STRINGSTRING
MYL2 MYL2 MYLK2 MYLK2 ENG ENG ENSUAMP00000028668 ENSUAMP00000028668 SMAD7 SMAD7 TBX20 TBX20 XIRP2 XIRP2 HAND1 HAND1 LRP2 LRP2 BMP2 BMP2 DLL4 DLL4 ZFPM2 ZFPM2 MYBPC3 MYBPC3 SMAD4 SMAD4 TGFBR1 TGFBR1 BMP10 BMP10 ENSUAMP00000012276 ENSUAMP00000012276 ENSUAMP00000010858 ENSUAMP00000010858 WNT2 WNT2 PTCD2 PTCD2 FOXH1 FOXH1 TNNC1 TNNC1 TNNI1 TNNI1 ENSUAMP00000004728 ENSUAMP00000004728 TCAP TCAP ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004638 ENSUAMP00000004638 NKX2-5 NKX2-5 PROX1 PROX1 NOG NOG ANKRD1 ANKRD1 PKP2 PKP2 ENSUAMP00000010867 ENSUAMP00000010867 BMPR1A BMPR1A ENSUAMP00000035960 ENSUAMP00000035960 MYL10 MYL10 NOTCH1 NOTCH1 MED1 MED1 CHD7 CHD7
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYL2Myosin light chain 2. (192 aa)
MYLK2Myosin light chain kinase 2. (615 aa)
ENGEndoglin. (650 aa)
ENSUAMP00000028668Uncharacterized protein. (138 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
TBX20T-box transcription factor 20. (448 aa)
XIRP2Xin actin binding repeat containing 2. (3766 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
LRP2LDL receptor related protein 2. (4684 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (716 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1193 aa)
MYBPC3Myosin binding protein C, cardiac. (1245 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
ENSUAMP00000012276B30.2/SPRY domain-containing protein. (334 aa)
ENSUAMP00000010858Myosin_tail_1 domain-containing protein. (890 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
PTCD2Pentatricopeptide repeat domain 2. (427 aa)
FOXH1Forkhead box H1. (370 aa)
TNNC1Troponin C1, slow skeletal and cardiac type. (158 aa)
TNNI1Troponin I1, slow skeletal type. (185 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
TCAPTitin-cap. (167 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004638Uncharacterized protein. (148 aa)
NKX2-5NK2 homeobox 5. (323 aa)
PROX1Prospero homeobox 1. (737 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
ANKRD1Ankyrin repeat domain 1. (319 aa)
PKP2Plakophilin 2. (829 aa)
ENSUAMP00000010867Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (207 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
ENSUAMP00000035960Uncharacterized protein. (707 aa)
MYL10Myosin light chain 10. (215 aa)
NOTCH1Notch receptor 1. (2547 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2987 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.