39 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ASB2	Ankyrin repeat and SOCS box containing 2. (630 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	TBX5	T-box transcription factor 5. (517 aa)
	ENSUAMP00000005311	Uncharacterized protein. (1199 aa)
	CSRP3	Cysteine and glycine rich protein 3. (194 aa)
	ENSUAMP00000007554	Uncharacterized protein. (354 aa)
	ALPK3	Alpha kinase 3. (1619 aa)
	NRAP	Nebulin related anchoring protein. (1729 aa)
	MYLK3	Myosin light chain kinase 3. (791 aa)
	ENSUAMP00000011392	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (762 aa)
	TCAP	Titin-cap. (167 aa)
	ADPRH	ADP-ribosylarginine hydrolase. (362 aa)
	BVES	Blood vessel epicardial substance. (323 aa)
	NKX2-6	NK2 homeobox 6. (268 aa)
	ENSUAMP00000015680	Uncharacterized protein. (92 aa)
	MAML1	Mastermind like transcriptional coactivator 1. (933 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	LMNA	Lamin A/C; Belongs to the intermediate filament family. (671 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2523 aa)
	SRF	Serum response factor. (507 aa)
	LRRC10B	Leucine rich repeat containing 10B. (292 aa)
	ACTN2	Actinin alpha 2. (894 aa)
	MEF2A	Myocyte enhancer factor 2A. (466 aa)
	ATG5	Autophagy protein 5; Involved in autophagic vesicle formation. (275 aa)
	ENSUAMP00000026324	Uncharacterized protein. (168 aa)
	ENSUAMP00000026326	SH3 domain-containing protein. (99 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (151 aa)
	CXADR	Uncharacterized protein. (350 aa)
	FHL2	Four and a half LIM domains 2. (279 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
	NEB	Nebulin. (7814 aa)
	ENSUAMP00000034792	Uncharacterized protein. (279 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	ZMPSTE24	CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTN2	CAV3	ENSUAMP00000022729	ENSUAMP00000031548	Actinin alpha 2.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.410
ACTN2	CSRP3	ENSUAMP00000022729	ENSUAMP00000007368	Actinin alpha 2.	Cysteine and glycine rich protein 3.	0.716
ACTN2	ENSUAMP00000011392	ENSUAMP00000022729	ENSUAMP00000011392	Actinin alpha 2.	Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.474
ACTN2	ENSUAMP00000026324	ENSUAMP00000022729	ENSUAMP00000026324	Actinin alpha 2.	Uncharacterized protein.	0.491
ACTN2	ENSUAMP00000026326	ENSUAMP00000022729	ENSUAMP00000026326	Actinin alpha 2.	SH3 domain-containing protein.	0.491
ACTN2	MYLK3	ENSUAMP00000022729	ENSUAMP00000011171	Actinin alpha 2.	Myosin light chain kinase 3.	0.541
ACTN2	NEB	ENSUAMP00000022729	ENSUAMP00000034701	Actinin alpha 2.	Nebulin.	0.611
ACTN2	NRAP	ENSUAMP00000022729	ENSUAMP00000009097	Actinin alpha 2.	Nebulin related anchoring protein.	0.538
ACTN2	TBX5	ENSUAMP00000022729	ENSUAMP00000002282	Actinin alpha 2.	T-box transcription factor 5.	0.533
ACTN2	TCAP	ENSUAMP00000022729	ENSUAMP00000011522	Actinin alpha 2.	Titin-cap.	0.721
ATG5	MTOR	ENSUAMP00000024668	ENSUAMP00000019324	Autophagy protein 5; Involved in autophagic vesicle formation.	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family.	0.538
BMP10	BMPR1A	ENSUAMP00000015898	ENSUAMP00000036181	Bone morphogenetic protein 10.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.575
BMP10	TBX5	ENSUAMP00000015898	ENSUAMP00000002282	Bone morphogenetic protein 10.	T-box transcription factor 5.	0.468
BMPR1A	BMP10	ENSUAMP00000036181	ENSUAMP00000015898	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 10.	0.575
CAV3	ACTN2	ENSUAMP00000031548	ENSUAMP00000022729	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Actinin alpha 2.	0.410
CAV3	CSRP3	ENSUAMP00000031548	ENSUAMP00000007368	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cysteine and glycine rich protein 3.	0.623
CAV3	ENSUAMP00000015680	ENSUAMP00000031548	ENSUAMP00000015680	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.660
CSRP3	ACTN2	ENSUAMP00000007368	ENSUAMP00000022729	Cysteine and glycine rich protein 3.	Actinin alpha 2.	0.716
CSRP3	CAV3	ENSUAMP00000007368	ENSUAMP00000031548	Cysteine and glycine rich protein 3.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.623
CSRP3	NEB	ENSUAMP00000007368	ENSUAMP00000034701	Cysteine and glycine rich protein 3.	Nebulin.	0.417