4SIX homeobox 4. (783 aa)
TNNT1Troponin T1, slow skeletal type. (256 aa)
LRRC10BLeucine rich repeat containing 10B. (292 aa)
ACTN2Actinin alpha 2. (894 aa)
MEF2AMyocyte enhancer factor 2A. (466 aa)
LMOD3Leiomodin 3. (564 aa)
ENSUAMP00000023660Uncharacterized protein. (778 aa)
ACTG2Actin gamma 2, smooth muscle. (389 aa)
KLHL41Kelch like family member 41. (606 aa)
ENSUAMP00000024290Uncharacterized protein. (186 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
MYPNMyopalladin. (1320 aa)
WFIKKN1WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 1. (548 aa)
ENSUAMP00000025619ADF-H domain-containing protein; Belongs to the actin-binding proteins ADF family. (153 aa)
LMOD1Leiomodin 1. (583 aa)
ENSUAMP00000026324Uncharacterized protein. (168 aa)
ENSUAMP00000026326SH3 domain-containing protein. (99 aa)
TNNT3Troponin T3, fast skeletal type. (260 aa)
R3HDM2Uncharacterized protein. (1084 aa)
STAC3SH3 and cysteine rich domain 3. (407 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
LMOD2Leiomodin 2. (553 aa)
TMOD2Tropomodulin 2. (351 aa)
TMOD3Tropomodulin 3. (360 aa)
FLNCFilamin C. (2681 aa)
DYSFDysferlin. (2066 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
ENGEndoglin. (650 aa)
CAV3Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
ENSUAMP00000032138Uncharacterized protein. (111 aa)
HOMER1Homer scaffold protein 1. (191 aa)
ASB2Ankyrin repeat and SOCS box containing 2. (630 aa)
R3HDM1R3H domain containing 1. (830 aa)
BIN3Bridging integrator 3. (253 aa)
ENSUAMP00000033199RHD domain-containing protein. (458 aa)
CXADRUncharacterized protein. (350 aa)
MYOM2Myomesin 2. (1445 aa)
PRKAR1AProtein kinase cAMP-dependent type I regulatory subunit alpha. (381 aa)
ENSUAMP00000033749Uncharacterized protein. (344 aa)
ENSUAMP00000033750Uncharacterized protein. (66 aa)
FHL2Four and a half LIM domains 2. (279 aa)
NOTCH1Notch receptor 1. (2547 aa)
NEBNebulin. (7814 aa)
ENSUAMP00000034792Uncharacterized protein. (279 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
TMOD4Tropomodulin 4. (345 aa)
LDB3LIM domain binding 3. (705 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
PGM5Phosphoglucomutase 5; Belongs to the phosphohexose mutase family. (567 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
ENSUAMP00000037129Uncharacterized protein. (66 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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