45 items (Ursus americanus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CCN1	Cellular communication network factor 1. (382 aa)
	CITED2	Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (278 aa)
	GJA5	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (358 aa)
	NRP2	Neuropilin; Belongs to the neuropilin family. (851 aa)
	ZFPM2	Zinc finger protein, FOG family member 2. (1193 aa)
	ENSUAMP00000018820	Uncharacterized protein. (802 aa)
	SMAD4	Mothers against decapentaplegic homolog. (552 aa)
	ENSUAMP00000017830	Uncharacterized protein. (157 aa)
	TGFBR1	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (501 aa)
	ENSUAMP00000015361	CUB domain-containing protein. (131 aa)
	APLNR	Apelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
	HES1	Hes family bHLH transcription factor 1. (259 aa)
	GATA4	GATA binding protein 4. (443 aa)
	ENSUAMP00000007313	Uncharacterized protein. (67 aa)
	MKS1	MKS transition zone complex subunit 1. (689 aa)
	PARVA	Parvin alpha. (286 aa)
	NSD2	Nuclear receptor binding SET domain protein 2. (1344 aa)
	NKX2-5	NK2 homeobox 5. (323 aa)
	DHRS3	Dehydrogenase/reductase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (302 aa)
	SEMA3C	Semaphorin 3C; Belongs to the semaphorin family. (750 aa)
	TBX20	T-box transcription factor 20. (448 aa)
	SMAD6	Mothers against decapentaplegic homolog. (484 aa)
	SMAD7	Mothers against decapentaplegic homolog. (426 aa)
	SMO	Smoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
	BMP4	Bone morphogenetic protein 4. (409 aa)
	SLIT3	Slit guidance ligand 3. (1441 aa)
	ENG	Endoglin. (650 aa)
	SAV1	Salvador family WW domain containing protein 1. (384 aa)
	NOTCH2	Notch receptor 2. (2374 aa)
	CHD7	Chromodomain helicase DNA binding protein 7. (2987 aa)
	NOTCH1	Notch receptor 1. (2547 aa)
	JAG1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1226 aa)
	BMPR1A	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
	BMPR2	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (857 aa)
	ENSUAMP00000003258	Uncharacterized protein. (246 aa)
	WNT11	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
	TBX5	T-box transcription factor 5. (517 aa)
	PROX1	Prospero homeobox 1. (737 aa)
	FZD2	Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (563 aa)
	NOG	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
	TBX2	T-box transcription factor 2. (697 aa)
	TP53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (381 aa)
	ENSUAMP00000000600	Uncharacterized protein. (130 aa)
	HAND1	Heart and neural crest derivatives expressed 1. (218 aa)
	LRP2	LDL receptor related protein 2. (4684 aa)

Your Current Organism:

Ursus americanus

NCBI taxonomy Id: 9643
Other names: American black bear, Euarctos americanus, U. americanus

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
APLNR	GJA5	ENSUAMP00000014445	ENSUAMP00000021558	Apelin receptor; Belongs to the G-protein coupled receptor 1 family.	Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.	0.539
BMP4	BMPR1A	ENSUAMP00000028868	ENSUAMP00000036181	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.997
BMP4	BMPR2	ENSUAMP00000028868	ENSUAMP00000036920	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.990
BMP4	ENSUAMP00000000600	ENSUAMP00000028868	ENSUAMP00000000600	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	ENSUAMP00000017830	ENSUAMP00000028868	ENSUAMP00000017830	Bone morphogenetic protein 4.	Uncharacterized protein.	0.428
BMP4	GATA4	ENSUAMP00000028868	ENSUAMP00000009143	Bone morphogenetic protein 4.	GATA binding protein 4.	0.679
BMP4	JAG1	ENSUAMP00000028868	ENSUAMP00000034607	Bone morphogenetic protein 4.	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	0.656
BMP4	NKX2-5	ENSUAMP00000028868	ENSUAMP00000003298	Bone morphogenetic protein 4.	NK2 homeobox 5.	0.452
BMP4	NOG	ENSUAMP00000028868	ENSUAMP00000001684	Bone morphogenetic protein 4.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.996
BMP4	NOTCH1	ENSUAMP00000028868	ENSUAMP00000034225	Bone morphogenetic protein 4.	Notch receptor 1.	0.426
BMP4	SMAD4	ENSUAMP00000028868	ENSUAMP00000018392	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.888
BMP4	SMAD6	ENSUAMP00000028868	ENSUAMP00000026564	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.741
BMP4	SMAD7	ENSUAMP00000028868	ENSUAMP00000027174	Bone morphogenetic protein 4.	Mothers against decapentaplegic homolog.	0.715
BMP4	TBX5	ENSUAMP00000028868	ENSUAMP00000002282	Bone morphogenetic protein 4.	T-box transcription factor 5.	0.540
BMP4	TGFBR1	ENSUAMP00000028868	ENSUAMP00000016865	Bone morphogenetic protein 4.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.807
BMP4	WNT11	ENSUAMP00000028868	ENSUAMP00000002348	Bone morphogenetic protein 4.	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family.	0.442
BMPR1A	BMP4	ENSUAMP00000036181	ENSUAMP00000028868	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Bone morphogenetic protein 4.	0.997
BMPR1A	BMPR2	ENSUAMP00000036181	ENSUAMP00000036920	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	0.977
BMPR1A	ENG	ENSUAMP00000036181	ENSUAMP00000030016	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Endoglin.	0.403
BMPR1A	NOG	ENSUAMP00000036181	ENSUAMP00000001684	Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.	Noggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.	0.700