STRINGSTRING
ENSUAMP00000001392 ENSUAMP00000001392 WNT6 WNT6 LATS2 LATS2 LRP6 LRP6 FZD2 FZD2 WNT11 WNT11 WNT8B WNT8B SFRP1 SFRP1 ENSUAMP00000004725 ENSUAMP00000004725 ENSUAMP00000004728 ENSUAMP00000004728 FGF9 FGF9 DVL3 DVL3 TCF7 TCF7 WNT2B WNT2B CAV1 CAV1 WNT2 WNT2 SDC1 SDC1 ENSUAMP00000010104 ENSUAMP00000010104 FZD4 FZD4 SFRP4 SFRP4 FZD5 FZD5 RAPGEF1 RAPGEF1 GSK3B GSK3B FOXO3 FOXO3 FOXO3B FOXO3B ENSUAMP00000012266 ENSUAMP00000012266 WNT3A WNT3A WNT9A WNT9A SFRP5 SFRP5 EXT1 EXT1 CBY1 CBY1 LGR4 LGR4 WNT7B WNT7B DVL1 DVL1 SOSTDC1 SOSTDC1 CTNNB1 CTNNB1 PYGO2 PYGO2 PYGO1 PYGO1 WNT10A WNT10A CTDNEP1 CTDNEP1 DVL2 DVL2 FZD6 FZD6 AXIN1 AXIN1 FZD9 FZD9 BCL9 BCL9 GPC3 GPC3 WNT16 WNT16 FZD3 FZD3 ENSUAMP00000022336 ENSUAMP00000022336 ENSUAMP00000022339 ENSUAMP00000022339 STK4 STK4 SOST SOST WNT5A WNT5A DIXDC1 DIXDC1 FRZB FRZB WNT8A WNT8A LRP5 LRP5 ENSUAMP00000025477 ENSUAMP00000025477 TCF7L2 TCF7L2 WNT4 WNT4 SOX9 SOX9 ENSUAMP00000026963 ENSUAMP00000026963 FZD10 FZD10 GATA3 GATA3 ENSUAMP00000029322 ENSUAMP00000029322 EDN1 EDN1 JUP JUP FZD7 FZD7 ENSUAMP00000032923 ENSUAMP00000032923 CDH3 CDH3 RECK RECK RSPO3 RSPO3 WNT1 WNT1 WNT10B WNT10B SIAH2 SIAH2 WNT7A WNT7A ENSUAMP00000035777 ENSUAMP00000035777 WNT3 WNT3 WNT9B WNT9B HESX1 HESX1 RAB5A RAB5A FZD1 FZD1 TCF7L1 TCF7L1 SCYL2 SCYL2 BCL9L BCL9L
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSUAMP00000001392Uncharacterized protein; Belongs to the G-protein coupled receptor Fz/Smo family. (545 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (367 aa)
LATS2Non-specific serine/threonine protein kinase. (1084 aa)
LRP6LDL receptor related protein 6. (1431 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
WNT8BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (332 aa)
SFRP1Secreted frizzled related protein 1. (337 aa)
ENSUAMP00000004725G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (253 aa)
ENSUAMP00000004728G_PROTEIN_RECEP_F1_2 domain-containing protein. (155 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
TCF7Transcription factor 7. (443 aa)
WNT2BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (299 aa)
CAV1Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (178 aa)
WNT2Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (360 aa)
SDC1Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (301 aa)
ENSUAMP00000010104acidPPc domain-containing protein. (312 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
FZD5Frizzled class receptor 5; Belongs to the G-protein coupled receptor Fz/Smo family. (727 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1234 aa)
GSK3BGlycogen synthase kinase 3 beta. (335 aa)
FOXO3Forkhead box O3. (453 aa)
FOXO3BForkhead box O3B. (244 aa)
ENSUAMP00000012266CTNNB1_binding domain-containing protein. (162 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (356 aa)
WNT9AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
SFRP5Secreted frizzled related protein 5. (316 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
CBY1Chibby family member 1, beta catenin antagonist. (127 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (971 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
SOSTDC1Sclerostin domain containing 1. (206 aa)
CTNNB1Catenin beta 1. (781 aa)
PYGO2Pygopus family PHD finger 2. (369 aa)
PYGO1Pygopus family PHD finger 1. (398 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
CTDNEP1CTD nuclear envelope phosphatase 1. (244 aa)
DVL2Dishevelled segment polarity protein 2. (731 aa)
FZD6Frizzled class receptor 6; Belongs to the G-protein coupled receptor Fz/Smo family. (657 aa)
AXIN1Axin 1. (867 aa)
FZD9Frizzled class receptor 9; Belongs to the G-protein coupled receptor Fz/Smo family. (561 aa)
BCL9BCL9 transcription coactivator. (1426 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (496 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (362 aa)
FZD3Frizzled class receptor 3; Belongs to the G-protein coupled receptor Fz/Smo family. (666 aa)
ENSUAMP00000022336Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (163 aa)
ENSUAMP00000022339Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (107 aa)
STK4Serine/threonine kinase 4. (487 aa)
SOSTSclerostin. (213 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
DIXDC1DIX domain containing 1. (691 aa)
FRZBFrizzled related protein. (298 aa)
WNT8AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (344 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSUAMP00000025477Uncharacterized protein. (185 aa)
TCF7L2Transcription factor 7 like 2. (524 aa)
WNT4Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (343 aa)
SOX9SRY-box transcription factor 9. (484 aa)
ENSUAMP00000026963Protein kinase domain-containing protein. (93 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
GATA3GATA binding protein 3. (444 aa)
ENSUAMP00000029322Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (102 aa)
EDN1Endothelin 1. (202 aa)
JUPJunction plakoglobin. (744 aa)
FZD7Frizzled class receptor 7; Belongs to the G-protein coupled receptor Fz/Smo family. (574 aa)
ENSUAMP00000032923Phosphatase and tensin homolog; Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine- phosphorylated proteins. Also acts as a lipid phosphatase. Belongs to the PTEN phosphatase protein family. (387 aa)
CDH3Cadherin 3; Cadherins are calcium-dependent cell adhesion proteins. (856 aa)
RECKReversion inducing cysteine rich protein with kazal motifs. (971 aa)
RSPO3R-spondin 3. (275 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SIAH2E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (325 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (349 aa)
ENSUAMP00000035777HMG box domain-containing protein. (191 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (338 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (361 aa)
HESX1HESX homeobox 1. (185 aa)
RAB5ARAB5A, member RAS oncogene family. (229 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (534 aa)
TCF7L1Transcription factor 7 like 1. (597 aa)
SCYL2SCY1 like pseudokinase 2. (745 aa)
BCL9LBCL9 like. (1497 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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