(49 nodes) SMAD protein signal transduction network (Ursus americanus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ZMIZ1	Zinc finger MIZ-type containing 1. (1044 aa)
	ENSUAMP00000037566	TGF_BETA_2 domain-containing protein. (293 aa)
	VIM	Vimentin; Belongs to the intermediate filament family. (447 aa)
	ENSUAMP00000033771	Beta-hexosaminidase. (529 aa)
	BMP3	Bone morphogenetic protein 3; Belongs to the TGF-beta family. (475 aa)
	SMAD9	Mothers against decapentaplegic homolog. (469 aa)
	INHA	Inhibin alpha chain; Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition; Belongs to the TGF-beta family. (368 aa)
	HNF1A	HNF1 homeobox A. (631 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	SMAD2	Mothers against decapentaplegic homolog. (467 aa)
	SMAD6	Mothers against decapentaplegic homolog. (484 aa)
	SMAD3	Mothers against decapentaplegic homolog. (425 aa)
	INHBE	Inhibin subunit beta E. (351 aa)
	INHBC	Inhibin subunit beta C. (352 aa)
	SKI	SKI proto-oncogene. (704 aa)
	CITED1	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 1. (195 aa)
	ENSUAMP00000022406	Uncharacterized protein. (242 aa)
	SMAD5	Mothers against decapentaplegic homolog. (465 aa)
	NCEH1	Neutral cholesterol ester hydrolase 1. (402 aa)
	HNF4A	Hepatocyte nuclear factor 4 alpha. (474 aa)
	NUP93	Nuclear pore complex protein Nup93; Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance; Belongs to the nucleoporin interacting component (NIC) family. (819 aa)
	BMP2	Bone morphogenetic protein 2. (395 aa)
	ENSUAMP00000020920	Uncharacterized protein. (86 aa)
	TGFB2	Transforming growth factor beta; Belongs to the TGF-beta family. (439 aa)
	AFP	Alpha fetoprotein. (614 aa)
	SLC33A1	Solute carrier family 33 member 1. (550 aa)
	RBM14	RNA binding motif protein 14. (618 aa)
	GDF11	Growth differentiation factor 11. (409 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ENSUAMP00000016793	BZIP domain-containing protein. (179 aa)
	TGFB3	Transforming growth factor beta; Belongs to the TGF-beta family. (412 aa)
	BMP10	Bone morphogenetic protein 10. (424 aa)
	ATOH8	Atonal bHLH transcription factor 8. (322 aa)
	GDF3	Growth differentiation factor 3. (365 aa)
	ENSUAMP00000012044	TGF_BETA_2 domain-containing protein. (154 aa)
	NODAL	Nodal growth differentiation factor. (348 aa)
	GDF5	Growth differentiation factor 5. (499 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (334 aa)
	ENSUAMP00000008401	TGF_BETA_2 domain-containing protein. (367 aa)
	INHBA	Inhibin subunit beta A. (424 aa)
	ENSUAMP00000005012	Uncharacterized protein. (59 aa)
	ENSUAMP00000001661	TGF_BETA_2 domain-containing protein. (194 aa)
	HIPK2	Homeodomain interacting protein kinase 2. (1200 aa)
	ENSUAMP00000000756	MH1 domain-containing protein. (170 aa)
	GDF6	Growth differentiation factor 6. (289 aa)
	GDF10	Growth differentiation factor 10. (483 aa)
	GDF2	Growth differentiation factor 2. (429 aa)
	SUB1	SUB1 regulator of transcription. (127 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AFP	BMP4	ENSUAMP00000020424	ENSUAMP00000028868	Alpha fetoprotein.	Bone morphogenetic protein 4.	0.490
AFP	ENSUAMP00000008401	ENSUAMP00000020424	ENSUAMP00000008401	Alpha fetoprotein.	TGF_BETA_2 domain-containing protein.	0.425
AFP	GDF3	ENSUAMP00000020424	ENSUAMP00000014499	Alpha fetoprotein.	Growth differentiation factor 3.	0.425
AFP	HNF4A	ENSUAMP00000020424	ENSUAMP00000021749	Alpha fetoprotein.	Hepatocyte nuclear factor 4 alpha.	0.753
BMP10	BMP4	ENSUAMP00000015898	ENSUAMP00000028868	Bone morphogenetic protein 10.	Bone morphogenetic protein 4.	0.579
BMP10	ENSUAMP00000012044	ENSUAMP00000015898	ENSUAMP00000012044	Bone morphogenetic protein 10.	TGF_BETA_2 domain-containing protein.	0.623
BMP10	GDF2	ENSUAMP00000015898	ENSUAMP00000000160	Bone morphogenetic protein 10.	Growth differentiation factor 2.	0.861
BMP10	SMAD2	ENSUAMP00000015898	ENSUAMP00000026566	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.407
BMP10	SMAD3	ENSUAMP00000015898	ENSUAMP00000026563	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.604
BMP10	SMAD4	ENSUAMP00000015898	ENSUAMP00000018392	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.499
BMP10	SMAD5	ENSUAMP00000015898	ENSUAMP00000022170	Bone morphogenetic protein 10.	Mothers against decapentaplegic homolog.	0.535
BMP2	BMP4	ENSUAMP00000021596	ENSUAMP00000028868	Bone morphogenetic protein 2.	Bone morphogenetic protein 4.	0.943
BMP2	ENSUAMP00000000756	ENSUAMP00000021596	ENSUAMP00000000756	Bone morphogenetic protein 2.	MH1 domain-containing protein.	0.816
BMP2	ENSUAMP00000012044	ENSUAMP00000021596	ENSUAMP00000012044	Bone morphogenetic protein 2.	TGF_BETA_2 domain-containing protein.	0.730
BMP2	GDF5	ENSUAMP00000021596	ENSUAMP00000009595	Bone morphogenetic protein 2.	Growth differentiation factor 5.	0.520
BMP2	SMAD2	ENSUAMP00000021596	ENSUAMP00000026566	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.654
BMP2	SMAD3	ENSUAMP00000021596	ENSUAMP00000026563	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.617
BMP2	SMAD4	ENSUAMP00000021596	ENSUAMP00000018392	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.854
BMP2	SMAD5	ENSUAMP00000021596	ENSUAMP00000022170	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.800
BMP2	SMAD6	ENSUAMP00000021596	ENSUAMP00000026564	Bone morphogenetic protein 2.	Mothers against decapentaplegic homolog.	0.750