STRINGSTRING
TTC9 TTC9 ENSUAMP00000000161 ENSUAMP00000000161 P3H1 P3H1 WASF2 WASF2 MSX1 MSX1 ENSUAMP00000000756 ENSUAMP00000000756 LTF LTF EPYC EPYC TP53 TP53 AXIN2 AXIN2 SCUBE2 SCUBE2 SBDS SBDS SP5 SP5 ENSUAMP00000002886 ENSUAMP00000002886 ENSUAMP00000003016 ENSUAMP00000003016 PLS3 PLS3 RARG RARG NSD2 NSD2 BNC2 BNC2 ENSUAMP00000004452 ENSUAMP00000004452 SERPINH1 SERPINH1 CTC1 CTC1 TMEM107 TMEM107 INSIG2 INSIG2 TNFSF11 TNFSF11 EXT2 EXT2 DDR2 DDR2 NPPC NPPC COL3A1 COL3A1 ENSUAMP00000007696 ENSUAMP00000007696 ENSUAMP00000008871 ENSUAMP00000008871 MMP13 MMP13 PITX2 PITX2 ATF2 ATF2 PTPN11 PTPN11 ENSUAMP00000010461 ENSUAMP00000010461 VKORC1 VKORC1 SFRP4 SFRP4 ABI1 ABI1 NPR2 NPR2 ENSUAMP00000012599 ENSUAMP00000012599 ENSUAMP00000012787 ENSUAMP00000012787 CHAD CHAD RARB RARB EXT1 EXT1 MEGF8 MEGF8 OSTN OSTN SNX10 SNX10 MPIG6B MPIG6B LRRC17 LRRC17 PAFAH1B1 PAFAH1B1 CCDC154 CCDC154 ENSUAMP00000016726 ENSUAMP00000016726 RAB23 RAB23 MEF2D MEF2D NEUROG1 NEUROG1 TIFAB TIFAB BGLAP BGLAP OGN OGN PIP4K2A PIP4K2A HOXA11 HOXA11 ECM1 ECM1 PAPPA2 PAPPA2 ACTN3 ACTN3 KIT KIT ENSUAMP00000018947 ENSUAMP00000018947 ENSUAMP00000018951 ENSUAMP00000018951 ENSUAMP00000019308 ENSUAMP00000019308 SRF SRF FREM1 FREM1 ENSUAMP00000020185 ENSUAMP00000020185 SMPD3 SMPD3 PHOSPHO1 PHOSPHO1 SLC38A10 SLC38A10 ENSUAMP00000020386 ENSUAMP00000020386 SEMA4D SEMA4D BMP2 BMP2 SMAD5 SMAD5 LEP LEP AMER1 AMER1 PEX7 PEX7 CITED2 CITED2 MATN1 MATN1 TMEM38B TMEM38B TFAP2A TFAP2A CCN4 CCN4 GP9 GP9 ENSUAMP00000024688 ENSUAMP00000024688 DHRS3 DHRS3 SULF2 SULF2 PAX1 PAX1 LRP5 LRP5 EVC EVC RANBP3L RANBP3L ENSUAMP00000026047 ENSUAMP00000026047 GLG1 GLG1 ATP6AP1 ATP6AP1 SOX9 SOX9 THBS3 THBS3 IMPAD1 IMPAD1 MAP2K6 MAP2K6 LTBP3 LTBP3 OSR2 OSR2 TULP3 TULP3 NAB2 NAB2 SULF1 SULF1 LEPR LEPR ENSUAMP00000027842 ENSUAMP00000027842 ENSUAMP00000027843 ENSUAMP00000027843 HOXB4 HOXB4 ZNF385A ZNF385A BMP4 BMP4 MMP14 MMP14 DLX5 DLX5 MEF2C MEF2C CER1 CER1 PPIB PPIB ALPL ALPL TGM2 TGM2 SRC SRC ENSUAMP00000030480 ENSUAMP00000030480 ANXA6 ANXA6 ASXL1 ASXL1 FGF18 FGF18 TMEM119 TMEM119 EP300 EP300 NOTUM NOTUM CDX1 CDX1 GLI3 GLI3 FGF4 FGF4 BMPR1B BMPR1B SH2B3 SH2B3 PDGFC PDGFC MED1 MED1 CYP26B1 CYP26B1 TRIM45 TRIM45 MIGA2 MIGA2 MBTPS2 MBTPS2 PTPN6 PTPN6 WNT1 WNT1 IFT80 IFT80 SH3PXD2B SH3PXD2B ZMPSTE24 ZMPSTE24 BGN BGN COMP COMP TRPV4 TRPV4 PHOSPHO2 PHOSPHO2 TRIP11 TRIP11 MMP16 MMP16 LRRK1 LRRK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TTC9Tetratricopeptide repeat domain 9. (244 aa)
ENSUAMP00000000161Uncharacterized protein. (78 aa)
P3H1Prolyl 3-hydroxylase 1. (736 aa)
WASF2WASP family member 2. (461 aa)
MSX1Msh homeobox 1. (303 aa)
ENSUAMP00000000756MH1 domain-containing protein. (170 aa)
LTFLactotransferrin; Belongs to the transferrin family. (706 aa)
EPYCEpiphycan. (319 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
AXIN2Axin 2. (843 aa)
SCUBE2Signal peptide, CUB domain and EGF like domain containing 2. (1071 aa)
SBDSSBDS ribosome maturation factor. (250 aa)
SP5Sp5 transcription factor. (399 aa)
ENSUAMP00000002886Uncharacterized protein. (479 aa)
ENSUAMP00000003016Uncharacterized protein. (461 aa)
PLS3Plastin 3. (630 aa)
RARGRetinoic acid receptor gamma. (458 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1344 aa)
BNC2Basonuclin 2. (711 aa)
ENSUAMP00000004452annotation not available (461 aa)
SERPINH1Serpin family H member 1; Belongs to the serpin family. (449 aa)
CTC1CST telomere replication complex component 1. (1227 aa)
TMEM107Transmembrane protein 107. (140 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (229 aa)
TNFSF11TNF superfamily member 11; Belongs to the tumor necrosis factor family. (242 aa)
EXT2Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (673 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (873 aa)
NPPCNatriuretic peptide C. (126 aa)
COL3A1Collagen type III alpha 1 chain. (997 aa)
ENSUAMP00000007696Fork-head domain-containing protein. (585 aa)
ENSUAMP00000008871Autophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (848 aa)
MMP13Matrix metallopeptidase 13. (484 aa)
PITX2Homeobox protein. (325 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3'); Belongs to the bZIP family. (505 aa)
PTPN11Protein tyrosine phosphatase non-receptor type 11. (552 aa)
ENSUAMP00000010461BHLH domain-containing protein. (178 aa)
VKORC1Vitamin K epoxide reductase complex subunit 1. (163 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
ABI1Abl interactor 1. (480 aa)
NPR2Guanylate cyclase. (1048 aa)
ENSUAMP00000012599Cystathionine beta-synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (573 aa)
ENSUAMP00000012787Fork-head domain-containing protein. (219 aa)
CHADChondroadherin. (313 aa)
RARBRetinoic acid receptor beta. (336 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (506 aa)
MEGF8Multiple EGF like domains 8. (2820 aa)
OSTNOsteocrin. (132 aa)
SNX10Sorting nexin 10. (201 aa)
MPIG6BMegakaryocyte and platelet inhibitory receptor G6b. (255 aa)
LRRC17Leucine rich repeat containing 17. (441 aa)
PAFAH1B1Platelet-activating factor acetylhydrolase IB subunit alpha; Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. Required during brain development for the proliferation of neuronal precursors and the migration of newly formed neurons from the ven [...] (410 aa)
CCDC154Coiled-coil domain containing 154. (682 aa)
ENSUAMP00000016726EXPERA domain-containing protein. (230 aa)
RAB23RAB23, member RAS oncogene family. (237 aa)
MEF2DMyocyte enhancer factor 2D. (515 aa)
NEUROG1Neurogenin 1. (251 aa)
TIFABTIFA inhibitor. (187 aa)
BGLAPOsteocalcin; Binds strongly to apatite and calcium. (93 aa)
OGNOsteoglycin. (297 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (246 aa)
HOXA11Homeobox A11. (313 aa)
ECM1Extracellular matrix protein 1. (422 aa)
PAPPA2Pappalysin 2. (1784 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (942 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (999 aa)
ENSUAMP00000018947Uncharacterized protein. (84 aa)
ENSUAMP00000018951Uncharacterized protein. (289 aa)
ENSUAMP00000019308Uncharacterized protein. (459 aa)
SRFSerum response factor. (507 aa)
FREM1FRAS1 related extracellular matrix 1. (1477 aa)
ENSUAMP00000020185Uncharacterized protein. (189 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
PHOSPHO1Phosphoethanolamine/phosphocholine phosphatase. (330 aa)
SLC38A10Solute carrier family 38 member 10. (1078 aa)
ENSUAMP00000020386Uncharacterized protein. (460 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (976 aa)
BMP2Bone morphogenetic protein 2. (395 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] (157 aa)
AMER1APC membrane recruitment protein 1. (1132 aa)
PEX7Peroxisomal biogenesis factor 7. (304 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
MATN1Matrilin 1. (497 aa)
TMEM38BTransmembrane protein 38B. (291 aa)
TFAP2ATranscription factor AP-2 alpha. (442 aa)
CCN4Cellular communication network factor 4. (361 aa)
GP9Glycoprotein IX platelet. (177 aa)
ENSUAMP00000024688Uncharacterized protein. (84 aa)
DHRS3Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
SULF2Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (870 aa)
PAX1Paired box 1. (432 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
EVCEvC ciliary complex subunit 1. (976 aa)
RANBP3LRAN binding protein 3 like. (394 aa)
ENSUAMP00000026047Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (612 aa)
GLG1Golgi glycoprotein 1. (1111 aa)
ATP6AP1ATPase H+ transporting accessory protein 1. (464 aa)
SOX9SRY-box transcription factor 9. (484 aa)
THBS3Thrombospondin 3. (1000 aa)
IMPAD1Inositol monophosphatase domain containing 1. (360 aa)
MAP2K6Mitogen-activated protein kinase kinase 6; Belongs to the protein kinase superfamily. (334 aa)
LTBP3Latent transforming growth factor beta binding protein 3. (1169 aa)
OSR2Odd-skipped related transciption factor 2. (312 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (444 aa)
NAB2NGFI-A binding protein 2. (492 aa)
SULF1Extracellular sulfatase; Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C- 6 position of glucosamine within specific subregions of intact heparin. Belongs to the sulfatase family. (940 aa)
LEPRLeptin receptor. (1166 aa)
ENSUAMP00000027842Uncharacterized protein. (99 aa)
ENSUAMP00000027843Uncharacterized protein. (119 aa)
HOXB4Homeobox B4. (240 aa)
ZNF385AZinc finger protein 385A. (386 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
MMP14Matrix metallopeptidase 14. (582 aa)
DLX5Distal-less homeobox 5. (289 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
CER1Cerberus 1, DAN family BMP antagonist. (279 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (224 aa)
ALPLAlkaline phosphatase. (524 aa)
TGM2Transglutaminase 2. (687 aa)
SRCTyrosine-protein kinase. (557 aa)
ENSUAMP00000030480HARE-HTH domain-containing protein. (88 aa)
ANXA6Annexin. (673 aa)
ASXL1ASXL transcriptional regulator 1. (1306 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (203 aa)
TMEM119Transmembrane protein 119. (288 aa)
EP300E1A binding protein p300. (2399 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (498 aa)
CDX1Caudal type homeobox 1. (265 aa)
GLI3GLI family zinc finger 3. (1413 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (197 aa)
BMPR1BSerine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (502 aa)
SH2B3SH2B adaptor protein 3. (374 aa)
PDGFCPlatelet derived growth factor C. (218 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1477 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (512 aa)
TRIM45Tripartite motif containing 45. (580 aa)
MIGA2Mitoguardin 2. (593 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (530 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
IFT80Intraflagellar transport 80. (768 aa)
SH3PXD2BSH3 and PX domains 2B. (887 aa)
ZMPSTE24CAAX prenyl protease; Proteolytically removes the C-terminal three residues of farnesylated proteins; Belongs to the peptidase M48A family. (475 aa)
BGNBiglycan; May be involved in collagen fiber assembly. Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (369 aa)
COMPCartilage oligomeric matrix protein. (756 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (861 aa)
PHOSPHO2Phosphatase, orphan 2. (241 aa)
TRIP11Thyroid hormone receptor interactor 11. (1978 aa)
MMP16Matrix metallopeptidase 16. (607 aa)
LRRK1Leucine rich repeat kinase 1. (2014 aa)
Your Current Organism:
Ursus americanus
NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus
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